Antimicrobial Resistance and β-Lactamase Production of Clinical Isolates of &lt;i&gt;Prevotella &lt;/i&gt;and &lt;i&gt;Porphyromonas&lt;/i&gt; Species

Bahar, Hrisi; Torun, Müzeyyen Mamal; Demırci, Mehmet; Kocazeybek, Bekir

doi:10.1159/000084017

Cited by 28 publications

(22 citation statements)

References 55 publications

(55 reference statements)

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“…The results of the present study showed that three antibiotics including amoxicillin/clavulanic acid, doxycycline and azithromycin had 100% activities against P. gingivalis which can provide alternative antibiotics to treat the patients whenever indicated. The fact that 12 % of the bacteria were resistant or intermediate resistant to amoxicillin but 100 % were sensitive to amoxicillin/clavulanic acid, indicates that resistance of P. gingivalis to β-lactam antibiotics are due to β-lactamase production (25,26). Low values of MIC 50 and MIC 90 of the three effective antibiotics were also noticed in this study, which could suggest that systemic antibiotic therapy may deliver adequate drug inside the infected teeth (27,28).…”

Section: Discussionsupporting

confidence: 49%

Antibacterial susceptibility patterns of Porphyromonas gingivalis isolated from chronic Periodontitis patients

Japoni¹,

Vasin²,

Noushadi³

et al. 2011

Med Oral

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Objectives: To test the antimicrobial sensitivity of Porphyromonas gingivalis to a panel of eight orally administrable antibiotics in chronic periodontal diseases and to evaluate factors associated with periodontitis in adult patients. Study Design: A total of fifty strains of P. gingivalis were isolated from one hundred and twenty adult patients with chronic perio-dontitis. Identification of bacteria was carried out by anaerobic culture and biochemical tests. Selected colonies of P. gingivalis were used to evaluate the antibacterial activities of penicillin, metronidazole, amoxicillin, amoxicillin/clavulanic acid, clindamycin, doxy-cycline, ciprofloxacin and azithromycin. Results: Most of the patients were female, age ranging between 40 to 50 years. Majority of the patients frequently had scaling and depths of periodontal pockets in infected teeth were 5-8 mm and most of them had hemorrhage during sampling. Susceptibility testing revealed a sensitivity of 100% of P. gingivalis to azithromycin, doxycycline and amoxicillin/clavulanic acid but lower susceptibilities were found for the rest of antibiotic agents evaluated. Conclusions: Frequent scaling in women aged between 40-50 years had positive correlation with chronic periodontitis. The application of antibiotics in conjuction with mechanical debridation, may reflect in the level of resistance of P. gingivalis in patients with chronic periodontal infections. This could suggest periodical antibiotic susceptibility testing is necessary to determine the efficacy of antimicrobial agents if the perfect curing of chronic periodontal diseases after mechanical debridation is meant. Further clinical studies are required to confirm the in vitro results. The only limitation in this study was identification of bacteria to species rather than subspecies level.

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Section: Discussionsupporting

confidence: 49%

Antibacterial susceptibility patterns of Porphyromonas gingivalis isolated from chronic Periodontitis patients

Japoni¹,

Vasin²,

Noushadi³

et al. 2011

Med Oral

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“…This concentration is higher than the in vitro MIC 90 values (i.e. the minimum inhibitory concentration of an antimicrobial agent that inhibits the growth of 90% of susceptible isolates) shown in the in vitro susceptibility studies of oral bacteria referred to in our study [50][51][52][53][54][55]. Thus, 2 g/mL theoretically falls outside the normal distribution of MICs for each of the species under the current study.…”

Section: Discussionmentioning

confidence: 69%

Prevalence of subgingival bacteria resistant to aminopenicillins and metronidazole in dental patients from Yemen and Norway

Al‐Haroni

Skaug

Al-Hebshi

2006

International Journal of Antimicrobial Agents

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“…The treatment of Prevotella spp. varies from β-lactamase to a combination of β-lactam-β-lactamase inhibitors, and carbapenems for more severe infections (7). The present study reports a brain abscess after chronic otitis media infection due to P. denticola, which is a rare cause of brain abscess.…”

Section: Introductionmentioning

confidence: 73%

Mastoiditis, Brain Abscess and Sinus Thrombosis As Complications of Chronic Otitis Media: A Case Report

Maçin

İnkaya

Doğan

et al. 2016

Jundishapur J Microbiol

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Introduction: Brain abscess is a rare life-threatening focal intracerebral infection. The etiology of brain abscess depends on trauma, surgical intervention, and infection type. In this report, we present a case with brain abscess caused by Prevotella denticola after chronic otitis media infection. Case Presentation: A 27-year-old male patient presented a history of yellowish green ear drainage coloring his pillow for 10 years. One month before admission, he began to suffer from increased headache. He was first admitted to another hospital and treated with ceftriaxone for otitis media. He was referred to our hospital when a brain abscess was detected in cerebral magnetic resonance imaging (MRI). Meropenem and vancomycin treatment was stated empirically because of failure of the previous antibiotic therapy. The abscess was drained through a burr hole on the second day of admission. The aerobic culture of the pus resulted negative; however, black pigmented colonies were detected on anaerobic culture plates. The organism was identified as P. denticola via molecular typing targeting the 16S RNA gene. The postoperative period was complicated by left temporal hematoma that required surgical intervention; left transverse and sigmoid sinuses thrombosis were treated with enoxaparine. Because of the critical condition of the patient, de-escalation was not considered, and the patient received meropenem plus vancomycin for 6 weeks until discharge with complete cure. Conclusions: In conclusion, in spite of usually benign features, chronic otitis media may lead to serious complications such as brain abscess. Every effort should be made for microbiological diagnosis of the causative pathogen(s) for appropriate antibiotic treatment.

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Antimicrobial Resistance and β-Lactamase Production of Clinical Isolates of <i>Prevotella </i>and <i>Porphyromonas</i> Species

Cited by 28 publications

References 55 publications

Antibacterial susceptibility patterns of Porphyromonas gingivalis isolated from chronic Periodontitis patients

Antibacterial susceptibility patterns of Porphyromonas gingivalis isolated from chronic Periodontitis patients

Prevalence of subgingival bacteria resistant to aminopenicillins and metronidazole in dental patients from Yemen and Norway

Mastoiditis, Brain Abscess and Sinus Thrombosis As Complications of Chronic Otitis Media: A Case Report

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