Anaerobic Bacterial Flora of Intra-abdominal Infections and their Antimicrobial Susceptibility Pattern in Kuwait

Panigrahi, D; Rotimi, V.O.; Dhar, Rita; Td, Chugh; Dhar, P; Ghali, Adel; Saad, Adel; Sanyal, Sudip; Varghese, T.L.

doi:10.1006/anae.2001.0404

Cited by 5 publications

(8 citation statements)

References 16 publications

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“…In comparison with other results, the MIC 90 value of imipenem, which we determined as 1 g/ml for our Prevotella strains, could be evaluated as a high MIC value [6,8,21,23,34] . This situation could be explained with the frequent use of imipenem in the empirical treatment of anaerobic infections in our country.…”

Section: Discussionmentioning

confidence: 99%

“…In an evaluation of 83 intra-abdominal abscesses, Panigrahi et al [21] reported the presence of P. intermedia at a rate of 10.5%, P. melaninogenica at 4.6%, P. bivia at 2.4% and Prevotella corporis, P. denticola, Prevotella oralis and Porphyromonas species at a rate of 2% . Of the 68 intra-abdominal abscesses in our present study, P. loescheii and P. asaccharolytica strains were the predominant bacteria isolated at a rate of 90.9 and 84.8%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…An incidence of 26-100% in black-pigmented Prevotella, including P. intermedia, P. melaninogenica and P. loescheii , and 37.5-77.1% in nonpigmented Prevotella has been reported [4,6,8,20,21,23,26,27] . In our study, 34.7% of black-pigmented Prevotella and 37.5% of nonpigmented Prevotella produced ␤ -lactamase.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies reported that Prevotella and Porphyromonas species play an important role in the pathogenicity of anaerobic infections [2,3,5,[20][21][22][23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

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Antimicrobial Resistance and β-Lactamase Production of Clinical Isolates of Prevotella and Porphyromonas Species

Bahar

Torun²,

Demırci³

et al. 2005

Chemotherapy

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Background: This study determined the β-lactamase production and the antimicrobial resistance of 72 Prevotella species and 48 Porphyromonas species isolated from different clinical specimens. Methods: All strains were identified using API 32 ID. The β-lactamase production was determined by nitrocefin disks. E test strips of benzylpenicillin, ampicillin + sulbactam, cefoxitin, clindamycin, metronidazole and imipenem were tested for each strain. Results: Nineteen Prevotella melaninogenica, 18 Prevotella intermedia, 16 Prevotella denticola, 11 Prevotella loescheii and 8 Prevotella bivia strains were identified. Four wereclindamycin resistant. The highest β-lactamase production was found at a rate of 68.4% in P. melaninogenica species. Additionally, 33 Porphyromonas asaccharolytica and 15 Porphyromonas gingivalis strains were identified. None of them produced β-lactamase. Conclusion: In view of the emerging antibiotic resistance among anaerobes, the current local susceptibility profile of our Prevotella and Porphyromonas species will establish the basis for additional surveys tracing significant changes in the antimicrobial resistance of our clinical isolates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Many studies reported that Prevotella and Porphyromonas species play an important role in the pathogenicity of anaerobic infections [2,3,5,[20][21][22][23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial Resistance and β-Lactamase Production of Clinical Isolates of Prevotella and Porphyromonas Species

Bahar

Torun²,

Demırci³

et al. 2005

Chemotherapy

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“…The species most often isolated from faecal flora are Bacteroides vulgatus, Bacteroides thetaiotaomicron, Bacteroides distasonis and, to a lesser extent, Bacteroides fragilis and Bacteroides ovatus [1,2]. These organisms cause opportunistic infections in a wide range of sites such as intra-abdominal infections, perirectal abscess, blood and soft tissue infections [3][4][5]. Over the last three decades, metronidazole (MTZ) has remained the main therapy of choice and it has been used extensively in prophylaxis and therapy of infections due to Bacteroides spp., because Bacteroides have been predictably sensitive, and because strains of this genus are often resistant to the main clinically relevant antibiotics, such as ß-lactam antibiotics, tetracycline or macrolides-lincosamides-strepto-gramins [6].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Nitroimidazole Resistance in Metronidazole-Resistant Bacteroides Species Isolated from Hospital Patients in Kuwait

Jamal

Rotimi²,

Brazier³

et al. 2004

Med Princ Pract

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Objectives: The aim of this study was to screen for infections caused by metronidazole (MTZ)-resistant Bacteroides spp., and to characterize the genes that encode the MTZ resistance. Materials and Methods: A total of 7 MTZ-resistant Bacteroides spp. were isolated from 5 patients with MTZ-resistant infections. These organisms were investigated for carriage of genes that encode MTZ resistance. The presence of these genes was investigated by PCR and the PCR products were subjected to PCR-RFLP analysis. Results: The strains were MTZ-resistant with minimum inhibitory concentrations of >32 µg/ml. The presence of nim genes was indicated by PCR in all 7 strains. PCR-RFLP analysis of the nim gene products demonstrated two of the five reported resistance genes, nimA–nimE. These two resistance genes were nimE in 5 of the 7 isolates and nimA in 2 strains. Conclusion: MTZ-resistant Bacteroides spp. have been isolated from patients in Kuwait. Nim genes, specifically nimE and nimA, mediate the drug resistance in these isolates. The methods used in detecting these genes are rapid, accurate and relatively inexpensive and could be adopted easily to help in monitoring emergence of MTZ resistance determinants in Kuwait.

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Antibiotic susceptibility of clinically relevant anaerobes in Estonia from 1999 to 2001

Lõivukene¹,

Naaber

2003

Anaerobe

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Anaerobic Bacterial Flora of Intra-abdominal Infections and their Antimicrobial Susceptibility Pattern in Kuwait

Cited by 5 publications

References 16 publications

Antimicrobial Resistance and β-Lactamase Production of Clinical Isolates of <i>Prevotella </i>and <i>Porphyromonas</i> Species

Antimicrobial Resistance and β-Lactamase Production of Clinical Isolates of <i>Prevotella </i>and <i>Porphyromonas</i> Species

Molecular Characterization of Nitroimidazole Resistance in Metronidazole-Resistant <i>Bacteroides</i> Species Isolated from Hospital Patients in Kuwait

Antibiotic susceptibility of clinically relevant anaerobes in Estonia from 1999 to 2001

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