Anaesthetic efficacy of lidocaine/clonidine for inferior alveolar nerve block in patients with irreversible pulpitis

Abstract

For mandibular molars with irreversible pulpitis, addition of clonidine to lidocaine improved the success rate of IANB compared to a standard lidocaine/epinephrine solution.

Effect of clonidine on the efficacy of lignocaine local anesthesia in dentistry: A systematic review and meta‐analysis of randomized, controlled trials

“…Manual search yielded one more study that met the inclusion criteria. Full texts of the identified papers were read in entirety, and five studies were included for final review and quantitative analysis . The PRISMA flowchart, as per PRISMA guidelines, is presented in Figure .…”

“…The PRISMA flowchart, as per PRISMA guidelines, is presented in Figure . The characteristics of the included studies are provided in Table . The risk of bias of the included studies is presented in Figure .…”

“…This has been attributed to β1 and β2 adrenergic receptor action, which increases heart rate and vasodilation in muscles and internal organs . With this in mind, alternatives to adrenaline were sought, and clonidine has been trialed in various randomized, controlled trials . Clonidine is an α2 adrenergic agonist that stimulates α2 receptors, thereby decreasing peripheral vascular resistance.…”

Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta‐analysis

“…However, the literature is controversial when comparing the efficacy of both drugs in patients with symptomatic irreversible pulpitis (Cohen et al 1993, Maniglia-Ferreira et al 2009, Cunha et al 2011, Allegretti et al 2016Rodr ıguez-Wong et al 2016, Visconti et al 2016. There is an even greater uncertainty considering the limited scientific literature on the efficacy of mepivacaine compared to other drugs (Claffey et al 2004, Tortamano et al 2009, Sampaio et al 2012, Ashraf et al 2013, Aggarwal et al 2014, Kung et al 2015, Monteiro et al 2015, Parirokh et al 2015, Schellenberg et al 2015, Fowler et al 2016, Shadmehr et al 2017. The present systematic literature review aimed to compare the efficacy of mepivacaine and lidocaine for promoting pulpal anaesthesia and pain control during root canal treatment.…”

“…, Shadmehr et al . ). The present systematic literature review aimed to compare the efficacy of mepivacaine and lidocaine for promoting pulpal anaesthesia and pain control during root canal treatment.…”