An update on the role of miR-379 in human disorders

Ghafouri‐Fard, Soudeh; Shaterabadi, Donya; Abak, Afete; Shoorei, Hamed; Bahroudi, Zahra; Taheri, Mohammad; Mousavinejad, Seyed Ali

doi:10.1016/j.biopha.2021.111553

Cited by 11 publications

(9 citation statements)

References 43 publications

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“…The primary transcripts produced by RNA polymerase II have 5’-cap and 3’-polyadenylated tail. Then, Drosha ribonuclease III enzyme cleaves this transcript to make the stem-loop precursor miRNA with an estimated size of 70 nucleotides ( 2 ). Finally, this transcript is processed by the Dicer ribonuclease to make the mature miRNA which can be combined into the RNA-induced silencing complex.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

et al. 2022

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miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer’s and Parkinson’s diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.

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Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

et al. 2022

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“…Likewise, multiple studies have examined the roles of a subset of miRNAs located at the miR-379/miR-656 cluster (in subcluster B) in breast cancer; these were shown to be associated with tumor suppressing roles together with impacts on EMT ( 69 ). In laryngeal and nasopharyngeal cells, wherein miR-379 expression is reduced, overexpression of miR-379 reduced migratory capacity and hindered EMT ( 8 ). In osteosarcoma cells, miR-379 levels are reduced along with promoting metastasis ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…Although the role of VHL and other relevant genes at 3p are well established in ccRCC ( 1 ), the miRNA cluster present at 14q has been less well studied. However, there are reports of its deregulated expression and potential contributions to the pathogenesis of other cancer types ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Deregulated expression of the 14q32 miRNA cluster in clear cell renal cancer cells

et al. 2023

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Clear cell renal cell carcinomas (ccRCC) are characterized by arm-wide chromosomal alterations. Loss at 14q is associated with disease aggressiveness in ccRCC, which responds poorly to chemotherapeutics. The 14q locus contains one of the largest miRNA clusters in the human genome; however, little is known about the contribution of these miRNAs to ccRCC pathogenesis. In this regard, we investigated the expression pattern of selected miRNAs at the 14q32 locus in TCGA kidney tumors and in ccRCC cell lines. We demonstrated that the miRNA cluster is downregulated in ccRCC (and cell lines) as well as in papillary kidney tumors relative to normal kidney tissues (and primary renal proximal tubule epithelial (RPTEC) cells). We demonstrated that agents modulating expression of DNMT1 (e.g., 5-Aza-deoxycytidine) could modulate 14q32 miRNA expression in ccRCC cell lines. Lysophosphatidic acid (LPA, a lysophospholipid mediator elevated in ccRCC) not only increased labile iron content but also modulated expression of a 14q32 miRNA. Through an overexpression approach targeting a subset of 14q32 miRNAs (specifically at subcluster A: miR-431-5p, miR-432-5p, miR-127-3p, and miR-433-3p) in 769-P cells, we uncovered changes in cellular viability and claudin-1, a tight junction marker. A global proteomic approach was implemented using these miRNA overexpressing cell lines which uncovered ATXN2 as a highly downregulated target. Collectively, these findings support a contribution of miRNAs at 14q32 in ccRCC pathogenesis.

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“…The process of miRNA synthesis contains multiple steps with the final step being incorporation of either the 5p or 3p strands of the mature miRNA duplex into a complex, namely miRNA-induced silencing complex (miRISC). Notably, shuttling of this complex inside the cell has an essential role in the extent of miRNA-mediated modulation of gene expression ( O'Brien et al, 2018 ; Ghafouri-Fard et al, 2021b ; Ghafouri-Fard et al, 2021c ; Ghafouri-Fard et al, 2021d ). miRNAs regulate gene expression in a dynamic manner which results in buffering of expression levels to reach a stable state ( O'Brien et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

A review on the importance of miRNA-135 in human diseases

et al. 2022

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MicroRNA-135 (miR-135) is a microRNA which is involved in the pathoetiology of several neoplastic and non-neoplastic conditions. Both tumor suppressor and oncogenic roles have been reported for this miRNA. Studies in prostate, renal, gallbladder and nasopharyngeal cancers as well as glioma have shown down-regulation of miR-135 in cancerous tissues compared with controls. These studies have also shown the impact of miR-135 down-regulation on enhancement of cell proliferation and aggressive behavior. Meanwhile, miR-135 has been shown to be up-regulated in bladder, oral, colorectal and liver cancers. Studies in breast, gastric, lung and pancreatic cancers as well as head and neck squamous cell carcinoma have reported dual roles for miR-135. Dysregulation of miR-135 has also been noted in various non-neoplastic conditions such as Alzheimer’s disease, atherosclerosis, depression, diabetes, Parkinson, pulmonary arterial hypertension, nephrotic syndrome, endometriosis, epilepsy and allergic conditions. In the current review, we summarize the role of miR-135 in the carcinogenesis as well as development of other disorders.

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An update on the role of miR-379 in human disorders

Cited by 11 publications

References 43 publications

A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

Deregulated expression of the 14q32 miRNA cluster in clear cell renal cancer cells

A review on the importance of miRNA-135 in human diseases

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