Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

Zhao, Lihong; Sun, Zhihui; Yang, Limin; Cui, Ranji; Yang, Wei; Li, Bingjin

doi:10.1111/1440-1681.13228

Cited by 40 publications

(24 citation statements)

References 87 publications

(211 reference statements)

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“…In addition to the purpose of pain control or digestion, there are reports that aconitine has been tried for the purpose of alleviating other neurological diseases such as depression, epilepsy, and dementia. The mechanism aimed to increase the expression of BDNF or to control the sensitivity to serotonin [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Aconitine Neurotoxicity According to Administration Methods

Chung

Lee

et al. 2021

JCM

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We evaluated the toxic effects of aconitine on the human nervous system and its associated factors, and the general clinical characteristics of patients who visited the emergency room due to aconitine intoxication between 2008 and 2017. We also analyzed the differences related to aconitine processing and administration methods (oral pill, boiled in water, and alcohol-soaked), and the clinical characteristics of consciousness deterioration and neurological symptoms. Of the 41 patients who visited the hospital due to aconitine intoxication, 23 (56.1%) were female, and most were older. Aconitine was mainly used for pain control (28 patients, 68.3%) and taken as oral pills (19 patients, 46%). The patients showed a single symptom or a combination of symptoms; neurological symptoms were the most common (21 patients). All patients who took aconitine after processing with alcohol showed neurological symptoms and a higher prevalence of consciousness deterioration. Neurological symptoms occurred most frequently in patients with aconitine intoxication. Although aconitine intoxication presents with various symptoms, its prognosis may vary with the processing method and prevalence of consciousness deterioration during the early stages. Therefore, the administration method and accompanying symptoms should be comprehensively investigated in patients who have taken aconitine to facilitate prompt and effective treatment and better prognoses.

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Section: Discussionmentioning

confidence: 99%

Aconitine Neurotoxicity According to Administration Methods

Chung

Lee

et al. 2021

JCM

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“…RIN also inhibits the Ca 2+ influx in the central nervous system. Aconitine is an important active ingredient in aconitum that acts directly on the sodium ion channel, which not only changes the voltage sensitivity and ion selectivity of a sodium ion channel but also reduces the hyperpolarization potential caused by Na + current activation as well as reduces the maximum inward current (Zhao et al, 2020). In addition, 3acetylaconitine has been reported to inhibit the excitation through mediation of sodium channels.…”

Section: Natural Medicines Improves Epilepsy By Regulating Ion Channelsmentioning

confidence: 99%

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

et al. 2021

Front. Pharmacol.

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Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is closely related to the neurotransmitter imbalance, synaptic recombination, and glial cell proliferation. In addition, epileptic seizures can lead to mitochondrial damage, oxidative stress, and the disorder of sugar degradation. Although the mechanism of epilepsy research has reached up to the genetic level, the presently available treatment and recovery records of epilepsy does not seem promising. Recently, natural medicines have attracted more researches owing to their low toxicity and side-effects as well as the excellent efficacy, especially in chronic diseases. In this study, the antiepileptic mechanism of the bioactive components of natural drugs was reviewed so as to provide a reference for the development of potential antiepileptic drugs. Based on the different treatment mechanisms of natural drugs considered in this review, it is possible to select drugs clinically. Improving the accuracy of medication and the cure rate is expected to compensate for the shortage of the conventional epilepsy treatment drugs.

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“…Three flavonoids were isolated from Viola odorata and tested in mice (TST and FST) to compare their antidepressant-like effects with those of the standard drug, fluoxetine. The compounds were identified as 5,7-dihydroxy-3,6-dimethoxyflavone (33), 5,7,4′-trihydroxy-3′,5′dimethoxyflavone (34), and 5,7,4′-trihydroxy-3′-methoxyflavone (35, Fig. 4S, Supplementary Information); all exhibited activity on 5-HT 1A , 5-HT 2A , and 5-HT 3 receptors but not on D 1 and D 2 receptors.…”

Section: Dosementioning

confidence: 99%

Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

Moragrega

Rı́os

2021

Planta Med

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Medicinal plants and their extracts are natural remedies with enormous potential for treating various diseases, including depression and anxiety. In the case of depression, hundreds of plants have traditionally been used in folk medicine for generations. Different plant extracts and natural products have been analyzed as potential antidepressant agents with validated models to test for antidepressant-like effects in animals, although other complementary studies have also been employed. Most of these studies focus on the possible mediators implicated in these potential effects, with dopamine, serotonin, and noradrenaline being the principal neurotransmitters implicated, both through interference with receptors and with their metabolism by monoamino oxidases, as well as through neuro-endocrine and neuroprotective effects. There are approximately 650 reports of antidepressant-like medicinal plants in PubMed; 155 of them have been compiled in this review, with a relevant group yielding positive results. Saffron and turmeric are the most relevant species studied in both preclinical and clinical studies; St. Johnʼs wort or kava have also been tested extensively. To the best of our knowledge, no review to date has provided a comprehensive understanding of the biomolecular mechanisms of action of these herbs or of whether their potential effects could have real benefits. The purpose of this narrative review is to provide an update regarding medicinal plants from the year 2000 to the present to examine the therapeutic potential of these antidepressant-like plants in order to contribute to the development of new therapeutic methods to alleviate the tremendous burden that depression causes worldwide.

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Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

Cited by 40 publications

References 87 publications

Aconitine Neurotoxicity According to Administration Methods

Aconitine Neurotoxicity According to Administration Methods

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies

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