Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles’ Radiosensitizing Properties

Ternad, Indiana; Penninckx, Sébastien; Lecomte, Valentin; Vangijzegem, Thomas; Conrard, Louise; Lucas, Stéphane; Heuskin, Anne-Catherine; Michiels, Carine; Müller, Robert N.; Stanicki, Dimitri; Laurent, Sophie

doi:10.3390/nano13010201

Cited by 7 publications

(3 citation statements)

References 60 publications

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“…Overall, the effect on cell death of both types of irradiation is enhanced when IONP DOX compound is priorly added to the cells. It is known that iron oxide nanoparticles in presence of photon or particle radiation are capable to generate highly cyto- and genotoxic reactive oxygen species through the Fenton reaction and Haber–Weiss cycle 24 . In addition, the chemotherapeutic drug doxorubicin induces cytotoxicity through the generation of oxidative stress but also by DNA intercalation and inhibition of topoisomerase II 25 .…”

Section: Resultsmentioning

confidence: 99%

In vitro hyperspectral biomarkers of human chondrosarcoma cells in nanoparticle-mediated radiosensitization using carbon ions

Tudor,

Popescu,

Negoita

et al. 2023

Sci Rep

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New therapeutic approaches are needed for the management of the highly chemo- and radioresistant chondrosarcoma (CHS). In this work, we used polyethylene glycol-encapsulated iron oxide nanoparticles for the intracellular delivery of the chemotherapeutic doxorubicin (IONPDOX) to augment the cytotoxic effects of carbon ions in comparison to photon radiation therapy. The in vitro biological effects were investigated in SW1353 chondrosarcoma cells focusing on the following parameters: cell survival using clonogenic test, detection of micronuclei (MN) by cytokinesis blocked micronucleus assay and morphology together with spectral fingerprints of nuclei using enhanced dark-field microscopy (EDFM) assembled with a hyperspectral imaging (HI) module. The combination of IONPDOX with ion carbon or photon irradiation increased the lethal effects of irradiation alone in correlation with the induction of MN. Alterations in the hyperspectral images and spectral profiles of nuclei reflected the CHS cell biological modifications following the treatments, highlighting possible new spectroscopic markers of cancer therapy effects. These outcomes showed that the proposed combined treatment is promising in improving CHS radiotherapy.

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Section: Resultsmentioning

confidence: 99%

In vitro hyperspectral biomarkers of human chondrosarcoma cells in nanoparticle-mediated radiosensitization using carbon ions

Tudor,

Popescu,

Negoita

et al. 2023

Sci Rep

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“…IONPs are able to facilitate the combination of imaging with therapy, called theranostics, allowing for more precise drug delivery. 91,92 IONPs can serve as therapeutic agents via magnetic hyperthermia in an alternating magnetic field. The local increase in heat can be used to induce cancer cell death, as well as the triggered release of the loaded drug.…”

Section: Inorganic Npsmentioning

confidence: 99%

Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Shen,

Gwak,

Han

2024

Analyst

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“…The presence of superparamagnetic iron oxide nanoparticles (SPIO) may inhibit enzymes from the thioredoxin reductase family, preventing the regeneration of intracellular antioxidants and affecting the management of oxidative stress and the content of reactive oxygen species (ROS) [ 15 , 16 ]. ROS are metabolic byproducts generated in eukaryotic cells during aerobic respiration.…”

Section: Introductionmentioning

confidence: 99%

A Moexitecan Magnetic Liposomal Strategy for Ferroptosis-Enhanced Chemotherapy

et al. 2023

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Moexitecan (Mex) is a novel camptothecin derivative that retains the potent antitumor properties of camptothecin drugs and has improved hydrophilicity to enhance biocompatibility in vitro. However, single-drug therapy still has limitations. In this study, magnetic liposomes loaded with both moexitecan and superparamagnetic iron oxide nanoparticles (SPIO) have been fabricated by a film hydration and filtration method, which is abbreviated as Mex@MLipo. By using liposomes as drug carriers, Mex can be delivered specifically to the target site, resulting in improved therapeutic efficacy and reduced toxicity. Morphology characterization results show that Mex@MLipo has a mean diameter of 180–200 nm with a round morphology. The loading efficiencies of Mex and SPIO are 65.86% and 76.86%, respectively. Cell toxicity, in vitro cell uptake, and in vivo fluorescence imaging experiments showed that Mex@MLipo was the most effective in killing HT-29 cells compared with HepG-2 and PC-3 cells, due to its ability to combine chemotherapy and induce ferroptosis, resulting in a strong anti-tumor effect. Thus, this study developed an innovative nanoscale drug delivery system that paves the way for clinical applications of moexitecan.

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Advances in the Mechanistic Understanding of Iron Oxide Nanoparticles’ Radiosensitizing Properties

Cited by 7 publications

References 60 publications

In vitro hyperspectral biomarkers of human chondrosarcoma cells in nanoparticle-mediated radiosensitization using carbon ions

In vitro hyperspectral biomarkers of human chondrosarcoma cells in nanoparticle-mediated radiosensitization using carbon ions

Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

A Moexitecan Magnetic Liposomal Strategy for Ferroptosis-Enhanced Chemotherapy

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