Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice

Central administrations of hemopressin and related peptides inhibit gastrointestinal motility in mice

“…Taking into account their potency, WIN55,212‐2 displayed a much higher potency than hemopressin and related peptides. The results seem to agree with the data obtained from the recent nociceptive studies . When given i.c.v., WIN55,212‐2 showed highly potent antinociception than hemopressin or VD‐Hp α in the mouse tail flick assays .…”

“…In addition, hemopressin also produced anorectic activities, hypotensive actions, and anxiogenic‐like effects . Recently, our studies indicated that VD‐Hp α exhibited antinociception, hypotension, hypothermia, hypoactivity, conditioned place aversion, and orexigenic effects …”

“…Furthermore, hemopressin and related peptides were involved in several biological functions, such as pain modulation, cardiovascular actions, and food intake . Hemopressin was reported to induce antinociceptive effects in acute and chronic pain models after central and systemic administrations . In addition, hemopressin also produced anorectic activities, hypotensive actions, and anxiogenic‐like effects .…”

“…[3][4][5] Hemopressin was reported to induce antinociceptive effects in acute and chronic pain models after central and systemic administrations. 1,6,7 In addition, hemopressin also produced anorectic activities, hypotensive actions, and anxiogenic-like effects. 3,8,9 Recently, our studies indicated that VD-Hpa exhibited antinociception, hypotension, hypothermia, hypoactivity, conditioned place aversion, and orexigenic effects.…”

Caracterização da hemopressina (agonista inverso de receptores canabinóides do tipo 1) na neuropatia diabética experimental.

“…Em conjunto esses dados sugerem que a Hp possa atuar como um "neuropeptídeo não clássico" a exemplo das hemorfinas, peptídeos derivados das cadeias α e β da hemoglobina que interagem com receptores opióides (Brantl et al, 1986). Dados recentes da literatura sugerem que um mecanismo comum está envolvido na antinocicpção induzida por Hp, VD-Hemopressina e WIN55,212-2 (Pan et al, 2014).…”