An Update on Pharmacological Relevance and Chemical Synthesis of Natural Products and Derivatives with Anti SARS‐CoV‐2 Activity

Shagufta,; Ahmad, Irshad

doi:10.1002/slct.202103301

Cited by 11 publications

(4 citation statements)

References 207 publications

(345 reference statements)

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“…Considering the mechanism of COVID-19 invasion, the S spike pro, 3CL pro, P pro, RdRp, and non-structural protein 15 (NSP15) of SARS-COV-2, ACE2, and FURIN receptors of host cells can serve as drug targets (Saied et al, 2021). Previous reviews have reported that natural products of flavonoids, polyphenols, and alkaloids with complex structures may be more efficient against SARS-CoV-2 (Chapman & Andurkar, 2022;Shagufta & Ahmad, 2021). However, with the rapid mutation of the virus and the enhancement of other invasion pathways such as FURIN, GRP78, CD147, NRP1, and AXL, single structure molecular drugs that target only one protein site may not work well.…”

Section: Advantages Of Natural Active Products In the Treatment Of Co...mentioning

confidence: 99%

Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials

Zhao

Deng

Bai

et al. 2022

Phytotherapy Research

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The corona virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus type 2 (SARS‐COV‐2) poses a severe threat to human health and still spreads globally. Due to the high mutation ratio and breakthrough infection rate of the virus, vaccines and anti‐COVID‐19 drugs require continual improvements. Drug screening research has shown that some natural active products can target the critical proteins of SARS‐CoV‐2, including 3CLpro, ACE2, FURIN, and RdRp, which could produce great inhibitory effects on SARS‐COV‐2. In addition, some natural products have displayed activities of immunomodulation, antiinflammatory, and antihepatic failure in COVID‐19 clinical trials, which may relate to their non‐monomeric structures. However, further evaluation and high‐quality assessments, including safety verification tests, drug interaction tests, and clinical trials, are needed to substantiate natural products' multi‐target and multi‐pathway effects on COVID‐19. Here, we review the literature on several promising active natural products that may act as vaccine immune enhancers or provide targeted anti‐COVID‐19 drugs. The structures, mechanisms of action, and research progress of these natural products are analyzed, to hopefully provide effective ideas for the development of targeted drugs that possess better structure, potency, and safety.

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Section: Advantages Of Natural Active Products In the Treatment Of Co...mentioning

confidence: 99%

Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials

Zhao

Deng

Bai

et al. 2022

Phytotherapy Research

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“…Medicinal plant species are reported to play a major role in drug discovery and have become essential sources with pharmacological potential for the development of safe and potent drugs [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Antwi-Adjei

Obese

Adakudugu

et al. 2023

The Scientific World Journal

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Plant species have been used traditionally to treat numerous inflammatory disorders because of their known medicinal properties. This study aimed to assess the anti-inflammatory effect of aqueous ethanolic leaf extract of Persicaria lanigera using acute inflammatory models. The safety profile of the Persicaria lanigera extract was assessed using an acute toxicity model. The anti-inflammatory effect of the Persicaria lanigera leaf extract (100–600 mg·kg−1, p.o.) was studied in carrageenan-induced paw oedema, zymosan-induced knee joint arthritis, and histamine-induced paw oedema in Sprague–Dawley rats (n = 5). It was observed that the Persicaria lanigera leaf extract administered prophylactically significantly inhibited paw oedema from 99.01 ± 12.59 to 59.10 ± 4.94%, 56.08 ± 3.65%, and 48.62 ± 3.27% at 100 mg·kg−1, 300 mg·kg−1, and 600 mg·kg−1, while the standard drug, aspirin, showed 41.84 ± 9.25% in carrageenan-induced paw oedema, respectively. Furthermore, the extract decreased knee joint inflammation significantly from 62.43 ± 5.73% to 32.07 ± 2.98% and 24.33 ± 8.58% at 300 mg·kg−1 and 600 mg·kg−1 in zymosan-induced knee joint inflammation, respectively. In the histamine-induced paw oedema model, the extract significantly inhibited oedema to 61.53 ± 9.17%, 54.21 ± 9.38%, and 54.22 ± 9.37% at the same doses. Aqueous ethanolic leaf extract of Persicaria lanigera is safe and attenuates inflammation in acute inflammation models.

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“…More importantly, according to the study, baicalein can commonly induce cancer cell apoptosis without impacting the growth of normal cells, making it a perspective antitumor drug [ 4 , 5 ]. In addition, baicalein was identified as a promising antiviral drug for SARS-CoV-2, which causes COVID-19 infection [ 6 ]. Therefore, there is a great market demand for baicalein in pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Heterologous Biosynthesis of Health-Promoting Baicalein in Lycopersicon esculentum

et al. 2022

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Baicalein is a valuable flavonoid isolated from the medicinal plant Scutellaria baicalensis Georgi, which exhibits intensive biological activities, such as anticancer and antiviral activities. However, its production is limited in the root with low yield. In this study, In-Fusion and 2A peptide linker were developed to assemble SbCLL-7, SbCHI, SbCHS-2, SbFNSII-2 and SbCYP82D1.1 genes driven by the AtPD7, CaMV 35S and AtUBQ10 promoters with HSP, E9 and NOS terminators, and were used to engineer baicalein biosynthesis in transgenic tomato plants. The genetically modified tomato plants with this construct synthesized baicalein, ranging from 150 ng/g to 558 ng/g FW (fresh weight). Baicalein-fortified tomatoes have the potential to be health-promoting fresh vegetables and provide an alternative source of baicalein production, with great prospects for market application.

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An Update on Pharmacological Relevance and Chemical Synthesis of Natural Products and Derivatives with Anti SARS‐CoV‐2 Activity

Cited by 11 publications

References 207 publications

Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials

Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials

Modulating Effects of the Hydroethanolic Leaf Extract of Persicaria lanigera R. Br. Soják (Polygonaceae) against Acute Inflammation

Heterologous Biosynthesis of Health-Promoting Baicalein in Lycopersicon esculentum

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