Analgesic, Anti-inflammatory and CNS Depressant Activities of the Methanolic Extract of Abelmoschus esculentus Linn. Seed in Mice

Nesa, Mst. Luthfun

doi:10.9734/bjpr/2014/7845

Cited by 19 publications

(16 citation statements)

References 27 publications

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“…Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system [25]. Earlier investigation has also demonstrated that phenolic acids such as epicatechin were found to be ligands for the GABA A receptors in the central nervous system [26], which led to assumption that they can act as benzodiazepine-like molecules.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from the Methanol Extract ofCnicus arvensis(L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice

Rahman

Khatun

Nesa

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Cnicus arvensis is used by many ethnic groups for inflammation, pain, and other ailments. In this study, reducing sugar, carbohydrate, alkaloid, steroid, tannin, flavonoid, and saponin groups were identified using standard chromogenic method. In high-performance liquid chromatography, vanillic acid and epicatechin were identified in the extract. Antinociceptive test by acetic acid induced writhing inhibition resulted 43.17 and 95.08% inhibition for 100 and 200 mg/kg body weight, comparing with standard diclofenac Na with 74.86% inhibition for 25 mg/kg body weight. In formalin induced paw licking test for antinociceptive activity, the extract inhibited 69.87 and 75.55% licking for 150 and 300 mg/kg body weight comparing with the inhibition (68.56%) of diclofenac Na for 10 mg/kg body weight at first phase. At late phase, the extract showed 73.12 and 87.46% licking comparing with licking inhibition (71.69%) by diclofenac Na at the same dose. In open field test for CNS depressant activity, the extract showed depression of locomotor activity for 150 and 300 mg/kg body weight comparing with diazepam for 10 mg/kg body weight. All results were statistically significant (P < 0.01). The identified polyphenols are reputed for antinociceptive and CNS depressant activity. The present findings support the use of this plant in pain.

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Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from the Methanol Extract ofCnicus arvensis(L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice

Rahman

Khatun

Nesa

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…Rearing behaviour in mice is regulated by multiple neurotransmitter systems including GABAergic (GABA A ), opioidergic and dopaminergic (D 2 ) systems and receptors [ 36 ]. Locomotor activity in experimental animals are generally reduced by central nervous system (CNS) depressants and increased by CNS stimulants [ 37 , 38 ]. Drug-induced decrease in locomotion of experimental animals may be due to decreased motor effects and/or increased sedation [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis

Amoateng

Adjei

Osei‐Safo

et al. 2017

BMC Complement Altern Med

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BackgroundThe hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting antipsychotic potential. Coupled with the central nervous system depressant effects of SNE, we hypothesized that it may have utility in the management of psychosis. The present study therefore investigated the antipsychotic potential of the SNE in several murine models of psychosis.MethodThe primary central nervous system activities of SNE (30–3000 mg/kg, p.o) were investigated using the Irwin’s test. The novelty-induced rearing, locomotion and stereotypy counts provoked by SNE (100–1000 mg/kg, p.o) were conducted using the open-field paradigm. The antipsychotic test models used in the screening of SNE (100–1000 mg/kg, p.o) included apomorphine-induced stereotypy, rearing, locomotion and cage climbing activities. The combined effects of a low dose of SNE (100 mg/kg) with various doses of haloperidol and chlorpromazine were analysed using the apomorphine-induced cage climbing and stereotypy, respectively. The ability of SNE to cause catalepsy in naïve mice as well as its effect on haloperidol-induced catalepsy was assessed.ResultsSNE showed acetylcholine-like and serotonin-like activities in the Irwin test, with sedation occurring at high doses. SNE significantly reduced the frequencies of novelty- and apomorphine-induced rearing and locomotion; stereotypy behaviour and the frequency and duration of apomorphine-induced cage climbing in mice. In all the tests performed, SNE was less potent than the reference drugs used (chlorpromazine and haloperidol). In addition, SNE potentiated the effects of haloperidol and chlorpromazine on apomorphine-induced cage climbing and stereotypy activities in mice.ConclusionSNE, while exhibiting antipsychotic properties itself, can also potentiate the antipsychotic effects of chlorpromazine and haloperidol.

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“…Group 4 and Group 5 received C. sativum leaves extract at the dose of 100 mg/kg and 200 mg/kg body weight orally, respectively. Group 6 received diclofenac sodium 10 mg/kg body weight orally and served as the standard control [14]. The numbers of contraction of the abdominal muscles together with stretching of hind limbs (writhes) were noted for 30 min, and percent inhibition of writhing was also calculated.…”

Section: Peripheral Analgesic Activitymentioning

confidence: 99%

Evaluation of Analgesic Activity of Murraya Koenigii and Coriandrum Sativum Leaves Extract in Animal Model.

J¹,

Mirunalini²,

Mano³

et al. 2018

Asian J Pharm Clin Res

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Objective: The objective of the study was to investigate the analgesic activity of hydroalcoholic extract of Murraya koenigii and Coriandrum sativum leaves and compared it with standard drug in an animal model. Methods:Hydroalcoholic extracts of M. koenigii and C. sativum leaves were obtained using Soxhlet apparatus. The central analgesic property was screened by hot plate method in mice and tail flick method in rats. The pain reaction time (PRT) was measured at 30, 60, and 120 min. The peripheral analgesic activity was evaluated by acetic acid induced writhing in mice. Results:In hot plate method M. koenigii leaves extract at both doses and tramadol showed significant increase in PRT at 30, 60, and 120 min compared with control group. C. sativum leaves extract showed significant increase in PRT only at 60 and 120 min compared to control group. In tail flick method M. koenigii leaves extract at both doses, higher dose of C. sativum leaves extract and tramadol showed significant increase in PRT at 30, 60, and 120 min compared with control group. Higher dose of M. koenigii leaves extract (200 mg/kg) was comparable with standard drug tramadol in both the methods. M. koenigii leaves extract at both dose showed significant reduction in the number of writhing but C. sativum leaves extract failed to show any significant reduction in the number of writhing compared with control. Higher dose of M. koenigii leaves extract was comparable with standard drug tramadol. Conclusion:M. koenigii leaves extract showed both peripheral and central analgesic effect while C. sativum leaves extract showed only peripheral analgesic effect.

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Analgesic, Anti-inflammatory and CNS Depressant Activities of the Methanolic Extract of Abelmoschus esculentus Linn. Seed in Mice

Cited by 19 publications

References 27 publications

Bioactive Polyphenols from the Methanol Extract ofCnicus arvensis(L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice

Bioactive Polyphenols from the Methanol Extract ofCnicus arvensis(L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice

Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis

Evaluation of Analgesic Activity of Murraya Koenigii and Coriandrum Sativum Leaves Extract in Animal Model.

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