Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis

Nesterova, Yu. V.; Povetyeva, T. N.; Суслов, Н. И.; Zyuz’kov, G. N.; Пушкарский, С. В.; Aksinenko, S. G.; Schultz, E. E.; Kravtsova, S. S.; Krapivin, A. V.

doi:10.1007/s10517-014-2598-6

Cited by 44 publications

(25 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neoline and fuziline have no direct cardiac effects for the isolated frog heart, but with respect to the heart failure cell model induced by sodium pentobarbital, various concentration solutions could recover the beat rhythm of cardiomyocytes and increase myocardial viability . Songorine, a member of the veatchine alkaloids, has been proven to have antinociceptive effects due to its affinity for opioid receptors . Another C‐19‐type alkaloid, also known as talatisamine, blocks the delayed rectifier K + channel by binding to its external pore entry site, suggesting that it has antiarrhythmic effects and plays a significant role in protecting cells during heart failure .…”

Section: Resultsmentioning

confidence: 99%

Investigation of the chemical markers for experiential quality evaluation of crude aconite by UHPLC–Q‐TOF‐MS

Zhang

Han

et al. 2016

J of Separation Science

View full text Add to dashboard Cite

Many foods and herbs are experientially classified into different commodity grades in commercial circulation. Regarding the hypertoxic herb aconite, large samples are considered to be of better quality. However, this experiential classification lacks a scientific basis. In this study, we focused on the quality diversity among different grades and studied it using the minimum lethal dose assay and a novel ultra high performance liquid chromatography coupled with time-of-flight mass spectrometry method. Toxicity assay result suggested grade I aconite had the lowest toxicity (p < 0.05). Using this method with partial least squares-discriminant analysis, we discovered nine chemomarkers, including neoline, songorine, fuziline, mesaconitine, talatizidine, dexyaconitine, talatisamine, hypaconitine, and fuzitine. Considering their toxicity and activity, we found the levels of toxic ingredients hypaconitine, dexyaconitine, and mesaconitine in grade I were lower than those in grade II (p < 0.01), while the levels of efficacy ingredients songorine, talatisamine, and neoline were the highest in grade I (p < 0.01). Further study demonstrated that the quality variation was associated with plant tissue development and toxic ingredient distribution law. Our results provide scientific evidence for the experiential quality evaluation of aconite, and it will be of great utility for other foods and herbs.

show abstract

Section: Resultsmentioning

confidence: 99%

Investigation of the chemical markers for experiential quality evaluation of crude aconite by UHPLC–Q‐TOF‐MS

Zhang

Han

et al. 2016

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…The detected analgesic activity of diterpene alkaloids from A. baikalensis was comparable to that of sodium metamizole (Nesterova et al, 2014). The mechanisms of analgesia were different in diterpene alkaloids of different structure.…”

Section: Effects On Nervous System Analgesic Activity and Neurotoximentioning

confidence: 69%

Chemical and biological studies of Aconitum pharmaceutical resources

Hao¹,

Gu²,

Xiao³

2015

Medicinal Plants

View full text Add to dashboard Cite

“…Murayama concluded that the analgesic activity of MA was dose‐dependent and was closely related to the noradrenergic system of the CNS . Also, hypaconitine, fuziline, neoline, songorine, and benzoylmesaconine from Fuzi displayed an obvious analgesic action . Fuziline alone had lower toxicity, with a maximum tolerated dose of 1 g/kg.…”

Section: Neuropharmacological Effect Of Aconiti Lateralis Radix Praepmentioning

confidence: 99%

“…So alkaloids might inhibit formalin‐induced behaviour by suppressing neuronal transmission . Nesterova reported that the antinociceptive effect of songorine was naloxone‐dependent and mediated by the opioid receptor . Moreover, Liou thought that the central opioid receptors mediate the analgesic effect of Yan‐Fuzi .…”

Section: Neuropharmacological Effect Of Aconiti Lateralis Radix Praepmentioning

confidence: 99%

Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

Zhao

Sun

Yang

et al. 2020

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Aconiti Lateralis Radix Praeparata (Fuzi in Chinese), which are the lateral roots of Aconitum Carmichaelii Debx, is widely used in China to treat many neurological diseases. Fuzi, in its various forms, has many neuropharmacological effects. It can act as an analgesic and help with depression, epilepsy, and dementia. However, the neuropharmacological effects of Aconiti Lateralis Radix Praeparata are seldom comprehensively reviewed. In this review, the neuropharmacological activities of some components contained in Aconiti Lateralis Radix Praeparata are considered. These include aconitine, mesaconitine, hypaconitine, total alkaloid, polysaccharide‐1, benzoylmesaconine, fuziline, songorine, and napelline. We also specifically discuss the antidepressant effects of total alkaloids and polysaccharide‐1. This review may provide a theoretical basis for further utilization of Aconiti Lateralis Radix Praeparata for diseases that affect the central nervous system.

show abstract

Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis

Cited by 44 publications

References 5 publications

Investigation of the chemical markers for experiential quality evaluation of crude aconite by UHPLC–Q‐TOF‐MS

Investigation of the chemical markers for experiential quality evaluation of crude aconite by UHPLC–Q‐TOF‐MS

Chemical and biological studies of Aconitum pharmaceutical resources

Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

Contact Info

Product

Resources

About