Anaerobic Septicemia After Transrectal Prostatic Biopsy

Harris, LeRoy F.

doi:10.1001/archinte.1978.03630270039016

Cited by 17 publications

(6 citation statements)

References 15 publications

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“…Some reports in the late 1970s showed bacteremia by anaerobic bacteria after TRUSPB [6,7]. Others demonstrated that approximately 70% of patients [4,8,9] experienced transitory bacteremia and between 21% and 53% [4,10] showed significant bacteriuria during or immediately after the procedure.…”

Section: Discussionmentioning

confidence: 99%

Transrectal ultrasound-guided prostate biopsy: is antibiotic prophylaxis necessary?

et al. 2006

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The aim of this study was to assess infectious complications in transrectal ultrasound-guided prostate biopsy (TRUSPB), comparing two groups of patients: one group with antibiotic prophylaxis and the other without prophylaxis. A total of 1,018 TRUSPBs were performed from April 1996 to July 2003. No antibiotic prophylaxis was given in the first 614; the remaining 404 procedures were performed under antibiotic prophylaxis. Biopsy complications were assessed at outpatient urologist visits after the procedure in the 212 first biopsies and by telephone interview in the remaining 806. A total of 78 infectious complications were found. Major infectious complications (n=41) were septic shock (n=3), sepsis (n=3), Fournier gangrene (n=1), urinary tract infection (n=2), and fever requiring hospital admission (n=32). Minor infectious complications were fever that did not require admission (n=29), prostatitis (n=6), and epididymitis (n=2). Infectious complications occurred in 63 of 614 (10.3%) procedures without antibiotic prophylaxis and in 15 of 404 (3.7%) of those with antibiotic prophylaxis (P=0.0001). Of the 41 major infectious complications, 31 (75.6%) occurred in procedures without antibiotic prophylaxis (n=583) versus ten (24.4%) in those with prophylaxis (n=394) (P=0.0410). In conclusion, transrectal ultrasound-guided biopsy of the prostate has a statistically significant higher risk of infectious complications when performed without antibiotic prophylaxis.

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Section: Discussionmentioning

confidence: 99%

Transrectal ultrasound-guided prostate biopsy: is antibiotic prophylaxis necessary?

et al. 2006

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“…Despite being used by a third of hospitals in our survey, the evidence for the use of metronidazole appears to come from just two case studies in the 1970s describing life‐threatening anaerobic infection after TRUSgpb [16,17]. Recent RCTs have shown no or a very low percentage of metronidazole‐sensitive anaerobic growth [3,6], no RCTs have provided evidence for metronidazole, and it has no pharmacological evidence of action against the main septic organisms.…”

Section: Coveragementioning

confidence: 99%

Antibiotics for Transrectal Ultrasonography‐guided Prostate Biopsy: Are We Practising Evidence‐based Medicine?

2008

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“…There is also debate about which organisms play a major role in infection after biopsy; anaerobes [1,8,12] or coliforms [4,9] (Table 1). Anaerobic septicaemia has been reported to have serious and potentially fatal sequelae [8,12]. In one study [1], Bacteroides spp was the most common organism isolated from blood cultures after TNBP.…”

Section: The Spectrum Of Pathologymentioning

confidence: 99%

“…However, anaerobic infections are less common and the study populations in both studies were insufficient to assess this component. Given the reports of serious infections and fatal septicaemia [8,12] with anaerobic infection after biopsy it appears wise to broaden the prophylactic spectrum to include this group.…”

Section: The Case In Supportmentioning

confidence: 99%