An update on oral human papillomavirus infection

Abstract

Human papillomavirus (HPV) constitutes the majority of newly acquired sexually transmitted infections (STIs) in United States as per the centers for disease control factsheet 2013. Genital HPV is the most common STI with incidence of about 5.5 million world-wide, nearly 75% of sexually active men and women have been exposed to HPV at some point in their lives. Oral Sexual behavior is an important contributor to infection of HPV in the oral mucosa especially in cases known to practice high risk behavior and initiating the same at an early age. HPV infection of the oral mucosa currents is believed to affect 1-50% of the general population, depending on the method used for diagnosis. The immune system clears most HPV naturally within 2 years (about 90%), but the ones that persist can cause serious diseases. HPV is an essential carcinogen being implicated increasingly in association with cancers occurring at numerous sites in the body. Though there does not occur any specific treatment for the HPV infection, the diseases it causes are treatable such as genital warts, cervical and other cancers.

Le condylome acuminé isolé de la cavité buccale : à propos d’un cas clinique

“…Les condylomes acuminés sont des masses charnues associées aux HPV dont il existe plusieurs soustypes. L'HPV 6 et 11 sont généralement détectés par les mé-thodes d'immuno-histochimie et par hybridation avec des taux de positivité de 75 à 85 % [4]. En 1901, Heidingsfield a rapporté le cas de végétations véné-riennes de la langue chez une « puella publica » de 24 ans et chez laquelle l'origine suspectée était le « coït illegitimus » (les relations sexuelles bucco-génitales).…”

“…Heidingsfield a détaillé l'étude histologique des condylomes de la langue et de la lèvre de la patiente et a conclu que le condylome acuminé de la lèvre concordait avec le condylome acuminé de la localisation génitale non seulement sur le plan clinique mais aussi histologique [5]. Actuellement, il est admis que la voie oro-génitale est la principale voie de transmission [1,4]. Le patient ici présenté ne rapporte pas d'antécédent de rapport sexuel oro-génital, ce qui incite à appuyer l'hypothèse de la présence d'éven-tuel autre mode de transmission.…”

The role of human papillomaviruses in cancer progression

“…[151] The transmission of upper respiratory tract infections may be passed on by sexual contact and from mother to child during child birth canal. [4,152] Although many therapies have applied for RRP patients, such as surgical, treatment with antivirals and chemotherapeutic drugs; there is limited success with mostly side effects. [153] Therefore like all the other cancers, early detection and vaccines can play a crucial role in RRP.…”

Infecção do Papilomavírus Humano no fluído oral em homens infectados pelo HIV: prevalência da infecção e sua relação com os fatores de risco

“…Existe uma forte associação entre o comportamento sexual e o risco de infecção pelo HPV (72). Porém outros fatores como a idade, sexo e raça também veem sendo considerados como fatores potenciais (73).…”

“…Bharti et al (2013), sugeriu em seu estudo, que a infeção oral pelo HPV está primariamente associada com a prática sexual, especialmente a prática de sexo orogenital e que essa prática de risco, incluindo o número de parceiros e início precoce da vida sexual, contribui para o desenvolvimento da patogênese do HPV (39).…”