Analgesic Efficacy of Ketoprofen in Postpartum, General Surgery, and Chronic Cancer Pain

Sunshine, Abraham; Olson, Nancy Z.

doi:10.1002/j.1552-4604.1988.tb05977.x

Cited by 59 publications

(23 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typically, very large doses of NSAIDs are used to inhibit pain-related behaviors in a variety of models of persistent pain 28. In postoperative patients, much smaller doses of NSAIDS are used 2,29–32…”

Section: Discussionmentioning

confidence: 99%

“…Ketoprofen has been used for the treatment of postoperative pain in patients 2. Ketoprofen, in doses of 1 to 2 mg/kg, consistently reduces pain and/or opioid requirements after many types of surgeries 2–7.…”

Section: Introductionmentioning

confidence: 99%

“…Ketoprofen, in doses of 1 to 2 mg/kg, consistently reduces pain and/or opioid requirements after many types of surgeries 2–7. In contrast, when ketoprofen is used in rodent postoperative studies, much larger doses (5–100 mg/kg) are administered 8–11.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision

Spofford¹,

Ashmawi²,

Subieta³

et al. 2009

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

Background Postoperative pain remains a significant problem despite optimal treatment with current drugs. Nonsteroidal antiinflammatory drugs reduce inflammation and provide analgesia, but are associated with adverse side effects. Methods We tested low doses (0.5 – 5 mg/kg) of parenteral ketoprofen against pain related behaviors after plantar incision in rats. To further evaluate the potential sites of action of ketoprofen in our model, a novel, sustained-release microparticle formulation of ketoprofen was placed into the wound, and tested for its effects on pain behaviors. Intrathecal ketoprofen (150 mcg) was also studied. Plasma samples were assayed for drug concentrations. Results We found that low doses of parenterally administered ketoprofen produced a modality specific effect on pain behaviors; guarding after incision was decreased, whereas no inhibition of exaggerated responses to heat or mechanical stimuli was evident. Very low doses, 0.5 mg/kg, could produce inhibition of guarding. The locally applied sustained release ketoprofen-eluting microparticles and intrathecally administered ketoprofen also produced a modality-specific effect on pain behaviors after incision, inhibiting only guarding. Plasma levels of ketoprofen after parenteral or local administration were in the range of therapeutic blood levels in postoperative patients. Conclusions This study demonstrates that ketoprofen is an effective analgesic for nonevoked guarding in rats after plantar incision. There was no effect on mechanical or heat responses, which highlights the importance of multiple modality testing of pain behaviors for drug evaluation. We found efficacy at doses used clinically in postoperative patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision

Spofford¹,

Ashmawi²,

Subieta³

et al. 2009

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

show abstract

“…Skin pain may also play an alone for post-operative pain [11,15], but few have important role. All these factors may explain the atypconfirmed this property in general surgery [16], orthopaedic surgery [17] or ESWL [18]. Paracetamol (an ical features which have been reported.…”

Section: Discussionmentioning

confidence: 96%

Effect of Balanced Analgesia With Buprenorphine on Pain Response and General Anaesthesia Requirement During Lithotripsy Procedures

Tauzin-Fin¹,

Delort-Laval²,

Krol-Houdek³

et al. 1999

Journal of Urology

View full text Add to dashboard Cite

pain; and (2) intense pain needing general anaesthesia. The patients assessed their pain intensity on a The effectiveness of a balanced analgesia with bu-0-100 mm visual analogue scale. Only 69% of group prenorphine ketoprofen-propacetamol for pain control 1 patients received ESWL with midazolam preduring extracorporeal shock wave lithotripsy (ESWL) medication. Buprenorphine provided good analgesia was evaluated in order to reduce the requirements in 87% of group 2 patients, while the combination for general anaesthesia. Two hundred and ninety-one buprenorphine-ketoprofen-propacetamol was effectconsecutive patients were included in a randomized, ive in 99% of group 3 patients (P<0.05). The incidence placebo-controlled, double-blind study. Patients in of nausea and vomiting was similar in the bueach group received midazolam 5 mg pre-operatively prenorphine groups. No respiratory depression was as premedication. The subjects then received either reported. In conclusion, the buprenorphine-keplacebo (group 1), buprenorphine 0.3 mg (group 2) or toprofen-propacetamol combination provided effectthe combination buprenorphine 0.3 mg plus ketoive analgesia, allowing ESWL to be performed without profen 100 mg and propacetamol 2 g (group 3) intrathe need for general anaesthesia. venously (i.v.) at a constant rate. The treatment was started 45 min prior to ESWL. Pain was assessed using

show abstract

“…Although buprenorphine analgesia significantly reduced the incidence of pain and vagal reaction to 6% and 7%, respectively, it did not preclude the need for general anaesthesia. Many studies have demonstrated the efficacy of NSAIDs used alone for post‐operative pain [11,15], but few have confirmed this property in general surgery [16], orthopaedic surgery [17] or ESWL [18]. Paracetamol (an antipyretic analgesic) and ketoprofen (an NSAID) exert a central action, irrespective of endogenous opioids, as well as a peripheral action.…”

Section: Introductionmentioning

confidence: 99%

Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures

et al. 1998

View full text Add to dashboard Cite

The effectiveness of a balanced analgesia with buprenorphine ketoprofen-propacetamol for pain control during extracorporeal shock wave lithotripsy (ESWL) was evaluated in order to reduce the requirements for general anaesthesia. Two hundred and ninety-one consecutive patients were included in a randomized, placebo-controlled, double-blind study. Patients in each group received midazolam 5 mg pre-operatively as premedication. The subjects then received either placebo (group 1), buprenorphine 0.3 mg (group 2) or the combination buprenorphine 0.3 mg plus ketoprofen 100 mg and propacetamol 2 g (group 3) intravenously (i.v.) at a constant rate. The treatment was started 45 min prior to ESWL. Pain was assessed using a three-point verbal scale: (0)no pain; (1) moderate pain; and (2) intense pain needing general anaesthesia. The patients assessed their pain intensity on a 0-100 mm visual analogue scale. Only 69% of group 1 patients received ESWL with midazolam premedication. Buprenorphine provided good analgesia in 87% of group 2 patients, while the combination buprenorphine-ketoprofen-propacetamol was effective in 99% of group 3 patients (P < 0.05). The incidence of nausea and vomiting was similar in the buprenorphine groups. No respiratory depression was reported. In conclusion, the buprenorphine-ketoprofen-propacetamol combination provided effective analgesia, allowing ESWL to be performed without the need for general anaesthesia.

show abstract

Analgesic Efficacy of Ketoprofen in Postpartum, General Surgery, and Chronic Cancer Pain

Cited by 59 publications

References 8 publications

Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision

Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision

Effect of Balanced Analgesia With Buprenorphine on Pain Response and General Anaesthesia Requirement During Lithotripsy Procedures

Effect of balanced analgesia with buprenorphine on pain response and general anaesthesia requirement during lithotripsy procedures

Contact Info

Product

Resources

About