An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery

Stanicki, Dimitri; Vangijzegem, Thomas; Ternad, Indiana; Laurent, Sophie

doi:10.1080/17425247.2022.2047020

Cited by 44 publications

(16 citation statements)

References 110 publications

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“…Among these routes, coprecipitation and thermal decomposition are the most widely used ones, especially for the preparation of nanometric scale (<20 nm) iron oxides. Other methods, such as micro-emulsion, sol–gel and polyol synthesis, and hydrothermal synthesis, with varying degrees of effectiveness, have also been developed [ 23 ].…”

Section: Fundamental Characteristics Of Magnetic Nanoparticlesmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

et al. 2023

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Despite significant advances in cancer therapy over the years, its complex pathological process still represents a major health challenge when seeking effective treatment and improved healthcare. With the advent of nanotechnologies, nanomedicine-based cancer therapy has been widely explored as a promising technology able to handle the requirements of the clinical sector. Superparamagnetic iron oxide nanoparticles (SPION) have been at the forefront of nanotechnology development since the mid-1990s, thanks to their former role as contrast agents for magnetic resonance imaging. Though their use as MRI probes has been discontinued due to an unfavorable cost/benefit ratio, several innovative applications as therapeutic tools have prompted a renewal of interest. The unique characteristics of SPION, i.e., their magnetic properties enabling specific response when submitted to high frequency (magnetic hyperthermia) or low frequency (magneto-mechanical therapy) alternating magnetic field, and their ability to generate reactive oxygen species (either intrinsically or when activated using various stimuli), make them particularly adapted for cancer therapy. This review provides a comprehensive description of the fundamental aspects of SPION formulation and highlights various recent approaches regarding in vivo applications in the field of cancer therapy.

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Section: Fundamental Characteristics Of Magnetic Nanoparticlesmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

et al. 2023

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“…Examples of common metal oxide-based nanoparticles are iron oxide (Fe 2 O 3 ), zinc oxide (ZnO), magnetite (Fe 3 O 4 ), silicon dioxide (SiO 2 ), aluminum oxide (Al 2 O 3 ), cerium oxide (CeO 2 ), titanium oxide (TiO 2 ), and many more [ 170 , 171 , 172 ]. As such, magnetic iron oxide nanoparticles (IONPs) have been used for tumour-targeted gene delivery [ 173 ], owing to their propitious properties, such as ease of chemical functionalization, high biocompatibility, low toxicity, direct synthesis methods, and superior magnetic responsiveness [ 174 , 175 , 176 , 177 ].…”

Section: Nanocomposites Ideamentioning

confidence: 99%

Micro and Nano Interdigitated Electrode Array (IDEA)-Based MEMS/NEMS as Electrochemical Transducers: A Review

et al. 2022

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Micro and nano interdigitated electrode array (µ/n-IDEA) configurations are prominent working electrodes in the fabrication of electrochemical sensors/biosensors, as their design benefits sensor achievement. This paper reviews µ/n-IDEA as working electrodes in four-electrode electrochemical sensors in terms of two-dimensional (2D) planar IDEA and three-dimensional (3D) IDEA configurations using carbon or metal as the starting materials. In this regard, the enhancement of IDEAs-based biosensors focuses on controlling the width and gap measurements between the adjacent fingers and increases the IDEA’s height. Several distinctive methods used to expand the surface area of 3D IDEAs, such as a unique 3D IDEA design, integration of mesh, microchannel, vertically aligned carbon nanotubes (VACNT), and nanoparticles, are demonstrated and discussed. More notably, the conventional four-electrode system, consisting of reference and counter electrodes will be compared to the highly novel two-electrode system that adopts IDEA’s shape. Compared to the 2D planar IDEA, the expansion of the surface area in 3D IDEAs demonstrated significant changes in the performance of electrochemical sensors. Furthermore, the challenges faced by current IDEAs-based electrochemical biosensors and their potential solutions for future directions are presented herein.

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“…These results appear particularly promising as these agents are already commonly used in the biomedical field [ 21 ]. One has to remember that IONPs (more specifically maghemite and magnetite) have been widely used as contrast enhancers for clinical magnetic resonance imaging (MRI), as a result of their biocompatibility and remarkable (super)paramagnetic properties [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles’ Radiosensitizing Properties

et al. 2023

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Among the plethora of nanosystems used in the field of theranostics, iron oxide nanoparticles (IONPs) occupy a central place because of their biocompatibility and magnetic properties. In this study, we highlight the radiosensitizing effect of two IONPs formulations (namely 7 nm carboxylated IONPs and PEG5000-IONPs) on A549 lung carcinoma cells when exposed to 225 kV X-rays after 6 h, 24 h and 48 h incubation. The hypothesis that nanoparticles exhibit their radiosensitizing effect by weakening cells through the inhibition of detoxification enzymes was evidenced by thioredoxin reductase activity monitoring. In particular, a good correlation between the amplification effect at 2 Gy and the residual activity of thioredoxin reductase was observed, which is consistent with previous observations made for gold nanoparticles (NPs). This emphasizes that NP-induced radiosensitization does not result solely from physical phenomena but also results from biological events.

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An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery

Cited by 44 publications

References 110 publications

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Micro and Nano Interdigitated Electrode Array (IDEA)-Based MEMS/NEMS as Electrochemical Transducers: A Review

Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles’ Radiosensitizing Properties

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