Anaesthetic potential of propofol for nile tilapia (Oreochromis niloticus): Effect of anaesthetic concentration and body weight

Obirikorang, Kwasi Adu; Asante-Tuoh, Diana Takyiwaa; Agbo, Nelson Winston; Amponsah, Andoh Kwaku; Skov, Peter Vilhelm

doi:10.1016/j.sciaf.2020.e00595

Cited by 3 publications

(8 citation statements)

References 40 publications

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“…Anesthetic induction occurred quickly, between 1 and 5 minutes, with no hyperactivity and stress reactions being observed. This reinforces the hypothesis that short induction times are desirable because they reduce the possibility of hypoxemia and acute stress responses (Obirikorang et al, 2020).…”

Section: Discussionsupporting

confidence: 85%

Surgical removal of periocular neoformation in Peixe -Kinguiu (Carassius Auratus) submitted to anesthesia with propofol in combination with morphine - case report

Rorig

Garcez

Baumgartner

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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Different anesthetic agents are commonly used during procedures performed in aquaculture to minimize stress and maximize fish welfare during handling. A Kinguio fish was treated with a history of a mass near the left eye. In the clinical evaluation, a pedunculated neoformation was found in the periocular region. The fish was submitted to anesthesia for surgical removal of the mass, which was later referred to histopathological evaluation, revealing myxoma. The anesthesia protocol used 1% propofol at a concentration of 5 mg/liter of water and morphine at a dose of 5 mg/kg, intramuscularly. Immediately after the end of the procedure, the fish was returned to the aquarium and its anesthetic recovery was observed. The objective of this report is to describe a surgical procedure in kinguio fish and to determine the efficacy of propofol associated with morphine in this species. As a result, complete immobilization of the fish was obtained with propofol, reaching the fourth stage of anesthesia and the administration of morphine suggested being able to provide effective and long-lasting analgesia. It is concluded that despite the positive results obtained, anesthesia in fish still needs to be extensively investigated to refine analgesia protocols during procedures that cause pain and stress.

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Section: Discussionsupporting

confidence: 85%

Surgical removal of periocular neoformation in Peixe -Kinguiu (Carassius Auratus) submitted to anesthesia with propofol in combination with morphine - case report

Rorig

Garcez

Baumgartner

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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“…Behavioral changes are of particular value for the welfare assessment of animals [ 60 ]. Propofol is a widely used anesthetic that targets the gamma-aminobutyric acid A (GABA A ) receptors in the fish brain following rapid absorption through the gills into the arterial blood circulation [ 28 , 61 , 62 ]. It has recently been tested as an anesthetic for Nile tilapia [ 28 ] without reported side effects in this species [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Propofol is a widely used anesthetic that targets the gamma-aminobutyric acid A (GABA A ) receptors in the fish brain following rapid absorption through the gills into the arterial blood circulation [ 28 , 61 , 62 ]. It has recently been tested as an anesthetic for Nile tilapia [ 28 ] without reported side effects in this species [ 24 ]. Yet, in the current study, the fish transport simulated under propofol showed a decreased frequency of swimming and bottom swimming but spent more time swimming than the MS-222 group and were less inactive (frequency and duration of inactivity).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the reduced hematocrit value observed was certainly not related to the pH changes. Nevertheless, a reduction of the hematocrit has previously been reported in Nile tilapia anaesthetized with propofol concomitant with a reduction in red blood cells and hemoglobin levels [ 28 ]. Still, similar and contradictory results have been reported in other fish species in which hemoglobin levels were both increased or decreased by propofol [ 73 , 74 ], warranting further clarification.…”

Section: Discussionmentioning

confidence: 99%

“…It is a short-acting, rapid recovery, and fast metabolized anesthetic agent with a lack of cumulative effects reported in Nile tilapia ( Oreochromis niloticus ) [ 24 ], the second most farmed fish worldwide [ 27 ]. In addition, although recent studies have characterized propofol induction and recovery in this species [ 28 , 29 ], no thorough research has been conducted so far using propofol for transport conditions of Nile tilapia, while it has been validated for the transport of other species [ 26 ]. Still, due to between- and within-species drug responses differences, anesthetics must be investigated on a species-by-species basis to assure its safe use [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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MS-222 and Propofol Sedation during and after the Simulated Transport of Nile tilapia (Oreochromis niloticus)

Félix

Correia

Sequeira

et al. 2021

Biology

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The use of anesthetics has been suggested as a strategy to hamper live fish transport-induced stress. Still, there is insufficient data available on the use of alternative anesthetics to MS-222. This study investigated the use of propofol to mitigate stress in Nile tilapia (Oreochromis niloticus, 143.8 ± 20.9 g and 20.4 ± 0.9 cm) during a 6 h simulated transport. Individuals (n = 7) were divided into three groups: control, 40 mg L−1 MS-222, and 0.8 mg L−1 propofol. A naïve group non-transported was also considered. During the 6 h transport and 24 h after, the response to external stimuli, opercular movements, water quality parameters, behavior, blood hematology and other physiological values, the histopathology of the gills, the quality of the fillet, and oxidative-stress changes in gills, muscle, brain, and liver were evaluated. Propofol increased swimming activity of fish but decreased opercular movements and responses to external stimuli, indicating oscillations of the sedation depth. Water pH and glucose levels increased, while hematocrit (HCT) and lactate decreased in propofol groups at 6 h. At this time-point, MS-222 also induced a decrease in the HCT and lactate levels while increasing cortisol levels. Despite these effects, the stress-related behaviors lessened with anesthetics compared to the control group. After the recovery period, physiological responses normalized in animals from both anesthetic groups, but the control still had high cortisol levels. Overall, propofol is a good alternative for the transportation of this species, showing efficient sedation without compromising health or fillet quality. However, further pharmacodynamics and pharmacokinetics knowledge is required to support its use in aquaculture settings.

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Evaluation of Immersion in Emulsified Isoflurane or Propofol as Part of a Two-Step Euthanasia Protocol in Marbled Crayfish (Procambarus Virginalis)

Heinz,

Wenninger

2024

Journal of Zoo and Wildlife Medicine

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Anaesthetic potential of propofol for nile tilapia (Oreochromis niloticus): Effect of anaesthetic concentration and body weight

Cited by 3 publications

References 40 publications

Surgical removal of periocular neoformation in Peixe -Kinguiu (Carassius Auratus) submitted to anesthesia with propofol in combination with morphine - case report

Surgical removal of periocular neoformation in Peixe -Kinguiu (Carassius Auratus) submitted to anesthesia with propofol in combination with morphine - case report

MS-222 and Propofol Sedation during and after the Simulated Transport of Nile tilapia (Oreochromis niloticus)

Evaluation of Immersion in Emulsified Isoflurane or Propofol as Part of a Two-Step Euthanasia Protocol in Marbled Crayfish (Procambarus Virginalis)

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