Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract of<i>Nyctanthes arbor-tristis</i>Linn.

Kakoti, Bibhuti Bhusan; Pradhan, P. C.; Borah, Sudarshana; Mahato, Kabita; Kumar, Manoj

doi:10.1155/2013/826295

Cited by 23 publications

(17 citation statements)

References 10 publications

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“…This is because such information holds guarantees for the finding of new therapeutic agents capable of inhibiting, decreasing, or relieving pain [ 16 – 28 ]. Plants characterize a vast natural supply of appreciated compounds that might achieve primary importance for the expansion of novel drugs [ 29 ]. The survey of the effectiveness of plant-based remedies used in the folk medicine has given great reflections because they are cheap and have reduced side effects.…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

219

132

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Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

219

132

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“…Many herbal preparations are being prescribed as anti-inflammatory and analgesic in the traditional literature [ 20 ]. The search for new anti-inflammatory and analgesic agents from the huge array of medicinal plant resources is intensifying [ 21 ]. Several drugs has been discovered to inhibit or delay the inflammation of rheumatoid or osteoarthritis by targeting anti-inflammatory protein COX-2.…”

Section: Discussionmentioning

confidence: 99%

Identification of human cyclooxegenase-2 inhibitors from Cyperus scariosus (R.Br) rhizomes

et al. 2014

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Cyperus scariosus (R.Br) belongs to the family Cyperaceae and it has a diverse medicinal importance. To identify human cyclooxegenase-2 (COX-2) inhibitors from C. scariosus, the rhizome powder was exhaustively extracted with various solvents based on the increasing polarity. Based on the presence and absence of secondary metabolites, we have selected the methanolic extract to evaluate the anti-oxidant and anti-inflammatory activity. The same extract was further subjected to gas chromatography-mass spectroscopy (GC-MS) analysis to identify the active compounds. Binding affinities of these compounds towards anti-inflammatory protein COX-2 were analyzed using molecular docking interaction studies. Phytochemical analysis showed that methanol extract is positive for all secondary metabolites. The antioxidant activity of the C. scariosus rhizomes methanolic extract (CSRME) is half to that of ascorbic acid at 50 µg/ml. The anti-inflammatory activity of CSRME is higher than that of diclofenac sodium salt at high concentration, which is evident from the dose dependent inhibition of bovine serum albumin denaturation at 40 µg/ml–5 mg/ml. GC-MS analysis showed the presence of nine compounds, among all N-methyl-1-adamantaneacetamide and 1,5,diphenyl-2H-1,2,4- triazine form a hydrogen bond interactions with Ser-530 and Tyr-385 respectively and found similar interactions with crystal structure of diclofenac bound COX-2 protein. Benzene-1, 2-diol, 4-(4-bromo-3 chlorophenyl iminomethyl forms hydrogen bond interactions with Thr-199 and Thr-200 as similar to crystallized COX-2 protein with valdecoxib. Collectively our results suggest that CSRME contains medicinally important anti-inflammatory compounds and this justifies the use of this plant as a folklore medicine for preventing inflammation associated disorders.

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“…Results showed that Nyctanthes arbortristis Linn. Had potent analgesic and anti-inflammatory activities (Kakoti et al, 2013).…”

Section: Exploration Of Anti-malassezia Potential Ofmentioning

confidence: 99%

Systemic Review on Anti-Sciatica Plant “Night Jasmine” (Nyctanthes arbortristis Linn.)

Kumar¹,

Rathi²,

Tyagi³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract ofNyctanthes arbor-tristisLinn.

Cited by 23 publications

References 10 publications

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Identification of human cyclooxegenase-2 inhibitors from Cyperus scariosus (R.Br) rhizomes

Systemic Review on Anti-Sciatica Plant “Night Jasmine” (Nyctanthes arbortristis Linn.)

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