BACKGROUNDSevere pain experienced by mother during the labor can cause fear and anxiety which can interfere with the overall labor process. Controlling pain during the labor process is important. Regiosacralis counterpressure pain management without altering the interleukin-6 (IL-6) level is expected to reduce the pain.OBJECTIVEThis study was aimed to investigate the effects of regiosacralis counterpressure on the pain and IL-6 levels during the first stage of labor among primigravid mothers.METHODA quasiexperiment method with pretest–posttest control group design was applied. Regiosacralis counter-pressure pain management was applied to all study participants who non-randomly recruited by consecutive sampling methods. A total of 52 primigravid mothers were selected and divided into both the intervention group (n = 26) and the control group (n = 26).RESULTThe statistical analysis of the intervention on the pain and IL-6 level showed significant different result between pretest and posttest in the intervention group (p < .001; M pretest pain = 8.96±.528; M posttest pain = 6.96±.774; M pretest IL-6 = 175.539±92.281; M posttest IL-6 = 170,764±70,026).CONCLUSIONRegiosacralis counterpressure treatment is effective to control and reduce pain level during the first stage labor.