Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
El Repositorio Digital de la Universidad Nacional de Córdoba (RDU), es un espacio donde se almacena, organiza, preserva, prov ee acceso libre y procura dar visibilidad a nivel nacional e internacional, a la producción científica, académica y cultural en formato digital , generada por los integrantes de la comunidad universitaria. RISK GENES IN HEAD AND NECK CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF LAST 5 YEARSBrunotto Cita del documento:Brunotto, M, Zarate, A.M, Bono, A, Barra, J.L, Berra, S. Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years. Oral Oncol. 2014;3(50): 178-188. Disponible en: https://rdu.unc.edu.ar/handle/11086/5502Este documento está disponible para su consulta y descarga en RDU (Repositorio Digital de la Universidad Nacional de Córdoba) . El mismo almacena, organiza, preserva, provee acceso libre y da visibilidad a nivel nacional e internacional a la producción científica, académica y cultural en formato digital, generada por los miembros de la Universidad Nacional de Córdoba. Para más información, visite el sitio https://rdu.unc.edu.ar/ Esta iniciativa está a cargo de la OCA (Oficina de Conocimiento Abierto), conjuntamente con la colaboración de la Prosecretaria de Informática de la Universidad Nacional de Córdoba y los Nodos OCA. Para más información, visite el sitio http://oca.unc.edu.ar/ It is known that the apoptotic and proliferation genes are involved in cancer development and these could be useful as a biomarker of this pathology. Systematic reviews and meta-analysis allow stronger and more generalized conclusions for identifying some models of risk markers. These models may help in screening, early diagnosis and/or therapy in the clinic. 2-5In recent decades, there has been increased interest in genetic predisposition studies in complex disease. This has led to the production of an enormous number of epidemiologic papers about the relationship between genetic polymorphism and disease. However, the magnitude of association between specific polymorphism and disease is still not established. The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. METHODS Search strategy and selection criteriaThis study was made according to the PRISMA reporting items for systematic reviews and metaanalysis guidelines. We conducted a systematic review and meta-analysis of case-control studies from the MEDLINE, Scopus, Cochrane, and CancerLit databases between January 2007 and January 2013. Language is not restricted. The search strategy included the following keywords 3 (variably combined): "oral cancer", "oral cancer polymorphism", "oncogene", "tumor suppressor gene", "squamous cell carcinoma", "head and neck cancer". Data extractionData was collected of adult patients of both genders, with diagnosis of head and neck carcinoma according to the criteria of ICD-10C00-C14 WHO or another specific source, in whom genetic polymorphisms ...
El Repositorio Digital de la Universidad Nacional de Córdoba (RDU), es un espacio donde se almacena, organiza, preserva, prov ee acceso libre y procura dar visibilidad a nivel nacional e internacional, a la producción científica, académica y cultural en formato digital , generada por los integrantes de la comunidad universitaria. RISK GENES IN HEAD AND NECK CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS OF LAST 5 YEARSBrunotto Cita del documento:Brunotto, M, Zarate, A.M, Bono, A, Barra, J.L, Berra, S. Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years. Oral Oncol. 2014;3(50): 178-188. Disponible en: https://rdu.unc.edu.ar/handle/11086/5502Este documento está disponible para su consulta y descarga en RDU (Repositorio Digital de la Universidad Nacional de Córdoba) . El mismo almacena, organiza, preserva, provee acceso libre y da visibilidad a nivel nacional e internacional a la producción científica, académica y cultural en formato digital, generada por los miembros de la Universidad Nacional de Córdoba. Para más información, visite el sitio https://rdu.unc.edu.ar/ Esta iniciativa está a cargo de la OCA (Oficina de Conocimiento Abierto), conjuntamente con la colaboración de la Prosecretaria de Informática de la Universidad Nacional de Córdoba y los Nodos OCA. Para más información, visite el sitio http://oca.unc.edu.ar/ It is known that the apoptotic and proliferation genes are involved in cancer development and these could be useful as a biomarker of this pathology. Systematic reviews and meta-analysis allow stronger and more generalized conclusions for identifying some models of risk markers. These models may help in screening, early diagnosis and/or therapy in the clinic. 2-5In recent decades, there has been increased interest in genetic predisposition studies in complex disease. This has led to the production of an enormous number of epidemiologic papers about the relationship between genetic polymorphism and disease. However, the magnitude of association between specific polymorphism and disease is still not established. The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates. METHODS Search strategy and selection criteriaThis study was made according to the PRISMA reporting items for systematic reviews and metaanalysis guidelines. We conducted a systematic review and meta-analysis of case-control studies from the MEDLINE, Scopus, Cochrane, and CancerLit databases between January 2007 and January 2013. Language is not restricted. The search strategy included the following keywords 3 (variably combined): "oral cancer", "oral cancer polymorphism", "oncogene", "tumor suppressor gene", "squamous cell carcinoma", "head and neck cancer". Data extractionData was collected of adult patients of both genders, with diagnosis of head and neck carcinoma according to the criteria of ICD-10C00-C14 WHO or another specific source, in whom genetic polymorphisms ...
Optineurin (Optn) is a 577 aa protein encoded by the Optn gene. Mutations of Optn are associated with normal tension glaucoma and amyotrophic lateral sclerosis, and its gene has also been linked to the development of Paget’s disease of bone and Crohn’s disease. Optn is involved in diverse cellular functions, including NF-κB regulation, membrane trafficking, exocytosis, vesicle transport, reorganization of actin and microtubules, cell cycle control, and autophagy. Besides its role in xenophagy and autophagy of aggregates, Optn has been identified as a primary autophagy receptor, among the five adaptors that translocate to mitochondria during mitophagy. Mitophagy is a selective macroautophagy process during which irreparable mitochondria are degraded, preventing accumulation of defective mitochondria and limiting the release of reactive oxygen species and proapoptotic factors. Mitochondrial quality control via mitophagy is central to the health of cells. One of the important surveillance pathways of mitochondrial health is the recently defined signal transduction pathway involving the mitochondrial PTEN-induced putative kinase 1 (PINK1) protein and the cytosolic RING-between-RING ubiquitin ligase Parkin. Both of these proteins, when mutated, have been identified in certain forms of Parkinson’s disease. By targeting ubiquitinated mitochondria to autophagosomes through its association with autophagy related proteins, Optn is responsible for a critical step in mitophagy. This review reports recent discoveries on the role of Optn in mitophagy and provides insight into its link with neurodegenerative diseases. We will also discuss the involvement of Optn in other pathologies in which mitophagy dysfunctions are involved including cancer.
In recent years, the study of single nucleotide polymorphisms (SNPs) has gained increasing importance in biomedical research, as they can either be at the molecular origin of a determined disorder or directly affect the efficiency of a given treatment. In this regard, sequence variations in genes involved in pro-survival cellular pathways are commonly associated with pathologies, as the alteration of these routes compromises cellular homeostasis. This is the case of autophagy, an evolutionarily conserved pathway that counteracts extracellular and intracellular stressors by mediating the turnover of cytosolic components through lysosomal degradation. Accordingly, autophagy dysregulation has been extensively described in a wide range of human pathologies, including cancer, neurodegeneration, or inflammatory alterations. Thus, it is not surprising that pathogenic gene variants in genes encoding crucial effectors of the autophagosome/lysosome axis are increasingly being identified. In this review, we present a comprehensive list of clinically relevant SNPs in autophagy-related genes, highlighting the scope and relevance of autophagy alterations in human disease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.