A review on the importance of miRNA-135 in human diseases

Kadkhoda, Sepideh; Eslami, Solat; Hussen, Bashdar Mahmud; Ghafouri‐Fard, Soudeh

doi:10.3389/fgene.2022.973585

Cited by 20 publications

(14 citation statements)

References 120 publications

(54 reference statements)

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“…In a recent publication in E. sea bass, the authors identified higher levels of circulating miR-499 in plasma differentiating males when comparted to differentiating females (Houdelet et al, 2023). Another example of a male-like miRNAs in fish gonads is the miR-135, which is a biomedical marker in humans due to its involvement in many cancer and disorders like Alzheimer disease (Kadkhoda et al, 2022; Zheng et al, 2021). Similar to our data, in tilapia, miR-135 presented sexual dimorphism towards males as it was upregulated in testes together with miR-33a, miR-132 and miR-212 (Herkenhoff et al, 2018; Xiao et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Identification of sex-biased miRNA markers informative of heat-past events

van Gelderen,

Montfort,

Álvarez-Dios

et al. 2024

Preprint

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Elevated temperatures during early developmental stages play a pivotal role in the fate of the final sexual phenotype of fish populations, particularly towards male-skewed sex ratios . This is the case with European sea bass (Dicentrarchus labrax), one of the most important European species in the aquaculture industry. To unveil informative markers of the past thermal events, we investigated changes in the miRNome within the gonads of this species. Consequently, we exposed European sea bass to elevated temperatures during early development and conducted miRNA-sequencing analysis in the ovaries and testes one year post-heat treatment. The examination of miRNA expression levels identified three and twelve miRNAs in ovaries and testes, respectively, reflecting past thermal events. To assess the evolutionary conservation of these identified miRNAs in gonads, we cross-referenced our data with miRNome public information from ovaries and testes in nine additional fish species. This analysis uncovered 43 potential sex-biased markers present in at least five studied species along the evolutionary timeline. For instance, miR-155, miR-429, and miR-140 were female-skewed while miR-184, miR-499, and miR-135 were male-skewed. In addition, among these markers, eight conserved sex-skewed miRNAs proved informative regarding past thermal events in both the ovaries (e.g., miR-192-5p and miR-143-3p) and testes (miR-129-5p, miR-2187a-3p, miR-724-5p, miR-143-3p, miR-194a-5p and miR-223-3p). Notably, miR-223-3p and miR-194a-5p were conserved female-skewed, but showed upregulation in males exposed to high temperature. These miRNAs could serve as markers of heat-induced masculinization of genetic female-prone fish. The current research broadens the inventory of sex-specific miRNAs along evolution in fish and, elucidates thermosensitive miRNAs in the gonads. These findings hold promise as potential tools for predicting historical environmental events associated with masculinization due to high-temperature treatments in cultured species but also perhaps for natural populations exposed to a climate change scenario.

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Section: Discussionmentioning

confidence: 99%

Identification of sex-biased miRNA markers informative of heat-past events

van Gelderen,

Montfort,

Álvarez-Dios

et al. 2024

Preprint

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“…Although this is among the first studies to report this finding, two other recent studies have found expression of miR-135 may be associated with partial differentiation in DPSC, which may explain why this is found among the slower-growing and potentially partially differentiated DPSC isolates (Ghahfarrokhi et al, 2020;Li et al, 2015). Interestingly, most other studies of miR-135 have demonstrated associations with specific types cancer-including digestive system cancers, which may also suggest that some tissue-specific differentiation may influence the expression of this microRNA that is restricted to specific types of cells and tissues in very specific locations (Kadkhoda et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Expression of Exosome-Derived MicroRNAs miR-21 and miR-135 are Differentially Regulated Among Dental Pulp Stem Cells

Hunsaker¹,

Richards²,

Fuller³

et al. 2023

Current Research in Medicine

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Dental Pulp Stem Cells (DPSCs) are a type of mesenchymal stem cell that has the potential to differentiate into various types of cells and tissue. Previous research has demonstrated that DPSCs can be easily accessed and isolated from both permanent and deciduous teeth, such as wisdom teeth or third molars, although there is less information available about the mechanisms and factors that regulate the growth and proliferative phenotypes and responses of DPSCs. Recent studies have revealed that a type of non-coding RNA known as microRNA can modulate these characteristics among many types of stem cells, although much is still unknown about how DPSC phenotypes may be regulated by microRNAs. Due to this lack of knowledge, the primary objective of this study was to evaluate microRNA expression and determine any correlations with DPSC phenotypes, such as proliferation or growth. Six DPSC isolates were retrieved from an existing repository and cultured using an existing approved protocol. Exosomes and extracellular vesicles were extracted from each DPSC isolate, which ranged in size from 50 to 250 nm. Exosome isolation was confirmed using Western blots for CD63 and Bradford protein assays. In addition, RNA was extracted, cDNA was synthesized, and qPCR was performed, which revealed that all DPSC isolates expressed miR-124, miR-133, and miR-224. However, differential expression of miR-21 among rapid and intermediate doubling time (rDT, iDT) isolates was observed, with expression of miR-135 found only among the intermediate and slow (iDT, sDT) DPSC isolates. This study provides some of the first evidence of associations between miRNA expression and specific DPSC growth phenotypes. Further studies will be needed to confirm these results and determine the mechanisms associated with the expression of miR-21 among rapidly growing DPSCs and miR-135 expression among more slowly growing DPSCs.

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“… 125 miR-135 Targets AKT and Wnt signaling pathways, and APC, FOXO1, FOXN1, RECK, some matrix metalloproteinases gene expression. 126 miR-144 Modulates the Src/AKT/ERK, Notch, JAK2/STAT3, EGFR, and PTEN/PI3K/AKT signaling pathways. 127 miR-153 Reduces PTEN expression.…”

Section: Are Mirnas Involved In the Pathogenesis Of Diabetes Mellitus...mentioning

confidence: 99%

“… 125 hsa-miR-135 Increased 66 Reduced in prostate, renal, gallbladder, and nasopharyngeal cancers, as well as in glioma, impacting the enhancement of cell proliferation and aggressive behavior. 126 Increased in bladder, oral, colorectal, and liver cancers. 126 Dual role in in breast, gastric, lung, and pancreatic cancers, as well as in head and neck squamous cell carcinomas.…”

Section: Are Mirnas Involved In the Pathogenesis Of Diabetes Mellitus...mentioning

confidence: 99%