Analgesic, Anti-inflammatory and Anti-ulcerogenic Activities of Fractions from Alstonia scholaris

Arulmozhi, S.; Mazumder, Papiya Mitra; Sathiyanar, L.; Thakurdesa, Prasad A.

doi:10.5567/pharmacologia.2012.132.137

Cited by 15 publications

(5 citation statements)

References 7 publications

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“…Several plants of family Apocynaceae are known for the in vitro and in vivo anti‐inflammatory activity. Arulmozhi, Mazumder, Sathiyanarayanan, and Thakurdesai () showed the potent anti‐inflammatory activity of dichloromethane fraction from ethanolic extract Alstonia scholaris leaves. Subraya and Gupta () studied in vivo anti‐inflammatory activity of Alstonia scholaris stem bark methanol extract in rat paw edema models.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Forskolin also acts as an aid to nerve regeneration following trauma. [1][2][3][4][5][6][7][8][9][10]…”

Section: Original Articlementioning

confidence: 99%

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Madoria¹

2021

IJGP

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“…Based on previous research of Arulmozhi [7] the dichlormethane (DCM) fraction of the ethanol extract of the leaves of the wood of pulai (Alstonia scholaris L) was shown to have analgesic and anti-inflammatory activity. Meanwhile, in this study, the bark of pulai was tested.…”

Section: Introductionmentioning

confidence: 99%

Activity Test of Ethanol Extract from Pulai Bark (Alstonia scholaris L.) Antiinflammation in Mice (Mus musculus)

Pratiwi¹,

Idawati²,

Rahmawati³

et al. 2022

Proceedings of the First International Conference on Medical Technology (ICoMTech 2021)

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Inflammation is a complex biological response of vascular tissue to noxious stimuli such as pathogens, damaged body cells, or irritants. The drugs commonly used are non-steroidal anti-inflammatory drugs. However, long-term use of non-steroidal anti-inflammatory drugs can cause ulceration and bleeding in the lower GI tract. So that alternative treatments that can be used are medicinal plants, one of which is the wood of pulai. Pulai bark (Alstonia scholaris L.) contains secondary metabolites of alkaloids, flavonoids, polyphenols, terpenoids and steroids. Flavonoids are able to provide anti-inflammatory effects. The aim of this study was to determine the anti-pain activity of the ethanol extract of the bark of the bark of pulai (Alstonia scholaris L.) on the inflammation of mice (Mus musculus). Extraction was carried out by continuous maceration method (remaceration) using 96% ethanol as solvent. Anti-pain testing on inflammation of mice using the true experimental method, mice were divided into 5 groups, namely the negative control group was given aquadest, the positive control was given 0.39 g/30-g BW of diclofenac sodium, the test group was given ethanol extract of pulai bark as much as 0.5 mL/30 g BW with a dose of 400 mg/kgBW, 200 mg/kgBW and 100 mg/kgBW. After 1 min, 1% acetic acid was induced at a dose of 10 mL/30 gBW. Observation of healing time was carried out by observing the stretching of the mice that had been given treatment, which was marked by reduced stretching of the mice. The data were analyzed statistically using the One Way Anova test. The data obtained showed that the ethanol extract of pulai bark at a dose of 400 mg/kgBW, 200 mg/kgBW and 100 mg/kgBW had an anti-pain effect on inflammation in mice. The effective dose as an anti-pain in inflammatory mice is a dose of 200 mg/kgBW.

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Analgesic, Anti-inflammatory and Anti-ulcerogenic Activities of Fractions from Alstonia scholaris

Cited by 15 publications

References 7 publications

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

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Activity Test of Ethanol Extract from Pulai Bark (Alstonia scholaris L.) Antiinflammation in Mice (Mus musculus)

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