Análise discriminante dos pacientes portadores de glaucoma primário de ângulo aberto através do exame de Doppler colorido e do campo visual

Ramos, Maria Helena Mandello Carvalhães; Bergès, O.; Prata, João Antônio; Allemann, Norma

doi:10.1590/s0004-27492011000500011

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Many authors have reported that decreased choroidal flow can result in photoreceptor dysfunction, death, 6 glaucoma, 33 and increased severity of AMD. [7][8][9][10][11][12] However, some authors have speculated about a relationship between abnormal choroidal circulation that leads to increased CT and diseases such as in Vogt-Koyanagi-Harada, 13 central serous chorioretinopathy, 2 and others.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Choroidal Thickness and Ciliary Artery Blood Flow Velocity in Normal Subjects

Novais¹,

Badaró²,

Allemann³

et al. 2015

Ophthalmic Surg Lasers Imaging Retina

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Section: Discussionmentioning

confidence: 99%

Correlation Between Choroidal Thickness and Ciliary Artery Blood Flow Velocity in Normal Subjects

Novais¹,

Badaró²,

Allemann³

et al. 2015

Ophthalmic Surg Lasers Imaging Retina

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Neste fascículo do ABO

Chamon¹

2011

Arq. Bras. Oftalmol.

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This issue of ABO brings interesting articles in epidemiology, basic research, new technologies and randomized clinical trials.Kara-Júnior and his colleagues (1) presented the results of a questionnaire administered to more than 600 patients treated in a campaign to perform cataract surgery in São Paulo. The study showed a sad reality for patients excluded from the comprehensive eye care. Almost half of all patients interviewed were unable to gain access to cataract surgery before the campaign, because they have abandoned the free public service as a result of the long waiting lists or for failing to schedule their surgeries (19%), or did not have the resources to afford the costs associated with surgeries performed by health insurance or private care (29%). The costs reported by patients who had not sought public service ranged from R$ 1,000 to over R$ 4,000.00. Authors rightly emphasized in their conclusions "the need to continue to carry out community campaigns to meet people who would not have access to surgery by conventional means." I also believe it is important to consider that, despite the campaigns being indispensable at the present time the Brazilian public health, we must keep in mind that, ideally, access to health care should be possible for the whole population without the need to create specific campaigns.Patients with anophthalmic cavities were evaluated in two articles (2,3) . Narikawa and colleagues (2) retrospectively analyzed the epidemiological profile of 107 patients with anophthalmic cavity in a reference service in the state of São Paulo, detecting trauma as the most frequent etiology, especially in men. In another study conducted in the Federal District, Goulart and colleagues (3) assessed the psychosocial aspects involved in the rehabilitation of patients with anophthalmic cavity. In their study, which evaluated 44.4% of patients with anophthalmic cavity since 2004, the trauma was also nominated as the most frequent cause. In this sample, one third of patients said that the eye loss negatively influenced their daily routine.Several epidemiological, clinical and basic research articles focused on retinal aspects. In another epidemiological study, evaluating patients with sickle cell disease, Freitas and colleagues (4) demonstrated that routine eye examination may, in specific cases, establish clinical suspicion of systemic diseases. Gil and colleagues (5) conducted a randomized double-blind clinical trial to compare, through morphological and functional assessment, the treatment of diffuse diabetic macular edema with intravitreal triamcinolone and with laser phototherapy. Twenty-one eyes of 14 patients were randomly assigned to each group. Although intravitreal injection have led to the decrease in retinal thickness measured by OCT, the study showed no functional differences between the initial examination after three months of treatment in either group. In a study of basic research, evaluating a promising anti-inflammatory drug for intravitreal use, Rassi et al. (6) demonstrated that...

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Vascularization of choroidal melanomas as a prognostic factor: Comparative analysis between color Doppler and histopathological aspects of tumors

Costa,

Allemann,

Nehemy

et al. 2024

The Pan-American Journal of Ophthalmology

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Objectives: The objective of the study was to correlate color Doppler with the vascularization of choroidal melanoma (CM) observed in histopathological sections and also to analyze the vascular histopathological prognostic factors of these tumors. Patients, Materials, and Methods: This was an experimental, cross-sectional, and analytical study carried out at Escola Paulista de Medicina - UNIFESP (São Paulo) and at the Ocular Pathology and Translational Research Laboratory of McGill University (Montreal/Canada). Twenty-five enucleated eyes of patients with CM were studied, 10 patients studied at UNIFESP and 15 patients studied at McGill University. The first 10 patients (Brazil), before enucleation, were submitted to color Doppler, all performed at UNIFESP. The resistance index (RI) and maximum systolic velocity of each tumor were calculated. The inclusion criteria of this study were as follows: CMs >8 mm in thickness, enucleation as primary treatment, histopathological blocks sufficient for hematoxylin–eosin staining, periodic acid–Schiff, and CD34 immunohistochemistry. Exclusion criteria included tumors smaller than 8 mm and/or previous treatments such as laser or brachytherapy. Regarding the histopathology of each CM, cell-type classification, vessel diameter measurements, count of the number of mitoses, and vascular clefts were carried out. The latter are considered vessels because they are lined by endothelium (CD34 positive) and surrounded by melanoma cells. Results: There was a statistical correlation between RI and cell type (P < 0.05). Tumors with a better prognosis (spindle cell) showed higher RI compared to epithelioid tumors, with a worse prognosis. The number of mitoses and vascular clefts correlated with the cell type, with a statistically significant difference (P < 0.001). Tumors of worse prognosis (epithelioid) showed an increase in the number of mitoses and in the number of vascular clefts. There was no difference between vessel diameter and cell type. Conclusions: The number of vascular clefts has a positive prognostic correlation with the malignancy of CM. Doppler RI showed a positive prognostic correlation with CM malignancy. For the first time, the usefulness of vascular clefts as prognostic factors was proven, and a new classification of the vascular network in CMs was proposed.

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Análise discriminante dos pacientes portadores de glaucoma primário de ângulo aberto através do exame de Doppler colorido e do campo visual

Cited by 3 publications

References 21 publications

Correlation Between Choroidal Thickness and Ciliary Artery Blood Flow Velocity in Normal Subjects

Correlation Between Choroidal Thickness and Ciliary Artery Blood Flow Velocity in Normal Subjects

Neste fascículo do ABO

Vascularization of choroidal melanomas as a prognostic factor: Comparative analysis between color Doppler and histopathological aspects of tumors

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