An Update on Lymphocyte Subtypes in Asthma and Airway Disease

Moldaver, Daniel M.; Larché, Mark; Rudulier, Christopher D.

doi:10.1016/j.chest.2016.10.038

Cited by 41 publications

(28 citation statements)

References 105 publications

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“…The characteristics of chronic inflammation in different conditions can be influenced by the functions of various sets of adaptive immune cells. These include the effect of immunological skewing influenced by Th1, Th2, Th17, or T‐regulatory cells, all of which can lead to different inflammatory consequences . For example, Th17 skewing influences the inflammatory response in the rheumatoid arthritic joint to generate cartilage degradation, whereas Th2 skewing in atopic dermatitis can result in skin barrier dysfunction and promotion of epithelial cell hyperplasia .…”

Section: Introductionmentioning

confidence: 99%

“…During lung inflammation, immune cell skewing can result in different pathological outcomes. For instance, classical Th1 responses lead to a pro‐inflammatory microenvironment and tissue destruction, while Th2 immunity promotes tissue remodeling, airway hyper‐responsiveness and eosinophilic infiltration . In addition to T‐cell subsets, the role of macrophage diversity is another component that is involved in skewing immune responses and pathology.…”

Section: Introductionmentioning

confidence: 99%

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Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization in vitro and in vivo

et al. 2017

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Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macrophage polarization, and find that IL-6 overexpression alone (Ad vector, AdIL-6) did not induce Arg-1 protein in mouse lungs at day 7, nor ectopic melanoma tumor growth at day 14, in contrast to overexpression of OSM (AdOSM). AdOSM elevated levels of IL-4, IL-5 and IL-13 in bronchoalveolar lavage fluid, whereas AdIL-6 did not. Bone marrow-derived macrophages respond with Arg-1 enzymatic activity to M2 stimuli (IL-4/IL-13), which was further elevated in combination with IL-6 stimulation; however, OSM or LIF had no detectable activity in vitro. Arg-1 mRNA expression induced by AdOSM was attenuated in IL-6-/- and STAT6-/- mice, suggesting requirements for both IL-6 and IL-4/IL-13 signaling in vivo. Ectopic B16 tumor burden was also reduced in IL-6-/- mice. Thus, OSM induces Arg-1+ macrophage accumulation indirectly through elevation of Th2 cytokines and IL-6 in vivo, whereas IL-6 acts directly on macrophages but requires a Th2 microenvironment, demonstrating distinct roles for OSM and IL-6 in M2 macrophage polarization.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization in vitro and in vivo

et al. 2017

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“…As IL‐33 and IL‐25 are important activators of ILC2s, and ILC2s have been recognized as an important innate cell type involved in Th2 cell sensitisation and propagation of Th2 driven disease, we determined the effect of BP SCIT on the number of ILC2s and their production of IL‐5. BP SCIT treatment greatly reduced the number of BALF and lung ILC2s (Figure A, identified as Lin − [CD3 − CD19 − B220 − DX5 − FcɛRI − GR‐1 − CD11c − ],CD45 + , ST2 + , CD127 + , CD25 + in BALF and in lung).…”

Section: Resultsmentioning

confidence: 99%

“…have been recognized as an important innate cell type involved in Th2 cell sensitisation and propagation of Th2 driven disease, 28 were suppressed by the BP SCIT treatment ( Figure 4A,B).…”

Section: Bp Scit Reduces the Number Of Ilc2smentioning

confidence: 99%

Birch pollen‐specific subcutaneous immunotherapy reduces ILC2 frequency but does not suppress IL‐33 in mice

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Logiantara

Canbaz

et al. 2018

Clin Experimental Allergy

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“…Воздействие аллергенов и разнообразных неспецифических факторов на дыхательные пути провоцирует в сенсибилизированном организме развитие острых реакций в виде бронхоспазма, отека стенки бронхов, обтурации их просвета слизью. Хроническое аллерги-ческое воспаление со временем приводит к ремоделированию бронхов [1,2,5,10,19,23,30].…”

Section: Introductionunclassified

Immune Mechanisms for Development of Controlled and Partially Controlled Asthma

et al. 2019

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Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.

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An Update on Lymphocyte Subtypes in Asthma and Airway Disease

Cited by 41 publications

References 105 publications

Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization in vitro and in vivo

Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization in vitro and in vivo

Birch pollen‐specific subcutaneous immunotherapy reduces ILC2 frequency but does not suppress IL‐33 in mice

Immune Mechanisms for Development of Controlled and Partially Controlled Asthma

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