An update on nanoparticle-based contrast agents in medical imaging

Naseri, Neda; Ajorlou, Elham; Asghari, Fatemeh; Pilehvar-Soltanahmadi, Younes

doi:10.1080/21691401.2017.1379014

Cited by 70 publications

(28 citation statements)

References 148 publications

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“…Due to the rapid removal of the iodine developer, the effective time window of blood pool imaging is seriously limited, and a high-contrast image is difficult to obtain. Furthermore, the rapid clearance of a large dose of drugs may have potential side effects in the kidney [8,9].…”

Section: Introductionmentioning

confidence: 99%

Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging

Gao¹,

Kang

Lei³

et al. 2020

Nanoscale Res Lett

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In recent years, contrast agents have been widely used in imaging technology to improve quality. Nanoparticles have better in vivo detection capability than conventional molecular scale contrast agents. In this study, a new type of Au nanocages@PEG nanoparticles (AuNC@PEGs) with a strong X-ray absorption coefficient was synthesized as a contrast agent for computed tomography (CT) scan imaging. Results showed that AuNC@PEGs had good aqueous dispensation, low cytotoxicity, and strong X-ray absorption ability. Furthermore, in vivo studies have shown that the synthesized AuNC@PEGs have an evident contrast enhancement, long circulation time in the blood, and negligible toxicity in vivo. Therefore, the synthesized functionalized AuNC@PEGs in this study have great potential for clinical application in CT scan imaging.

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Section: Introductionmentioning

confidence: 99%

Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging

Gao¹,

Kang

Lei³

et al. 2020

Nanoscale Res Lett

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“…As the Raman imaging technique develops and its sensitivity increases, it is anticipated that imaging of nanocarrier placement in living systems in real time will be possible in the future. Nanoparticles are used in contrast agents due to their biocompatibility, high X-ray absorption coefficient and the ability to target a specific pathological tissue [63,64]. In addition, the nanoparticle contrast agent administered during the study improves the quality and resolution of the image, which allows earlier detection of lesions in the body.…”

Section: Diagnostic Imagingmentioning

confidence: 99%

Analysis of the Exposure of Organisms to the Action of Nanomaterials

et al. 2020

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The rapid development of the production of materials containing metal nanoparticles and metal oxides is a potential risk to the environment. The degree of exposure of organisms to nanoparticles increases from year to year, and its effects are not fully known. This is due to the fact that the range of nanoparticle interactions on cells, tissues and the environment requires careful analysis. It is necessary to develop methods for testing the properties of nanomaterials and the mechanisms of their impact on individual cells as well as on entire organisms. The particular need to raise public awareness of the main sources of exposure to nanoparticles should also be highlighted. This paper presents the main sources and possible routes of exposure to metal nanoparticles and metal oxides. Key elements of research on the impact of nanoparticles on organisms, that is, in vitro tests, in vivo tests and methods of detection of nanoparticles in organisms, are presented.

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“…More speci cally, nanosciences have been exploited in regions like drug delivery targeting cancer cell and other deadly ailments [5], water puri cations [6], electronics [7], imaging contrast agents [8] and catalysis [9][10][11][12]. We are particularly interested in nanocatalysis as the corresponding materials are having unique criteria like extremely small dimension, high surface to volume ratio, exceptional shape dependant properties, uniformity in particle size distribution, truly heterogeneous nature and reusable with almost constant e ciency [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Efficient biogenesis of Au nanoparticles using extract of Mentha pulegium flower: Evaluation of catalytic reduction of nitroarenes and anti-human colon cancer properties in the in vitro condition

Bovandi

Shahriari

Zangeneh

2020

Preprint

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Background With regards to applicative, facile, green chemical research, a bio-inspired approach is being reported for the synthesis of Au nanoparticles by using Mentha pulegium flower extract. Methods The phytochemical immobilized Au NPs were characterized by advanced physicochemical techniques like Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), and X-ray Diffraction (XRD) study. Thereafter, catalytic performance of those biomolecule functionalized Au NPs was investigated in the efficient reduction of nitroarenes over a range of substrates. To survey the anti-human colon cancer effects of gold nanoparticles, MTT assay was used on the common colon cancer cell lines i.e., colorectal adenocarcinoma (HT-29), colorectal carcinoma (HCT 116), ileocecal colorectal adenocarcinoma (HCT-8 [HRT-18]), and Burkitt's lymphoma (Ramos.2G6.4C10). Results The conversion was achieved in short reaction time with good to excellent yields in association with outstanding turnover frequency (TOF). In addition, the nanocomposite catalyst was easily recovered and recycled for 12 successive times without noticeable decrease in catalytic activity. Gold nanoparticles had high anti-colon cancer activities dose-dependently against HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10 cell lines. The best result of anti-colon cancer effects was seen in the case of the HCT 116 cell line. Conclusions It looks gold nanoparticles can be used for the treatment of several types of colon cancers in human.

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An update on nanoparticle-based contrast agents in medical imaging

Cited by 70 publications

References 148 publications

Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging

Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging

Analysis of the Exposure of Organisms to the Action of Nanomaterials

Efficient biogenesis of Au nanoparticles using extract of Mentha pulegium flower: Evaluation of catalytic reduction of nitroarenes and anti-human colon cancer properties in the in vitro condition

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