Effect of Balanced Analgesia With Buprenorphine on Pain Response and General Anaesthesia Requirement During Lithotripsy Procedures

Abstract

pain; and (2) intense pain needing general anaesthesia. The patients assessed their pain intensity on a The effectiveness of a balanced analgesia with bu-0-100 mm visual analogue scale. Only 69% of group prenorphine ketoprofen-propacetamol for pain control 1 patients received ESWL with midazolam preduring extracorporeal shock wave lithotripsy (ESWL) medication. Buprenorphine provided good analgesia was evaluated in order to reduce the requirements in 87% of group 2 patients, while the combination for general anaesthesia. Two hundred and ninety-one buprenorphine-ketoprofen-propacetamol was effectconsecutive patients were included in a randomized, ive in 99% of group 3 patients (P<0.05). The incidence placebo-controlled, double-blind study. Patients in of nausea and vomiting was similar in the bueach group received midazolam 5 mg pre-operatively prenorphine groups. No respiratory depression was as premedication. The subjects then received either reported. In conclusion, the buprenorphine-keplacebo (group 1), buprenorphine 0.3 mg (group 2) or toprofen-propacetamol combination provided effectthe combination buprenorphine 0.3 mg plus ketoive analgesia, allowing ESWL to be performed without profen 100 mg and propacetamol 2 g (group 3) intrathe need for general anaesthesia. venously (i.v.) at a constant rate. The treatment was started 45 min prior to ESWL. Pain was assessed using