Analgesics for pain after traumatic or orthopaedic surgery: what is the evidence-a systematic review

Montané, Eva; Vallano, Antonio; Aguilera, Cristina; Vidal, Xavier; Laporte, Joan‐Ramon

doi:10.1007/s00228-006-0185-0

Cited by 14 publications

(5 citation statements)

References 57 publications

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“…The quality of the evidence provided by orthopaedic journals about major orthopaedic surgery has been assessed, [2,3] as well as the quality of the RCTs assessing analgesic interventions [4]. We have assessed characteristics of patients included in RCTs on analgesics drugs for pain after TOS, as well as analgesic drugs, outcomes and observation periods in a previous study [5]. Nevertheless, quality in reporting RCTs of analgesics for postoperative pain after TOS has not been systematically assessed.…”

Section: Introductionmentioning

confidence: 99%

Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review

et al. 2010

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BackgroundSeveral randomised clinical trials (RCTs) of analgesics in postoperative pain after traumatic or orthopaedic surgery (TOS) have been published, but no studies have assessed the quality of these reports. We aimed to examine the quality of reporting RCTs on analgesics for postoperative pain after TOS.MethodsReports of RCTs assessing analgesics in postoperative pain after TOS were systematically searched from electronic databases. The quality of reports was assessed using the CONSORT checklist (scoring range from 0 to 22). The quality was considered poor when scoring was 12 or lesser. The publication year and the impact factor of journals were recorded.ResultsA total of 92 reports of RCTs were identified and 69 (75%) scored 12 or lesser in CONSORT checklist (range 5-17). The mean (SD) CONSORT score of all reports was 10.6 (2.7). Missing CONSORT items included primary and secondary outcome measures (11%), the specific objectives and hypothesis definition (12%), the sample size calculation (12%), the dates defining the periods of recruitment (12%), the discussion of external validity of findings (14%), the allocation sequence generation (24%), and the interpretation of potential bias or imprecision of results (25%). There was a little improvement in CONSORT scores over time (r = 0.62; p < 0.001) and with impact factor of journals (r = 0.30; p < 0.001).ConclusionQuality of reporting RCTs on analgesics after TOS is poor. Reporting of those RCTs should be improved according to methodological standard checklists in the next years.

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Section: Introductionmentioning

confidence: 99%

Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review

et al. 2010

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“…Although long term data are very limited, single doses of dezocine are well tolerated, with mild and transient sedation and gastrointestinal upset the principal adverse effects[22]. In single analgesic doses, dezocine is a slightly more potent respiratory depressant than morphine[23]. Clinically, important haemodynamic changes have not been observed with usual analgesic doses of dezocine.…”

Section: Discussionmentioning

confidence: 99%

Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy

Zhu

Jing

Yuan

2011

Journal of Biomedical Research

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Postoperative pain is the most common complaint after laparoscopic cholecystectomy. This study was carried out to evaluate whether preoperative administration of intramuscular dezocine can provide postoperative analgesia and reduce postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy. Patients (ASA I or II) scheduled for laparoscopic cholecystectomy were randomly assigned into intramuscular dezocine group (group 1) or intramuscular normal saline group (group 2). Dezocine and equal volume normal saline were administered intramuscularly 10 min before the induction of anesthesia. After operation, the severity of postoperative pain, postoperative fentanyl requirement, incidence and severity of side-effects were assessed. Postoperative pain and postoperative patient-controlled fentanyl consumption were reduced significantly in group 1 compared with group 2. The incidence and severity of side effects were similar between the two groups. Preoperative single-dose administration of intramuscular dezocine 0.1 mg/kg was effective in reducing postoperative pain and postoperative patient-controlled fentanyl requirement in patients undergoing laparoscopic cholecystectomy.

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“…Further studies should be conducted to investigate the 24 h morphine use if metamizole is given in repeated doses to patients undergoing lumbar disc surgery. According to Montané's (17) review article on postoperative pain therapy after traumatic orthopedic surgery (TOS), evidence regarding pain therapy after TOS was insufficient to identify the best method. It was mentioned that single-dose regimens of drugs were mostly studied, as in our study.…”

Section: Discussionmentioning

confidence: 99%

The addition of metamizole to morphine and paracetamol improves early postoperative analgesia and patient satisfaction after lumbar disc surgery

Uzun¹,

Aycan²,

Erden³

et al. 2010

Turkish Neurosurgery

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Analgesics for pain after traumatic or orthopaedic surgery: what is the evidence-a systematic review

Cited by 14 publications

References 57 publications

Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review

Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review

Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy

The addition of metamizole to morphine and paracetamol improves early postoperative analgesia and patient satisfaction after lumbar disc surgery

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