Anabolic resistance assessed by oral stable isotope ingestion following bed rest in young and older adult volunteers: Relationships with changes in muscle mass

Abstract

Bed rest-induced AR is much greater in the older than in younger adults. We have developed a new, simple, non-invasive method for the assessment of AR. The results indicate that this metabolic abnormality is a key mechanism for sarcopenia of aging and inactivity.

MRI‐Derived Biomarkers Related to Sarcopenia: A Systematic Review

“…Of 67 records identified through search query and two identified through other sources, 45 were excluded from title and abstract, while the remaining 24 were downloaded for a deeper assessment. Finally, a total of 18 articles matched the topic at issue …”

“…Functional anisotropy and T 2 relaxation time were also proposed to investigate muscle quality. Indeed, increased fractional anisotropy values in the bilateral quadriceps muscles were observed by Melville et al in a patient with sarcopenia, while increased T 2 values were found and in frail/prefrail subjects affected by sarcopenia …”

“…This fact can be explained by the higher signal‐to‐noise ratio of these scanners compared with 1.5T scanners. On the other hand, MSF was inferior to 3T used to acquire T 1 ‐ and T 2 ‐weighted images for the purpose of muscle quantification …”

“…As expected, several studies aimed at evaluating sex and age differences in muscle composition in healthy adults . However, it is difficult to establish a unique definition of "healthy subject.…”

“…Finally, a total of 18 articles matched the topic at issue. [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Study design was prospective in 14/18 (78%) articles and retrospective in 4/18 [40][41][42]45 (22%), and articles were published between 2012 and 2018. The number of published articles per year is presented in Fig.…”