Analgesic-like Activity of Essential Oils Constituents

Abstract

Research on neuroactive drugs is a pharmaceutical sector of high interest and growth. The discovery of efficient drugs that can relieve pain is a subject of research in the pharmaceutical industry and academic field because pain is a symptom of many diseases. This review will summarize results on the discovery of essential oil constituents with analgesic-like activity from the chemical and pharmacological perspectives. Overall, 43 bioactive compounds were selected in nociception models. Among them, 62.8% were monoterpenes, 18.6% sesquiterpenes and other constituents represented 18.6%. The data show the potential of this group of natural product chemicals as analgesic drugs that may be useful for therapeutic purposes.

The anti-hyperalgesic and anti-inflammatory profiles ofp-cymene: Evidence for the involvement of opioid system and cytokines

“…In addition, it is also a major cause of work disability. A significant portion of the world population is affected by some kind of pain, causing loss of good quality of life (De Sousa, 2011). Thus, treatment of painful disorders of various types continues to be a challenge to modern medicine.…”

Topical Analgesic Activity of Essential Oil Extracted From Spharenthus Indicus (Asteraceae)

“…They can penetrate the blood-brain barrier and act in the central nervous system [24]. The hot-plate test characterizes the central analgesic activity of the oil [25].…”

Evaluation of Antiproliferative and Antileishmanial Activities of R-(+)- limonene-derived 2-Amino-5-aryl-1,3,4-thiadiazoles

“…1,2 Dentre as diferentes classes de produtos naturais, os terpenos, compostos encontrados em plantas e comumente associados com óleos essenciais destacam-se por apresentarem diferenciadas propriedades farmacológicas. Muitos desses possuem propriedades analgésicas, 3 antiinflamatórias, 4 antibacterianas, 5 antifúngicas, 6 antiprotozoárias, [7][8][9] antioxidante 10 além de relevante atividade antitumoral.…”

“…13 C, IV, massas e % C,H,N. 3 , 75.5 MHz,): d=166.9 (C, C-2), 158.1 (C, C-5),134.3 (CH, C-4'), 131.2 (C, C-1''), 129.9 (CH, C-4''), 129.1( CH, C-3'', C-5''), 127.0 (CH, C-2'', C-6''), 120.5 (CH, C-3''), 58.3 (C, C-7'), 41.4 (CH, C-1'), 31.2 (CH 2 , C-5'), 26.9 (CH 2 ,C-2'), 24.5 (CH 3 , C-9), 24.3 (CH 2 , C-6'), 23.5(CH 3 , C-10'), 24 (C, C-1''), 127.0 (2 CH, C-2'',C-6''), 120.3 (CH, C-3'), 59.1 (C, C-7'), 41.6 (CH, C-1'), 31.2 (CH 2 , C-5'), 26.9 (CH 2 , C-2'), 24.5 (CH 3 , C-9'), 24.3 (CH 2 , C-6'), 23.9 (CH 3 , C-8'), 23. . C, C-2), 161.0 (C, C-4''), 158.2 (C, C-5), 134.4 (C, C-4'), 128.4 (2 CH, C-2'', C-6''), 124.0 (C, C-1''), 120.5 (CH, C-3'), 114.5 (2 CH, C-3'', C-5''), 58.3 (OCH 3 ), 55.6 (C, C-7'), 41.4 (C, C-1'), 31.2 (CH 2, C-5'), 26.9 (CH 2 , C-2'), 24.5 (CH 3 , C-9'), 24.3 (CH 2 , C-6'), 23.9 (CH 3 , C-8'), 23. .…”