Anal Human Papillomavirus Genotype Distribution in HIV-Infected Men Who Have Sex with Men by Geographical Origin, Age, and Cytological Status in a Spanish Cohort

Torres, Montserrat; González, Cristina; Romero, Jorge del; Viciana, Pompeyo; Ocampo, Antonio; Rodríguez-Fortúnez, Patricia; Masiá, Mar; Blanco, José Ramón; Portilla, Joaquín; Rodrı́guez, Carmen; Hernández-Novoa, Beatriz; Amo, Julia del; Ortiz, Marta

doi:10.1128/jcm.01405-13

Cited by 47 publications

(26 citation statements)

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“…This was similar to reports from North America (1,2,5) and the Spanish multicenter group CoRIS-HPV (85.6%) (26). Most of our patients (65.3%) had multiple HR-HPV infections, with a similar frequency to the CoRIS-HPV group (63.7%).…”

Section: Discussionsupporting

confidence: 90%

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

et al. 2017

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Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain. Rev Esp Enferm Dig 2017;109(4):242-249. DOI: 10.17235/reed.2017109(4):242-249. DOI: 10.17235/reed. .4274/2016 Received: 26-02-201626-02- Accepted: 22-12-2016 ABSTRACT Background and aims:Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain).Method: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors.Results: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma.Conclusions: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations.

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Section: Discussionsupporting

confidence: 90%

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

et al. 2017

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“…In the present study a very high prevalence of HPV infection was found in both, individuals with abnormal and normal anal cytology. This high prevalence had been also found in various studies developed in HIV-infected men [7, 8, 23]. Torres et al found a global HPV prevalence of 95.8% (95% CI, 94.6 to 96.7).…”

Section: Discussionsupporting

confidence: 52%

“…Recent studies have demonstrated that more than 90% of HIV-positive MSM were also infected with HPV [2, 7]. This particular group has a very high risk of developing ASIL and anal cancer [8].…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in anal intraepithelial lesions from HIV infected Cuban men

Limia

Soto

García

et al. 2017

Infect Agents Cancer

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BackgroundAn association between HPV infection and progression to anal squamous intraepithelial lesions (ASIL) has been established, specifically in high-risk populations such as HIV-infected men. In this population, anal cancer is one of the most common non-AIDS-defining malignancies.MethodsA cross-sectional study to detect anal lesions and HPV infection was performed. Anal mucosa samples were collected from 56 HIV-infected men from Cuba. The cytological diagnosis was done according to Bethesda 2001 System. HPV DNA detection was determined by qPCR for six high-risk HPV types and end point PCR for low-risk HPV types (6 and 11). The end point PCR with nucleotide sequencing technique was achieved to detect other genotypes of HPV not included in the qPCR in those samples negative for HPV- 6 and 11 or negative for the six genotypes identified in the qPCR.ResultsCytological diagnosis identified 53 of 56 (95%) men with abnormal anal cytology. Among those, 26% (14/53) had atypical squamous cells of undetermined significance (ASC-US), 4% (2/53) had atypical squamous cells of undetermined significance cannot exclude high-grade lesions (ASC-H), 64% (34/53) had low-grade squamous intraepithelial lesions (LSIL), and 6% (3/53) had high-grade squamous intraepithelial lesions (HSIL). HPV DNA was detected in 89% (50/56) of men and 79% had at least one of the high-risk HPV types. HPV- 16 was the most common genotype (52%), while HPV-18 was the most frequently detected genotype in men with HSIL. We found statistically significant differences in the HPV viral loads with respect to the cytology results (p = 0.0006) and that the practice of receptive anal sex was a risk factor for anal HPV infection (p = 0.032).ConclusionThis study shows a high prevalence of ASIL and high-risk HPV infections in the study group and is the first study showing the distribution of HPV genotypes in HIV infected Cuban men with abnormal anal cytology. This information may be of importance for local decision makers to improve prevention strategies, including the introduction of HPV vaccine in Cuba.

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“…Many epidemiological studies have been conducted to investigate anal HPV prevalence among HIV-infected MSM in several countries and regions. Anal HPV prevalence in HPV-infected MSM was 61.0% of 92 patients in the United States [3], 74.2% of 140 in Spain [4], 75.9% of 361 in Japan [5], 82.7% of 133 in Korea [6], 88.6% of 166 in Italy [7], 91.8% of 85 in South Africa [8], and 95.5% of 1439 in Spain [9]. The high prevalence of anal HPV infection observed in the present study is similar to that previously reported in other countries.…”

Section: Discussionmentioning

confidence: 97%

“…Conversely, HPV58 and 52, which are common type in Japanese women, were considerably prevalent in the anus of the Japanese MSM population. In addition to HPV6 and 16, HPV51 and 58 were also relatively frequent in South Africa [8], HPV11 and 61 in Italy [7], and HPV53 and 84 in Spain [9]. The distribution of HPV types is likely to slightly differ between different regions and populations.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus prevalence in the anus and urine among HIV-infected Japanese men who have sex with men

Yaegashi

Shigehara

Itoda³

et al. 2017

Journal of Infection and Chemotherapy

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Keywords:Human papillomavirus Human immunodeficiency virus Men who have sex with men Anal sample Urine a b s t r a c tBackground: The present study investigated human papillomavirus (HPV) prevalence in anal and urine samples, and evaluated cytological findings among human immunodeficiency virus (HIV)-infected Japanese men who have sex with men (MSM). Methods: A total of 148 patients were enrolled. Anal and urine samples were collected from each participant, and a HPV-DNA test and genotyping were performed using flow-through hybridization. In addition, anal cytology was evaluated based on Papanicolaou staining. Questionnaires regarding lifestyle habits and sexual behavior were obtained. Results:The b-globin gene was positive in 131 (88.5%) anal samples and 139 (94.0%) urine samples. Among the b-globin-positive samples, the HPV prevalence in anal and urine samples was 80.9% and 30.9%, respectively. High-risk HPV (HR-HPV) was detected in 57.3% of anal samples and 20.9% of urine samples. Among 122 adequate cytological samples, anal cytological abnormalities were observed in 99 cases (81.1%). Anal cytological tests revealed that atypical squamous cells of an undetermined significance (ASCUS) were detected in 57 (46.7%) patients, followed by low-grade squamous intraepithelial lesions (SIL) in 35 (28.7%), high-grade SIL in five (4.1%), and atypical squamous cells cannot exclude highgrade SIL (ASC-H) in two (1.6%), respectively. The nadir counts of CD4-positive T-lymphocyte less than 200 mL and anal HR-HPV infection were independent risk factors for anal cytological atypia over ASC-H. Conclusions:The present study demonstrated high HPV prevalence in the anus and urine, and showed a high incidence of anal cytological atypia associated with HR-HPV infections among HIV-infected MSM patients.

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Anal Human Papillomavirus Genotype Distribution in HIV-Infected Men Who Have Sex with Men by Geographical Origin, Age, and Cytological Status in a Spanish Cohort

Cited by 47 publications

References 27 publications

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

Human papillomavirus infection in anal intraepithelial lesions from HIV infected Cuban men

Human papillomavirus prevalence in the anus and urine among HIV-infected Japanese men who have sex with men

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