Anaemia Associated with Trauma and Sepsis

Toxic Reactions Due to Intravenous Iron

“…I feel, however, that again this is more in keeping with an anaphylactic reaction. Vaughan (1948) suggests that the anaemia of trauma and sepsis is dependent on a disturbance of haemoglobin synthesis, especially the globin element, this being, in turn, part of a wider disturbance of protein metabolism dependent on the action of breakdown products liberated from injured tissues or by the need of injured tissues for special amino-acids. In long-standing pulmonary tuberculosis, disturbance of protein metabolism occurs, as has been mentioned above.…”

Protein Requirements of Infants: 2. Marasmus

“…Marriott (1920) and Utheim (1920) have found that the blood volume and the concentration of protein and of haemoglobin are often low in marasmic infants. Infection, if present, contributes to the production of low levels by depressing haemoglobin formation (Davidson and Fullerton, 1938;Vaughan, 1948) and plasma regeneration. Changes in the haemoglobin and serum protein levels cannot be used as a guide to the degree of depletion or to assess recovery in marasmic infants, since the normal range for both serum protein and haemoglobin kvels is wide in infancy, and they are often affected by factors other than protein depletion, such as infection and changes in the blood volume.…”

The Effect of Cobalt and Iron Salts on the Anaemia of Prematurity

“…It has been suggested by Wintrobe, Grinstein, Dubash, Humphreys, Ashenbrucker and Worth (1947) that cobalt may be needed in the synthesis of haemoglobin in the anaemia of sepsis, and Vaughan (1948) referred to this in a paper on the anaemia of sepsis and trauma, and suggested cobalt as a possible treatment of anaemias resulting from infection. It was because of the similarity between the anaemia of sepsis and that of prematurity that we decided to try the effect of cobalt in premature infants.…”