Analgesic Use and the Risk of Hearing Loss in Men

Curhan, Sharon G.; Eavey, Roland D.; Shargorodsky, Josef; Curhan, Gary C.

doi:10.1016/j.amjmed.2009.08.006

Cited by 76 publications

(65 citation statements)

References 54 publications

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“…In a previous study in men, researchers demonstrated that a longer duration of acetaminophen use was associated with a higher risk of hearing loss (53). Our data in women are consistent with these findings.…”

Section: Discussionsupporting

confidence: 92%

“…In NHS II, we found that regular use of NSAIDs was associated with a higher risk of hearing loss, and more frequent use tended to be associated with a higher risk (14). In a prospective study in men, Curhan et al (53) found a higher risk of hearing loss associated with a longer duration of NSAID use. Previous data have shown that the average use of NSAIDs within the NHS I cohort is, on average, much less than 3.2 g/day, the recommended maximum daily dose (51).…”

Section: Discussionmentioning

confidence: 68%

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Duration of Analgesic Use and Risk of Hearing Loss in Women

Lin¹,

Curhan²,

Wang³

et al. 2016

Am. J. Epidemiol.

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Aspirin, nonsteroidal antiinflammatory drugs (NSAID), and acetaminophen are commonly used. Frequent use of analgesics has been associated with a higher risk of hearing loss. However, the association between duration of analgesic use and the risk of hearing loss is unclear. We investigated the relationship between duration of analgesic use and self-reported hearing loss among 55,850 women in the Nurses' Health Study. Cox proportional hazards regression was used to adjust for potential confounders. During 873,376 personyears of follow-up (1990-2012), longer durations of NSAID use (for >6 years of use compared with <1 year, multivariable-adjusted relative risk = 1.10, 95% confidence interval: 1.06, 1.15; P for trend < 0.001) and acetaminophen use (for >6 years of use compared with <1 year, multivariable-adjusted relative risk = 1.09, 95% confidence interval: 1.04, 1.14; P for trend < 0.001) were associated with higher risks of hearing loss. Duration of aspirin use was not associated with hearing loss (for >6 years of use compared with <1 year, multivariableadjusted relative risk = 1.01, 95% confidence interval: 0.97, 1.05; P for trend = 0.35). In this cohort of women, longer durations of NSAID and acetaminophen use were associated with slightly higher risks of hearing loss, but duration of aspirin use was not. Considering the high prevalence of analgesic use, this may be an important modifiable contributor to hearing loss. acetaminophen; aspirin; hearing loss; nonsteroidal antiinflammatory drug Abbreviations: CI, confidence interval; NHS, Nurses' Health Study; NSAID, nonsteroidal antiinflammatory drug; RR, relative risk.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 68%

Duration of Analgesic Use and Risk of Hearing Loss in Women

Lin¹,

Curhan²,

Wang³

et al. 2016

Am. J. Epidemiol.

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“…Moreover, prospective associations between the outcome measure in this study and several risk factors have recently been demonstrated 13,29 . The participants in this cohort are not representative of the adult population in the U.S., but the follow-up rates are high and the information provided is reliable.…”

Section: Discussionmentioning

confidence: 62%

A Prospective Study of Cardiovascular Risk Factors and Incident Hearing Loss in Men

et al. 2010

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Objective-Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people. Cardiovascular risk factors have been associated with hearing loss risk in crosssectional studies, but prospective data are currently lacking.Methods-We prospectively evaluated the association between diagnosis of hypertension, diabetes mellitus, hypercholesterolemia, smoking and body mass index (BMI) and incidence of hearing loss. Participants were 26,917 men in the Health Professionals Follow-up Study, aged 40-74 years at baseline in 1986. Study participants completed questionnaires about lifestyle and medical history every two years.Information on self-reported professionally diagnosed hearing loss and year of diagnosis was obtained from the 2004 questionnaire, and cases were defined as hearing loss diagnosed between 1986 and 2004. Multivariable-adjusted hazard ratios (HRs) were calculated using Cox proportional hazards regression models.Results-3,488 cases of hearing loss were identified. History of hypertension (HR 0.96, 95% CI 0.88-1.03), diabetes mellitus (HR 0.92, 95% CI 0.78-1.08), or obesity (HR 1.02, 95% CI 0.90-1.15 for BMI≥30 compared to normal range of 19-24.9) was not significantly associated with hearing loss risk, while hypercholesterolemia (HR 1.10, 95% CI 1.02-1.18) and past smoking history (HR 1.09, 95% CI 1.01-1.17) were associated with a significantly increased risk of hearing loss after multivariate adjustment.Conclusion-A history of hypertension, diabetes mellitus, or obesity is not associated with increased risk of hearing loss, while a history of past smoking or hypercholesterolemia has a small but statistically significant association with increased risk of hearing loss in adult males.

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“…Although this communication did not analyze the risk factors directly linked with presbycusis, it is worthy to note that some of the patients had positive family history, and history of adequate contact with some of the risk factors especially use of ototoxic drugs. Some of these drugs are across the counter analgesics such as paracetamol, and non-steroidal anti-inflammatory drugs (NSAIDs) like acetylsalicylate which had been noted to increase the risk of hearing loss in men especially those younger than sixty years of age 13 . Studies had also noted that the presence of other chronic medical conditions tended to worsen presbycusis 14 .…”

Section: Discussionmentioning

confidence: 99%

Clinical and audiometric features of presbycusis in Nigerians

Sogebi¹,

Olusoga-Peters²,

Oluwapelumi³

2014

Afr H. Sci.

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Background: Presbycusis is the most common sensory impairment associated with ageing and it presents with variability of symptoms. Physicians need to recognize early clinical and audiometric signs of presbycusis in order to render adequate and quality care to patients and reduce associated morbidities. Objective: To characterize the clinical modes of presentation and the typical audiometric tracings among patients with presbycusis. Methods: This descriptive, prospective hospital-based study was conducted in the Ear, Nose and Throat (ENT) clinic of Olabisi Onabanjo University Teaching Hospital, (OOUTH) Sagamu, Nigeria. Patients with clinical diagnosis of presbycusis confirmed with bilateral sensorineural hearing loss (SNHL) on diagnostic audiometry were administered with questionnaires. Information obtained was analyzed using SPSS statistical package version 17.0 and presented in descriptive forms as percentages, means and graphs. Results: Sixty-nine patients were diagnosed with presbycusis (M:F =1.6:1). Modal age group was 71-80 years. Hearing loss 88.4%, tinnitus 79.7% and vertigo 33.3% were the major symptoms on presentation. The average duration of symptoms before presentation was 2.6 years. There was positive history of ototoxic drugs usage in 24.6 %, family history in 11.6 %, hypertension in 34.8% and osteoarthritis in 13.0%. The most common type of audiometric pattern was strial. Hearing losses increased with age both at the speech and at the higher frequencies of sounds. Conclusions: We found hearing impairment affected both speech and higher frequencies and the strial type of audiometric pattern was most common. The need for screening for hearing impairment from early middle age in symptomatic individuals is emphasized.

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Analgesic Use and the Risk of Hearing Loss in Men

Abstract: Background-Hearing loss is a common sensory disorder, yet prospective data on potentially modifiable risk factors are limited. Regularly used analgesics, the most commonly used drugs in the US, may be ototoxic and contribute to hearing loss.

Cited by 76 publications

References 54 publications

Duration of Analgesic Use and Risk of Hearing Loss in Women

Duration of Analgesic Use and Risk of Hearing Loss in Women

A Prospective Study of Cardiovascular Risk Factors and Incident Hearing Loss in Men

Clinical and audiometric features of presbycusis in Nigerians

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