Analgesic and Anti-inflammatory Effects of Methanolic Extract of Pausinystalia Macroceras Stem-Bark in Rodents

Nwafor, A Paul; Jacks, T. W.; Ekanem, AU

doi:10.3923/ijp.2007.86.90

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…The paw size of all the treated groups in this test decreased from the first hour post-oedema induction in a dose-dependent manner (125-500 mg/kg) as compared to the control group (Table 4). Oedema reduction in the treated groups increased with time, a finding that is supported by a previous study involving inhibition of egg albumin-induced oedema by an extract [25]. Our extract may have elicited its anti-inflammatory effect by inhibiting the release of histamine and 5-HT, two mediators that are released by egg albumin [26].…”

Section: Discussionsupporting

confidence: 86%

Anti-nociceptive and anti-inflammatory effects of the hydroethanolic extract of a polyherbal preparation (Cov-Pla 2) in laboratory animals

Amagon¹,

Falang²,

Bukar³

et al. 2021

J. Pharm Bio.

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Symptoms of Coronavirus Disease-2019 include pulmonary hyper-inflammation; managing local and systemic inflammatory responses may be key in treatment. This study evaluated the anti-inflammatory, analgesic and antipyretic effects of a mixture (Cov-Pla 2) containing five medicinal plants in laboratory animals. The antinociceptive activity of Cov-Pla 2 was evaluated using acetic acid-induced writhing, Brewer’s Yeast Pyrexia test in rats and hot plate tests in mice. The egg albumin-induced rat paw oedema test was employed to evaluate the extract’s anti-inflammatory activity. The extract produced a dose-dependent (125-500 mg/kg, p.o.) inhibition of pain response elicited by acetic acid, compared to normal saline and increased reaction latency in the hot plate test. The antiinflammatory test showed a significant (P<0.05) reduction in paw size diameter at 125 mg/kg from 2 hours, compared to control. In the antipyretic test, the extract produced a significant (P<0.05) time-dependent decrease in rectal temperature at 125 mg/kg after 2 and 3 hours and at 250 and 500 mg/kg after 3 hours, compared to normal saline. The extract did not produce mortality up to 5000 mg/kg per oral. The results indicated that the extract possesses antinociceptive and anti-inflammatory properties, which support its recommendation for trials in the treatment of symptoms associated with COVID-19. Keywords: COVID-19; Inflammation; Nociception; Polyherbal; SARS-CoV-2

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Section: Discussionsupporting

confidence: 86%

Anti-nociceptive and anti-inflammatory effects of the hydroethanolic extract of a polyherbal preparation (Cov-Pla 2) in laboratory animals

Amagon¹,

Falang²,

Bukar³

et al. 2021

J. Pharm Bio.

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show abstract

“…The extract significantly reduced acetic acid-induced writhing, formalin-induced hind paw licking and also delayed the reaction time of animals (mice) to thermally induced pain. Acetic acid causes inflammatory pain by inducing capillary permeability, 14,15 and in part intraperitoneally of PGE2 and PGF2α 16,17 The acetic acid-induced abdominal writhing is a visceral pain model in which the processor releases arachidonic acid and prostaglandin biosynthesis plays a role in the nociceptive mechanism. 18 It is used to distinguish between central and peripheral pain.…”

Section: Effect Of Ethanol Crude Extract Of S Officinarum On Thermally Induced Pain In Micementioning

confidence: 99%

Analgesic Activity of Ethanol Leaf Extract of Saccharum officinarum

2021

TJNPR

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Saccharum officinarum (Family-Poaceae) commonly known as sugarcane is widely cultivated throughout tropical and subtropical regions. In folkloric medicine it is used in the treatment of diarrhoea, dysentery, eye infirmities, fever, arthritis, bedsores, boils, cancer, colds, cough, opacity, skin sores, sore throat, hiccups, inflammation, laryngitis, spleen, tumors, and wounds. 1 Biological activities reported on the leaf include antibacterial and anthelmintic, 2 anti-hyperglycaemic, anti-hyperlipidaemic, 3 antioxidant, 34 Diuretic and antiurolithiatic, 5 antidepressant and anticonvulsant activities. 6 Phytochemical screening of leaf extract of S. officinarum reported the presence of glycosides, phytosterols, saponins, tannins, flavonoids. 2 The study reports the analgesic activity of S. officinarum leaf extract in mice.

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Antimalarial and analgesic activities of ethanolic leaf extract of Panicum maximum

Okokon

Nwafor

Andrew

2011

Asian Pacific Journal of Tropical Medicine

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Analgesic and Anti-inflammatory Effects of Methanolic Extract of Pausinystalia Macroceras Stem-Bark in Rodents

Cited by 7 publications

References 19 publications

Anti-nociceptive and anti-inflammatory effects of the hydroethanolic extract of a polyherbal preparation (Cov-Pla 2) in laboratory animals

Anti-nociceptive and anti-inflammatory effects of the hydroethanolic extract of a polyherbal preparation (Cov-Pla 2) in laboratory animals

Analgesic Activity of Ethanol Leaf Extract of Saccharum officinarum

Antimalarial and analgesic activities of ethanolic leaf extract of Panicum maximum

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