Analgesic, hemodynamic and respiratory effects of caudal epidurally administered ropivacaine hydrochloride solution in mares

Skarda, R; Ww, Muir

doi:10.1016/s1467-2987(16)31363-0

Cited by 33 publications

(68 citation statements)

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“…Sie werden für kaudale Epiduralanästhesien oder kaudale subarachnoidale Anästhesien statt Lokalanästhetika angewandt (Fikes et al 1989, Green und Santacono 1996, LeBlanc et al 1988, LeBlanc und Caron 1990, LeBlanc und Eberhart 1990, Skarda und Muir 1983, Skarda und Muir 1996, Wagner und Muir 1991. In den meisten Arbeiten wird die analgetische Wirkung von Xylazin oder Detomidin mit Hilfe von niedrigen Stromstößen , LeBlanc et al 1988, Skarda und Muir 1991, Skarda und Muir 1994, Skarda und Muir 1996, Zwicken mit einer Klemme ) oder mit Nadelstichen (Fikes et al 1989, LeBlanc und Eberhart 1990, Skarda und Muir 1991 Bei unseren Pferden konnte der Katheter ohne Schwierigkeiten gelegt werden. Andere Autoren berichten , dass eine subarachnoidale Katheterisierung im lumbosakralen Bereich schwierig sei und dass, obwohl sie die arachnoidale Membran perforierten und cerebrospinale Flüssigkeit ablief, die Kanüle nicht ausreichend in den Subarachnoidalraum hineingebracht werden konnte.…”

Section: Materials Und Methodeunclassified

“…4-5 Minuten beobachten. Das stimmt mit den Angaben in der Literatur überein (Grubb et al 1992, LeBlanc und Eberhart 1990, McKinnon und Carnevale 1989, Skarda und Muir 1983, Skarda und Muir 1991, Skarda und Muir 1994, Skarda und Muir 1996. Skarda und Muir (1994) stellten im Anschluss an eine subarachnoidale Verabreichung von 30 µg/kg K.M.…”

Section: Materials Und Methodeunclassified

“…Es wurde festgestellt, dass Xylazin nur die sensiblen Nerven beeinflusst, ohne die motorischen Funktionen der Hintergliedmassen zu blokkieren und somit keine Ataxie verursacht. Diese α 2 -Adrenorezeptoren-Blocker schalten nach Injektion in den Epiduralraum den Schmerz deshalb aus, da sie die Freilassung spinaler Neurotransmitter reduzieren (Fikes et al 1989, Grubb et al 1992, Jean et al1990, LeBlanc et al 1988, LeBlanc und Caron 1990, LeBlanc und Eberhart 1990, Skarda und Muir 1996. In anderen Arbeiten (Fikes et al 1989, LeBlanc und Eberhart 1990, Skarda und Muir 1996 wurde die Anästhesiedauer und analgetische Wirkung von Lidocain und Xylazin miteinander verglichen.…”

Section: Introductionunclassified

“…Die Schmerzausschaltung in der Flanke bei Pferden kann mit der segmentalen thorakolumbalen subarachnoidalen Anästhe-sietechnik in Höhe von T 18 -L 1 erreicht werden. Hierfür werden 1,5-2 ml 2% Lidocain oder Mepivacain verwendet (Skarda 1987, Skarda und Muir 1996. Ziel der vorliegenden Studie war es, die Wirkung der subarachnoidalen Anästhesie in Höhe T 18 -L 1 mit Detomidin zur Schmerzausschaltung bei der laparoskopisch durchgeführten Ovariektomie bei Stuten zu überprüfen.…”

Section: Introductionunclassified

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Investigation of subarachnoid thoraco-lumbar anaesthesia with Detomidine in the horse

Seyrek-İntaș¹,

Topal²,

Seyrek-İntaş³

et al. 2001

PHK

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ZusammenfassungIn dieser Studie wurde die Wirkung zwischen subarachnoidal appliziertem Detomidin und lokaler Infiltrationsanästhesie in der Flanke für die laparoskopische Ovariektomie bei 20 Stuten miteinander verglichen. Bei insgesamt sieben Stuten (Gruppe 1) wurden 30 µg/kg und 40 µg/ kg Detomidin mit Hilfe einer Huber point Touhy Kanüle in den lumbosakralen Zwischenraum eingeführten und bis zum thorakolumbalen Bereich vorgeschobenen Katheters injiziert. Bei weiteren 13 Stuten (Gruppe 2-Kontrolle) wurde im Anschluss an eine Sedation, mit 20-30 ml 2% Mepivacain eine Infiltrationsanästhesie in der Flanke durchgeführt. Die Ergebnisse dieser Untersuchung zeigen, dass eine Dosis von 30 µg/kg subarachnoidal appliziertem Detomidin in der Flanke keine Anästhesie hervorruft, dass bei einer Dosis von 40 µg/kg eine gewisse anästhetische Wirkung vorhanden ist, für einen chirurgischen Eingriff jedoch nicht ausreicht.Schlüsselwörter: Subarachnoidale Anästhesie, Detomidin, Infiltrationsanästhesie, Ovariektomie, Stute. Investigation of subarachnoid thoraco-lumbar anaesthesia with Detomidine in the horseIn this study the effect of subarachnoid applicated Detomidine and local infiltration anaesthesia in the flank for laparoscopic ovariectomy was compared in 20 Turkish native mares. In a total of seven mares (group 1) 30 µg/kg and 40 µg/kg Detomidine was administered by a catheter, placed with a Huber point Touhy cannula through the lumbosacral space, and pushed forward to the thoraco-lumbar region. The other 13 mares (group 2-control) were sedated and then infiltration anaesthesia in the flank was performed with 20-30 ml 2 % Mepivacain. In both groups physiologic parameters and blood values were measured before and during anaesthesia (15, 30, 45, 60, 75, 90, 120 and 150 minutes). The results of this study showed that a dose of 30 µg/kg subarachnoid applied Detomidine induces no anaesthesia and that a dose of 40 µg/ kg has a certain anaesthetic effect but is not sufficient for a surgical intervention. The anaesthetic effect of locally infiltrated Mepivacain in the region of incision and in the suspensory ligaments of the ovaries is sufficient to remove the ovaries and no pain during operation was observed.

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Section: Materials Und Methodeunclassified

Section: Introductionunclassified

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Investigation of subarachnoid thoraco-lumbar anaesthesia with Detomidine in the horse

Seyrek-İntaș¹,

Topal²,

Seyrek-İntaş³

et al. 2001

PHK

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“…Xylazine (XYL) and acepromazine (ACP) are commonly administered in horses as preanesthetic medication, which significantly decreases hematocrit (HT) by relaxation of the splenic capsule, vasodilation on this organ and subsequent sequestration of red blood cells 1,2,3,4,5,6 . Despite HT decrease is expected after administration of XYL and ACP, in routine anesthesia they are often administered associated with other drugs based on the concept of balanced anesthesia, which is not known if may result in a different effect on HT.…”

Section: Introductionmentioning

confidence: 99%

Redução significante dos valores de hematócrito em equinos saudáveis durante anestesia

Ambrósio

Ida

Souto

et al. 2012

Braz. J. Vet. Res. Anim. Sci.

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Xylazine (XYL) and acepromazine (ACP) are known to decrease the hematocrit (HT) of horses when administered alone. However in routine anesthesia these drugs are administered by associations which ultimate effect in the HT is unknown but may cause false impressions about the hydration status, blood loss and red blood cell indices. The objective of this study was to characterize the values of HT in horses anesthetized with XYL, ACP, ketamine, midazolam, guaiphenesin, isoflurane and ephedrine. Twenty healthy horses were premedicated with either XYL 0.8 mg/kg (XYL group, n=10) or XYL 0.5 mg/kg plus ACP 0.05 mg/kg (XYL+ACP group, n=10). Anesthesia was induced with ketamine, midazolam and guaiphenesin and maintained with isoflurane. Ephedrine was infused for cardiovascular support. HT, vital parameters and blood gas values were evaluated at baseline, between each drug administration, after standing and 24 hours after baseline (24hBL). The HT started to decrease 17 and 40 minutes after premedication in XYL group and XYL+ACP group, respectively (p<0.05). The maximum decrease of 19% in XYL group and 17% in XYL+ACP group was observed after 1 hour of premedication (p<0.05). In both groups HT remained low for longer than 180 minutes and returned to baseline at 24hBL. A significant HT decrease should be considered in anesthetized healthy horses receiving XYL, ACP, ketamine, midazolam, guaiphenesin, isoflurane and ephedrine.Keywords: Horse. Hematocrit. Packed cell volume. Xylazine. Acepromazine. ResumoA administração isolada de xilazina (XIL) e acepromazina (ACP) pode diminuir o hematócrito (HT) de equinos. Na rotina anestésica, estes fármacos são administrados em associações, cujo efeito final no HT não é conhecido, mas pode causar falsas impressões sobre o grau de hidratação, perda sanguínea e índices hematimétricos. O objetivo deste estudo foi caracterizar os valores de HT de equinos anestesiados com XYL, ACP, cetamina, midazolam, EGG, isofluorano e efedrina. Vinte equinos hígidos foram pré-tratados com XIL 0,8 mg/kg (grupo XIL, n=10) ou XIL 0,5 mg/kg associada à ACP 0,05 mg/kg (grupo XIL+ACP, n=10). A anestesia foi induzida com cetamina, midazolam e EGG e mantida com isofluorano. A efedrina foi utilizada para suporte cardiovascular. O HT, parâmetros vitais e hemogasometria foram avaliados no momento basal, entre administração de cada fármaco, após retorno à posição quadrupedal e 24 horas após momento basal (24hBL). A diminuição do HT iniciou-se 17 e 40 minutos após administração da medicação pré-anestésica no grupo XIL e grupo XIL+ACP, respectivamente (p<0,05). A queda máxima de 19% no grupo XIL e 17% no grupo XIL+ACP foi observada após 1 hora da administração da medicação pré-anestésica (p<0,05). Em ambos os grupos, o HT permaneceu baixo por mais de 180 minutos e retornou aos valores basais em 24hBL. Deve-se considerar a ocorrência de uma redução significativa do HT em equinos hígidos anestesiados com XYL, ACP, cetamina, midazolam, EGG, isofluorano e efedrina.Palavras-chave: Equino. Hematócrito. Volume Globular. ...

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Clinicophysiological Effects of Spinally Administered Ketamine and Its Combination with Xylazine and Medetomidine in Healthy Goats

et al. 2007

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The study was conducted in 9 healthy adult goats of either sex, weighing 15-20 kg, to evaluate and compare the clinicophysiological effects of spinally administered ketamine alone and in combination with xylazine and medetomidine. Nine trials each of the three treatments were conducted randomly by injecting ketamine (2.5 mg/kg) (n = 9), ketamine and xylazine (2.5 mg/kg and 0.05 mg/kg) (n = 9) and ketamine and medetomidine (2.5 mg/kg and 10 microg/kg) (n = 9). The drugs were administered at the lumbosacral subarachnoid space under strict aseptic conditions. The treatments were evaluated on the basis of clinicophysiological, haematological, biochemical and haemodynamic observations. Ketamine produced mild to moderate analgesia of the hindquarters. Its combination with either xylazine or medetomidine produced complete analgesia of the hindquarters for 45-60 min. Ataxia was moderate in the ketamine group, whereas animals attained sternal recumbency in the combination groups. A moderate degree of sedation was recorded in the combination groups. Heart rate and respiratory rate depression in the combination groups and heart rate and respiratory rate stimulation in ketamine group were recorded. Haematological parameters decreased in all the groups. Increase in serum glucose, creatinine and urea nitrogen was recorded in all the groups. Serum electrolytes did not show any significant change. The results showed that the combination of ketamine with xylazine or medetomidine at these dose rates produced a comparable degrees of analgesia of hindquarters with transient and minimal cardiopulmonary side effects.

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Analgesic, hemodynamic and respiratory effects of caudal epidurally administered ropivacaine hydrochloride solution in mares

Cited by 33 publications

References 0 publications

Investigation of subarachnoid thoraco-lumbar anaesthesia with Detomidine in the horse

Investigation of subarachnoid thoraco-lumbar anaesthesia with Detomidine in the horse

Redução significante dos valores de hematócrito em equinos saudáveis durante anestesia

Clinicophysiological Effects of Spinally Administered Ketamine and Its Combination with Xylazine and Medetomidine in Healthy Goats

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