Anaerobic Brain Abscess following Chronic Suppurative Otitis Media in a Child from Uganda

Cox, Kelly A; Al‐Rawahi, Ghada N.; Kollmann, Tobias R.

doi:10.1155/2009/407139

Cited by 16 publications

(12 citation statements)

References 15 publications

(15 reference statements)

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“…To the best of our knowledge, this is the first reported case of C. hastiforme causing sepsis in human beings. There are two previous reports of C. hastiforme causing eyelid gas gangrene [10] and brain abscess [11]. It has also been reported as colonizer in a fouryear-old male with severe combined immune deficiency [12].…”

Section: Discussionmentioning

confidence: 98%

Clostridium hastiformeSepsis in a Patient with Gastrointestinal Malignant Disease

SamantaPalash

MollaIrida

LenoxTheodore

2016

Surgical Infections Case Reports

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Background: Different Clostridial organisms, commensal in gut flora, can cause blood stream infections, especially in underlying malignant disease. Here, we are presenting first case report of Clostridium hastiforme sepsis in a patient with rectal malignant disease. Methods: Case report and review of pertinent English-language literature. Result: A 49-y-old female with known rectal malignant disease was admitted for sepsis with sudden onset sharp rectal pain, fever, leukocytosis, and lactic acidosis. The patient was undergoing palliative chemotherapy. Computed tomography (CT) revealed large rectal carcinoma with central necrosis and distant metastasis. She was started empirically with intravenous vancomycin and piperacillin-tazobactam. Blood culture grew gramvariable rods only in anaerobic bottles, which was subsequently identified as C. hastiforme. Antimicrobials were changed to metronidazole. The patient improved clinically and was discharged subsequently. Conclusions: The report emphasizes the importance of rare Clostridial organisms to cause sepsis in patients with underlying gastrointestinal malignant disease. Patients with this condition are usually gravely ill and the infection can be easily missed if anaerobic culture is not routinely ordered.

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Section: Discussionmentioning

confidence: 98%

Clostridium hastiformeSepsis in a Patient with Gastrointestinal Malignant Disease

SamantaPalash

MollaIrida

LenoxTheodore

2016

Surgical Infections Case Reports

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“…C hastiforme has not been described in association with brain abscessation in the veterinary literature; however, it has been associated with a brain abscess following a chronic OM in a child from Uganda. 19 Brainstem abscesses associated with severe clinical signs are rarely reported in the veterinary literature and the prognosis is usually guarded to poor. 1,11,12 A mortality rate of 100% was reported by Klopp et al in two cases of brainstem abscessation; 1 intracranial empyema appears to have a more favourable prognosis with a mortality rate of 50% in cases managed with medical treatment alone.…”

Section: Discussionmentioning

confidence: 99%

CT-guided drainage of a brainstem abscess in a cat as an emergency treatment procedure

Bersan

Maddox

Walmsley

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 3-year-old male neutered domestic shorthair cat was presented with a 1-week progressive and rapidly deteriorating history of lethargy and abnormal behaviour. Neurolocalisation indicated multifocal intracranial lesions (right oculomotor nerve, brainstem [obtundation, non-ambulatory tetraparesis, vestibular dysfunction and intermittent decerebrate rigidity] and possibly the thalamus [left-sided pleurothotonus]), or more likely a single brainstem lesion with mass effect. MRI of the brain demonstrated a brainstem abscess causing severe dorsal displacement particularly affecting the pons and the medulla oblongata causing cerebellar vermis herniation through the foramen magnum. CT-guided free-hand technique drainage of the brain abscess was performed and broad spectrum antibiotics were started based on sensitivity results. The cat recovered uneventfully from anaesthesia displaying marked improvement immediately after the procedure. Antibiotics were continued for 8 months; repeat imaging prior to withdrawal found complete resolution of the brainstem abscess. Relevance and novel information Free-hand CT-guided drainage of a brainstem abscess is not without risk; however, in this case it led to significant clinical improvement and stabilisation likely owing to reduced intracranial pressure. It also provided a diagnostic sample that allowed successful medical treatment planning and outcome. To our knowledge, this is the first report describing the successful management of a brainstem abscess by CT-guided drainage in the veterinary literature. It suggests that stereotactic drainage followed by medical therapy can be considered a successful therapeutic alternative to brain surgery or medical treatment alone, providing an emergency treatment in cases of acute brainstem dysfunction.

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“…hastiforme is a rare cause of human infection. A review of the literature only reveals a few case reports with highly variable infection sites, including brain abscess,8 eyelid gas gangrene,9 pseudarthrosis,10 blood10–12 and colonisation in a 4-year-old boy with combined immune deficiency 13…”

Section: Discussionmentioning

confidence: 99%

Clostridium hastiformebacteraemia secondary to pyometra in a 64-year-old woman

2017

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The Gram-negative, rod-shaped, anaerobe bacteria Tissierella praeacuta was first described in 1908 by Tissier. However, during the past decade, Clostridium hastiforme has been recognised as a later synonym of T. praeacuta. C. hastiforme/T. praeacuta has only rarely been described in previous literature as a cause of human infection. We present here a case report of C. hastiforme/T. praeacuta bacteraemia secondary to pyometra in a 64-year-old woman with a history of multiple sclerosis and an intrauterine device inserted three decades earlier. C. hastiforme/T. praeacuta was isolated from blood as well as pus from the site of infection. The patient was cured with a combination of drainage and antibiotic therapy.

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Anaerobic Brain Abscess following Chronic Suppurative Otitis Media in a Child from Uganda

Cited by 16 publications

References 15 publications

Clostridium hastiformeSepsis in a Patient with Gastrointestinal Malignant Disease

Clostridium hastiformeSepsis in a Patient with Gastrointestinal Malignant Disease

CT-guided drainage of a brainstem abscess in a cat as an emergency treatment procedure

Clostridium hastiformebacteraemia secondary to pyometra in a 64-year-old woman

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