An updated weight of evidence approach to the aquatic hazard assessment of Bisphenol A and the derivation a new predicted no effect concentration (Pnec) using a non-parametric methodology

Wright-Walters, Maxine; Volz, Conrad D.; Talbott, Evelyn O.; Davis, Devra Lee

doi:10.1016/j.scitotenv.2010.07.092

Cited by 83 publications

(44 citation statements)

References 66 publications

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“…The PNECs used were 0.12, 0.82, 0.06, 0.11, 0.11, 0.006, 0.002, 0.0001, and 0.06 μg/L for 4-t-OP, 4-NP, BPA, NP1EO, NP2EO, E1, E2, EE2, and E3, respectively (Caldwell et al 2012;Fenner et al 2002;Lin et al 2005;Loos et al 2007;Wright-Walters et al 2011). According to the literatures Fenner et al 2002), if RQ was greater than one, an unacceptable risk to the environment would be expected.…”

Section: Environmental Implicationsmentioning

confidence: 99%

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China

Huang

Sun

et al. 2014

Environ Sci Pollut Res

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The occurrence and behavior of endocrine disrupting chemicals (EDCs) in sewage treatment plants (STPs), especially estrogens and phenols, have been closely concerned in previous studies. However, the systematical researches about progestogens and androgens were scarce in STPs adopting different treatment technologies. This work investigated the occurrence, removal, and fate of one progestogen, three androgens, four estrogens, and six phenols in six STPs around Dianchi Lake in China, where the influents, effluents of primary treatment, secondary treatment, and advanced treatment, as well as excess sludge samples, were analyzed. All of the above EDCs were detected out in influents of the six STPs. Bisphenol A, nonylphenol-mono-ethoxylate, and nonylphenol-diethoxylate were the dominant EDCs detected in those influent samples with the concentrations that varied from 637.6 to 1,684.0 ng/L, 633.8 to 1,540.0 ng/L, and 648.7 to 2,246.0 ng/L, respectively; E1 and dihydrotestosterone were the major steroids with the mean concentration of 126.8 and 277.4 ng/L. For effluents and sludges, phenols showed higher concentration (366.8-1,233.0 ng/L and 1,478.1-6,948.9 ng/g dry weight (dw)) and detection rate (100 %). The total removal rates were more than 80 % for most compounds in wastewater treatment processes, and high removal efficiency (86-100 %) was found for androgens and progestogens compared with estrogens (75-92 %) and phenols (62-85 %). The secondary treatment processes play significant roles on degrading EDCs, whereas the primary sedimentation has little effects. The treatment capacity of anoxic-anaerobic-anoxic membrane bioreactor and anaerobic/anoxic/oxic technologies was superior to the conventional oxidation ditch in the degradation of EDCs. The advanced treatment process, two units of filter (D-type or V-type), and ultraviolet disinfection were adopted and presented effective to remove these compounds. According to fate analysis, it was obvious that biological degradation was the main pathway on the removal of EDCs in STPs compared with adsorption. Risk quotients were calculated to assess ecological risks of those EDCs. Risk quotients of 54 and 61 % were more than 1 in effluents and sludges, respectively, showing potential hazard of effluents and sludges to the environment.

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Section: Environmental Implicationsmentioning

confidence: 99%

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China

Huang

Sun

et al. 2014

Environ Sci Pollut Res

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“…BPA is widely used to produce polycarbonate plastics and epoxy resins used in different products of daily lives including electronic equipment, water pipes, sports safety equipment, medical devices, tableware, reusable bottles, and food storage containers (Huang et al 2012;Ikezuki et al 2002). Global demand for BPA is expected to increase by 6-10 %/y (Wright-Walters et al 2011). Recently, the European Union prohibited the use of BPA in plastic infant feeding bottles in a landmark move to protect the health of infants and the general population (Asimakopoulos et al 2012).…”

mentioning

confidence: 99%

Association of Serum Bisphenol-A Concentration and Male Reproductive Function Among Exposed Workers

Zhuang

Wang

et al. 2014

Arch Environ Contam Toxicol

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Bisphenol-A (BPA) can alter endocrine function in animals, yet the relationship between human exposure to BPA and male reproductive function is not well understood. We collected serum samples from 281 male workers exposed to BPA and 278 controls. Serum BPA concentrations were analyzed by gas chromatography-mass spectrometry after derivatization. The serum levels of sex hormone-binding globulin (SHBG) and total testosterone (TT) were detected by radioimmunoassay and levels of inhibin B (INB) and androstenedione (AD) by enzyme-linked immunosorbent assay. We examined the association of BPA exposure and male sex hormone levels by multivariable linear regression. Both serum BPA concentrations and detection rates were greater in males exposed than those not exposed to BPA, but the two groups did not differ in levels of SHBG, TT, INB, or AD. Compared with exposure for ≤5 years, exposure for >5 years was associated with increased serum BPA and SHBG 1evels and decreased AD levels. Compared with undetectable BPA and BPA ≤ 18.75 ng/mL, BPA level >18.75 ng/mL was associated with low AD and high SHBG levels (P < 0.05). On adjusted multivariable regression, increased serum BPA level was associated with decreased mean serum AD level (0.18 ng/mL; 95% confidence interval CI -0.22 to -0.13) and increased mean serum SHBG level (2.79 nmol/L; 95% CI 2.11-3.46). Serum BPA levels were increased after occupational exposure. BPA exposure was negatively associated with serum AD level but positively associated with serum SHBG level.

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“…The Directive 2008/105/EC (Directive, 2008b) considered this compound as ''possible future priority substance'' while it was not prioritized by Directive 2013/39/EU (Directive, 2013). Toxicological effects of BPA have been demonstrated in human and animals (Venisse et al, 2014) and, furthermore, risk assessment models demonstrated that aquatic systems may not be protected from adverse effects at the current predicted no-effect concentration (PNEC) established value (100 lg L À1 ) (Wright-Walters et al, 2011). Consequently, and in our opinion, more studies are needed to take an adequate decision.…”

Section: Introductionmentioning

confidence: 96%

Occurrence of endocrine disrupting compounds in five estuaries of the northwest coast of Spain: Ecological and human health impact

et al. 2015

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An updated weight of evidence approach to the aquatic hazard assessment of Bisphenol A and the derivation a new predicted no effect concentration (Pnec) using a non-parametric methodology

Cited by 83 publications

References 66 publications

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China

Association of Serum Bisphenol-A Concentration and Male Reproductive Function Among Exposed Workers

Occurrence of endocrine disrupting compounds in five estuaries of the northwest coast of Spain: Ecological and human health impact

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