Anaerobic infections of the female genital tract

Sweet, Richard L.

doi:10.1016/0002-9378(75)90736-x

Cited by 72 publications

(22 citation statements)

References 52 publications

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“…Success of medical therapy alone has ranged between 67-90%; but, approximately 25% of TOAs require surgical drainage 5 . Initial studies by Altemeier found anaerobic streptococci in 92% of TOA specimens 6 , and more recent investigations detected mixed aerobic and anaerobic flora in nearly all cases of TOA 4,7 . The recognition that pelvic abscesses are associated with anaerobic bacteria and are frequently polymicrobial led to improved antibiotic coverage including antibiotics like clindamycin and metronidazole that have good anaerobic activity 5 .…”

Section: Introductionmentioning

confidence: 94%

Etiology of Persistent Tubo‐Ovarian Abscess in Nairobi, Kenya

Cohen

Gravelle

Symekher

et al. 2002

Infectious Diseases in Obstetrics and Gynecology

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Objective To study the microbial etiology of tubo-ovarian abscess (TOA). Methods We recruited 11 women in Nairobi, Kenya who failed antibiotic therapy alone and required surgical drainage of a presumptive TOA. Pus from the nine abscesses and two pyosalpinges were collected and cultured for aerobic, facultative and anaerobic microorganisms. Results Eleven women suspected of having a TOA were hospitalized and treated for a median of 6 days (range 3-14 days) prior to surgical drainage of the abscess. Nine (82%) specimens were culture positive. Aerobes were present in all nine specimens. Seven of the nine positive cultures (78%) were polymicrobial and five of the polymicrobial cultures contained both anaerobes and aerobes. Anaerobic Gram-negative bacilli (Prevotella sp., Porphyromonas sp. and Bacteroides sp., Escherichia coli) and Streptococcus sp. (S. viridans and S. agalactiae) were the most common microorganisms isolated. Neisseria gonorrhoeae and Chlamydia trachomatis were not isolated by culture or detected by polymerase chain reaction. Conclusions In Kenya, persistent TOAs are associated with endogenous flora similar to that normally found in the gastrointestinal tract.

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Section: Introductionmentioning

confidence: 94%

Etiology of Persistent Tubo‐Ovarian Abscess in Nairobi, Kenya

Cohen

Gravelle

Symekher

et al. 2002

Infectious Diseases in Obstetrics and Gynecology

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“…There has been a lack of appreciation of the significant role anaerobes play in obstetric and gynecologic infections. Utilization of newer appropriate anaerobic culture techniques has shown the importance of these organisms as pathogens in severe infections of the genital tract [4]. Clinically, anaerobes have very high proportion in all infection cases of female genital tract and their infection rate reaches as high as 73.89% [5].…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that anaerobes were isolated in the secretions of patients with pelvic abscess, appendix abscess, non-venereal Bartholin gland abscess, postpartum endometritis, infection abortion and infection of vaginal residual after hysterectomy. Their positive rates were 80-90%, 63%, 66-70%, 70-93%, 81-100% and 76-80%, respectively [4,[6][7][8]. Streptococcus anaerobes and bacteroides fragilis are frequently isolated from puerperal infection and infectious abortion.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Antibacterial Activity of Antibiotics to Anaerobes of Female Genital Tract in Vitro

Zhan¹

2016

EJPM

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This study to investigate predominant anaerobic bacteria and their sensitivity spectrum to antibiotics in female patients with genital tract infections from the local and thus to provide scientific basis for the appropriate use of antibiotics. Anaerobic culture method was used to culture and isolate anaerobes in female patients with genital tract infections. Anaerobes were identified by using micro-biochemistry reacting technique and antibiotic-disc susceptibility test. Antibacterial activity of antibiotics to anaerobes was analyzed by means of Kirby-Bauer testing and broth micro-dilution method. The experiment results showed that 72 strains of obligate anaerobes were isolated from 103 samples, positive rate of 69.90%. The predominant anaerobic bacterial were Gram-negative non-spore bacteroides (28 strains, 38.89%) and anaerobic peptostreptococcus (18 strains, 25%). Sensitivity rate of anaerobic cocci, bacteroides and veillonella to metronidazole was 90.91%, 85.71% and 80% respectively. The drug resistance rates of the three isolated anaerobes were all higher than 60% to amikacin, erythromycin and clindamycin. Comparing the MIC 50 and MIC 90 values of metronidazole (MTZ), penicillin G (PCG) and lincomycin (LCM) on the isolated anaerobes, MTZ had the lowest MIC 50 and MIC 90 value. The study suggested that anaerobic infection has become a major pathogenic bacterium of infectious diseases in obstetrics and gynecology. Although MTZ has shown strong antibacterial activity in vitro, a few drug resistant strains appeared in the clinically isolated anaerobes and there is an upward trend of the MIC values of MTZ at different rates.

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“…The incidence of endometritis following cesarean delivery has ranged from 5 to 85%. Endometritis is polymicrobial [2][3][4] in nature; therefore, antibiotic coverage often requires multiple agents to achieve adequate coverage. In an attempt to simplify the therapy, some investigators s'6 have evaluated monotherapy with cephamycins.…”

Section: Introductionmentioning

confidence: 99%

Single‐Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment ofPostcesarean Endometritis

Chatwani

Martens²,

Grimes³

et al. 1995

Infectious Diseases in Obstetrics and Gynecology

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Objective: The purpose of this study was to compare the clinical efficacy and safety of cefmetazole given by IV push with that of parenterally administered cefoxitin for the treatment of endometritis following cesarean delivery.Methods: In a single-blind, multicenter, prospective, randomized study, 355 patients with endometritis after cesarean delivery were enrolled and received medication. Administered was either cefmetazole sodium, 2 g by IV push over I min q 8 h, or cefoxitin sodium, 2 g IV q 6 h in a 2:1 ratio.

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Anaerobic infections of the female genital tract

Cited by 72 publications

References 52 publications

Etiology of Persistent Tubo‐Ovarian Abscess in Nairobi, Kenya

Etiology of Persistent Tubo‐Ovarian Abscess in Nairobi, Kenya

Analysis of Antibacterial Activity of Antibiotics to Anaerobes of Female Genital Tract in Vitro

Single‐Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment ofPostcesarean Endometritis

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