Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta‐analysis

Abstract

Post-Market Research Clinical evidence supports the use of dexketoprofen trometamol (DEX) to manage acute postoperative pain. However, controversies surround the impact of the use of this drug in preoperative analgesic protocols. The aim of the present meta-analysis was to evaluate the effectiveness of the preoperative administration of DEX under postoperative pain conditions. Electronic and manual searches were conducted through diverse electronic databases. A systematic review and meta-analysis to evaluate the analgesic efficacy of the preoperative administration of DEX was performed including Randomized Clinical Trials (RCTs) published between 2002 and 2017. Suitable individual studies were evaluated through a quality system, and the data were extracted and analyzed. Fourteen RTCs were included (12 parallel trials and 2 cross-over trials), published in the English and Turkish languages. Follow-up periods ranged from 4, 6, 8, 24, and 48 hr. All trials measured the outcome result as Acute Pain Level (APL) (VAS, NRS, VRS), time to requiring a second dose of DEX or analgesic emergency and consumption of opioids via patient-controlled analgesia. When the comparators were other drugs - paracetamol, Lornoxicam or placebo during the preoperative time, preoperative administration of DEX was superior. When the comparison comprised preoperative and postoperative DEX, both alternatives exhibited comparable analgesic effects. The analgesic efficacy of the preoperative administration of DEX when compared to placebo, lornoxicam, and paracetamol on postoperative pain was evident. Preoperative administration of DEX compared to its immediate postoperative administration showed a similar analgesic effect.

Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma

“…Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has been prescribed as an analgesic, anti-pyretic, and antiinflammatory agent since 1973 (Esparza-Villalpando1, Pozos-Guillén, Masuoka-Ito, Fonseca, & Chavarría-Bolanos, 2018;Sweetman, 2003).…”

Principles of choosing an analgesic depending on the intensity of pain

“…Несприятливі події, пов'язані з аналгезією, зустрічалися рідше -в 16 % пацієнтів у групі декскетопрофену порівняно з групою кетопрофену (21,3 %). В іншому дослідженні [17] продемонстровані переваги передопераційного введення декскетопрофену порівняно з плацебо, лорноксикамом і парацетамолом за оцінкою післяопераційного болю.…”

Analgesic Drugs and Cardiac Safety

“…Another systematic review on the risk of myocardial infarction in patients treated with NSAIDs and coxibs has demonstrated a 10% increase in MI risk with the use of NSAIDs, with differences between the drugs; diclofenac showed an increased risk of 44% and rofecoxib an increased risk of 30% [137]. Systematic reviews on the clinical use of dexketoprofen suggest that this drug does not interfere with the CVS [138,139]. Similar results have been obtained with the use of a fixed-dose combination of dexketoprofen and tramadol [140].…”