Toxic Reactions Due to Intravenous Iron

The treatment of iron-deficiency anaemia by iron-dextran infusion, with special reference to the effect on blood-grouping, coagulation, sedimentation and haemolysis

“…Earlier intravenous preparations such as colloidal ferric hydroxide and colloidal ferric oxide proved to be too toxic (Goethsch, Moore & Minnich, 1946) and the first practical form of intravenous therapy was a saccharated iron oxide compound (Nissim, 1947) but even with this substance a significant number of severe toxic reactions occurred (Barrit & Swain, 1953;Librach, 1953;Nissim, 1954;Ross, 1957;Bare & Sullivan, 1960).…”

The Treatment of Iron Deficiency Anaemia by Iron‐Dextran Infusion: A Radio‐Isotope Study

“…The first practical form of parenteral therapy was a preparation of saccharated iron oxide for intravenous use (Nissim, 1947), earlier intravenous preparations such as colloidal ferric hydroxide and colloidal ferric oxide having proved too toxic (Goetsch, Moore and Minnich, 1946). Even with Nissim's preparation a significant number of toxic reactions occurred (Barrit and Swain, 1953;Librach, 1953 ;Nissim, 1954;Ross, 1957). An iron-dextran complex for intramuscular use was introduced by Fletcher and London in 1954 and has been extensively used.…”