Correlation Between Choroidal Thickness and Ciliary Artery Blood Flow Velocity in Normal Subjects

Novais, Eduardo Amorim; Badaró, Emmerson; Allemann, Norma; Morales, Maira Saad de Ávila; Rodrigues, Eduardo Büchele; Lima, Rodrigo de Souza; Regatieri, Caio V.; Belfort, Rubens

doi:10.3928/23258160-20151008-04

Cited by 23 publications

(19 citation statements)

References 34 publications

(23 reference statements)

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“…37,38 One consequence of our findings is that uncorrected presbyopia, which results in hyperopic retinal defocus at near, would be expected to cause choroidal thinning during sustained near tasks or while spending time in a near environment. Because choroidal thinning has been associated with reduced choroidal blood flow in healthy subjects, 18 our findings suggest that adults with uncorrected presbyopia who spend prolonged periods engaged in near work may experience reduced choroidal blood flow.…”

Section: Discussionmentioning

confidence: 68%

“…The proposed physiological mechanisms by which the choroid might dynamically increase or decrease in thickness include contraction and relaxation of nonvascular smooth muscle, 13 fluid redistribution as a result of osmotic changes, 16 and changes in choroidal blood flow. 17 Choroidal thickness and choroidal blood flow are correlated in animals 17 and healthy humans, 18,19 with choroidal thinning associated with reduced blood flow. Moreover, the choroid is typically thinner than normal, with reduced choroidal blood flow in patients with AMD [20][21][22][23] and those with diabetic retinopathy (DR).…”

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confidence: 99%

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Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia

Chiang

Chen

Phillips

2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate changes in subfoveal choroidal thickness (SFCT) induced by retinal defocus in presbyopic adults. METHODS. Thirty-seven healthy presbyopic subjects (age 57.74 6 4.06 years) with low refractive errors (þ0.08 6 1.09 Diopters [D]) viewed a distant target (video movie at 6 m) for 60 minutes on two occasions while SFCT was monitored with optical coherence tomography every 20 minutes. On each occasion, both eyes were optimally corrected for distance: one eye acted as control, while the other (experimental) eye viewed through an additional ophthalmic lens: a þ2.00 D lens imposing myopic defocus on one occasion and a À2.00 D lens imposing hyperopic defocus on the other occasion. RESULTS. Baseline SFCT was not different between experimental and control eyes (226 6 72 lm vs. 232 6 75 lm; P ¼ 0.28). Myopic defocus caused a significant (P < 0.001) increase in SFCT in the defocused eye by 20 minutes (and þ10 6 5-lm increase at 60 minutes: P < 0.001), while hyperopic defocus caused a significant decrease in SFCT by 20 minutes (and À10 6 5-lm decrease at 60 minutes: P < 0.001) with no change in control eyes. CONCLUSIONS. In presbyopic subjects, imposed myopic retinal defocus caused thickening of SFCT, while hyperopic defocus caused thinning of SFCT. This implies that uncorrected presbyopia, which is associated with hyperopic retinal defocus for near objects and which is highly prevalent in the developing world, would likely be associated with choroidal thinning and possibly reduced choroidal blood flow with prolonged periods in a near visual environment.

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Section: Discussionmentioning

confidence: 68%

mentioning

confidence: 99%

Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia

Chiang

Chen

Phillips

2018

Invest. Ophthalmol. Vis. Sci.

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“…CTh can be easily measured using inbuilt calipers on OCT imaging software, making it accessible in research and clinical settings. While the true correlation between CTh and in vivo choroidal function, such as choroidal blood flow, remains uncertain [5], CTh is the closest objective marker of choroidal health available with present imaging techniques, making it a topic of great interest in outer retinal health.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness in patients with coronary artery disease

et al. 2017

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PurposeTo evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.DesignCross-sectional.MethodsSetting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure. Twenty-eight age-matched controls had no self-reported history of CAD or diabetes. Patients with high myopia, dense cataracts, and retinal disease were excluded. Observation procedures: Enhanced depth imaging optical coherence tomography and questionnaire regarding medical and ocular history. Main outcome measures: Subfoveal CTh and CTh 2000 μm superior, inferior, nasal, and temporal to the fovea in the left eye, measured by 2 readers.ResultsCTh was significantly lower in patients with CAD compared to controls at the subfoveal location (252 vs. 303 μm, P = 0.002) and at all 4 cardinal macular locations. The mean difference in CTh between the 2 groups ranged from 46 to 75 μm and was greatest in the inferior location. Within the CAD group, CTh was significantly lower temporally (P = 0.007) and nasally (P<0.001) than subfoveally, consistent with the pattern observed in controls. On multivariate analysis, CAD was negatively associated with subfoveal CTh (P = 0.006) after controlling for diabetes, hypertension, and hypercholesterolemia.Conclusions and relevancePatients with CAD have a thinner macular choroid than controls, with preservation of the normal spatial CTh pattern. Decreased CTh might predispose patients with CAD to high-risk phenotypes of age-related macular degeneration such as reticular pseudodrusen and could serve as a potential biomarker of disease in CAD.

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“…The proposed physiological mechanisms of dynamic increase or decrease of choroidal thickness include contraction and relaxation of nonvascular smooth muscle, 24 uid redistribution caused by osmotic changes, 25 and changes of choroidal blood ow. 26,27 It is known that surgical trauma can lead to the release of prostaglandins in the aqueous humor, thus causing damage to the blood/aqueous barrier. Our study found that CTs became signi cantly thicker 2 hours after surgery, especially in the fovea.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of changes in choroidal thickness after implantable collamer lens surgery in high myopia patients with Graves’ Ophthalmopathy (inactive phase)

Liu

Jia

et al. 2020

Preprint

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Background To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves’ ophthalmopathy (GO) by observing the changes of choroidal thickness (CT). Methods Eight patients (16 eyes) with high myopia accompanied with inactive GO were selected as the experimental group (group A) and 18 high myopic patients (36 eyes) without GO were selected as a control group (group B). The outcomes of uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BCVA), safety index, efficacy index, intraocular pressure (IOP), vault, corneal endothelial count, and choroidal thickness (CT) were observed. The values of CT were measured using swept-source optical coherence tomography (SS-OCT) scans. Results The UCVA and BCVA in all operated eyes were better than that before surgery. The postoperative safety index and efficacy index were 1.23 and 1.19 in the group A, respectively, and 1.26 and 1.21 in the group B, respectively. In both groups, foveal CT increased significantly in high myopic patients at 2 hours and at 3 months after surgery, compared to preoperative values. The same tendencies were observed in the inner nasal and outer nasal regions. Compared with patients without GO, the increase of CT was more obvious in GO patients, 2 hours postoperatively (P = 0.006) and 3 months postoperatively (P = 0.011). Conclusions The ICL implantation is safe and effective in high myopic patients with inactive GO. Subfoveal and nasal CT may be useful parameters for monitoring the activity of GO patients.

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Correlation Between Choroidal Thickness and Ciliary Artery Blood Flow Velocity in Normal Subjects

Cited by 23 publications

References 34 publications

Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia

Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia

Choroidal thickness in patients with coronary artery disease

Evaluation of changes in choroidal thickness after implantable collamer lens surgery in high myopia patients with Graves’ Ophthalmopathy (inactive phase)

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