An update on clinicopathological, immunohistochemical, and molecular profiles of colloid carcinoma of the lung

Zenali, Maryam; Weissferdt, Annikka; Solis, Luisa M.; Ali, Sara; Tang, Ximing; Mehran, Reza J.; Wistuba, Ignacio I.; Moran, César A.; Kalhor, Neda

doi:10.1016/j.humpath.2014.10.032

Cited by 22 publications

(25 citation statements)

References 21 publications

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“…The treatment strategy for CA should be based on the guidelines for primary lung cancer. In our study, two of the six cases had lymph node metastasis, similar to previous reports . Moreover, one case with pN2 had postoperative recurrence.…”

Section: Discussionsupporting

confidence: 91%

“…In our study, six patients with CA were identified (Table ). Table shows a summary of the five previous reports on CA and a comparison of those reports with our clinical data . Although our study consisted of a small series, the clinical characteristics of our patients were similar to those previously reported.…”

Section: Discussionsupporting

confidence: 64%

“…In our series, only one patient (Case 2) had distant metastasis. Past reports have shown that the recurrence pattern of CA is diverse [1,[9][10][11][12] and the frequency of loco-regional recurrence is lower than that of IMA. In our series, all but one patient had a favorable outcome.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases

Masai

Sakurai

Suzuki

et al. 2016

Journal of Surgical Oncology

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On CT, CA appears a solitary solid nodule. Further, FDG-PET findings present various (18) F-FDG accumulations. Lobectomy with systematic lymph node dissection is an appropriate procedure in view of lymph node metastasis. Since the definitive diagnosis of CA of the lung is difficult, further immunohistochemical and genetic analyses are needed. J. Surg. Oncol. 2016;114:211-215. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 64%

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Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases

Masai

Sakurai

Suzuki

et al. 2016

Journal of Surgical Oncology

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“…IMA, ICA and IEA share many phenotypic traits, which are opposed to conventional non‐mucinous adenocarcinomas and HPAME. Expression of NK2 homeobox 1/thyroid‐specific transcription factor‐1 (NKX2‐1/TTF‐1) , napsin A aspartic peptidase (NAPSA) , surfactant protein A1 (SFTPA1) , caudal type homeobox 2 (CDX2) , keratin 20 (KRT20) , mucin 1 cell surface associated (MUC1) , mucin 2 oligomeric mucus/gel‐forming (MUC2) , mucin 5AC oligomeric mucus/gel‐forming (MUC5AC) , mucin 6 oligomeric mucus/gel‐forming (MUC6) and hepatocyte nuclear factor 4 alpha (HFN4A) , have been variably reported onto emphasize the inherent heterogeneity of these tumours. Furthermore, IMA may even express neuroendocrine (NE) markers and sex steroid hormone receptors .The molecular landscape of IMA, ICA, IEA and, to lesser extent, HPAME is dominated by KRAS , TP53 and LKB1/STK11 over Epidermal Growth Factor Receptor (EGFR) mutations , while the CD74‐NRG1 fusion genes has been documented in 13–27% KRAS ‐wild type tumours .…”

Section: Introductionmentioning

confidence: 99%

Pulmonary adenocarcinoma with mucin production modulates phenotype according to common genetic traits: a reappraisal of mucinous adenocarcinoma and colloid adenocarcinoma

Sonzogni¹,

Bianchi

Fabbri

et al. 2017

The Journal of Pathology CR

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Whether invasive mucinous adenocarcinoma (IMA) and colloid adenocarcinoma (ICA) of the lung represent separate tumour entities, or simply lie within a spectrum of phenotypic variability, is worth investigating. Fifteen ICA, 12 IMA, 9 ALK‐rearranged adenocarcinomas (ALKA), 8 non‐mucinous KRAS‐mutated adenocarcinomas (KRASA) and 9 mucinous breast adenocarcinomas (MBA) were assessed by immunohistochemistry for alveolar (TTF1, cytoplasmic MUC1), intestinal (CDX‐2, MUC2), gastric (membrane MUC1, MUC6), bronchial (MUC5AC), mesenchymal (vimentin), neuroendocrine (chromogranin A, synaptophysin), sex steroid hormone‐related (oestrogen and progesterone receptors), pan‐mucinous (HNF4A) and pan‐epithelial (keratin 7) lineage biomarkers and by targeted next generation sequencing (TNGS) for 50 recurrently altered cancer genes. Unsupervised clustering analysis using molecular features identified cluster 1 (IMA and ICA), cluster 2 (ALKA and KRASA) and cluster 3 (MBA) (p < 0.0001). Cluster 1 showed four histology‐independent sub‐clusters (S1 to S4) pooled by HFN4A and MUC5AC but diversely reacting for TTF1, MUC1, MUC2, MUC6 and CDX2. Sub‐cluster S1 predominantly featured intestinal‐alveolar, S2 gastrointestinal, S3 gastric and S4 alveolar differentiation. In turn, KRASA and ALKA shared alveolar lineage alongside residual MUC5AC expression, with additional focal CDX2 and diffuse vimentin, respectively. A proximal‐to‐distal scheme extending from terminal (TB) and respiratory (RB) bronchioles to alveolar cells was devised, where S3 originated from distal TB (cellular mucinous adenocarcinoma), S2 from proximal RB (secreting mucinous adenocarcinoma), S1 from intermediate RB (mucin lake‐forming colloid adenocarcinoma), S4 from distal RB (colloid alveolar adenocarcinoma), KRASA from juxta‐alveolar RB (KRAS‐mutated non‐mucinous adenocarcinoma) and ALKA from juxta‐bronchial alveolar cells (ALK‐translocated adenocarcinoma). TNGS analysis showed KRAS, LKB1, TP53, APC and CDKN2A mutation predominance. In conclusion, IMA and ICA are basket categories, which likely originate from distinct domains of stem/progenitor cells spatially distributed along bronchioles upon common molecular features and genetic alterations.

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“…Zenali MJ et al (2015) 17 indicated frequent CDX2 expression in colloid carcinomas. Immuspecifi c in distinguishing primary and metastatic adenocarcinomas of the lung, because in certain types of mucin-producing lung tumors, especially mucinous BAC, TTF1 expression often is absent.…”

Section: Egfr Mutationsmentioning

confidence: 98%

Comparative Characteristics of Napsin A, TTF 1 and EGFR Mutation Expression in Mucinous Lung Cell Carcinomas

et al. 2017

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Background: Invasive mucinous lung adenocarcinomas are rare and account for 2%-10% of all lung adenocarcinoma cases. It is believed that Napsin A exhibits a weaker expression in mucinous adenocarcinomas compared with TTF1, but such correlation is still poorly researched. Aim: The aim of the study was to determine the frequency of mucinous to nonmucinous adenocarcinomas and compare specifi city and sensitivity of monoclonal Napsin A with TTF1 in mucinous adenocarcinomas and defi ne the frequency of EGFR mutations. Materials and methods: Eighty-four resected lung carcinomas were prospectively evaluated. All biopsies were analysed with p63, TTF1, monoclonal Napsin A, CK7, CK20 and CDX2 and were studied with real-time PCR technology. Results: In resected material we detected 49/84 (58.3%) adenocarcinomas and selected 21 mucinous adenocarcinomas out of 46 non-mucinous adenocarcinomas (45.6%). The most common pattern of mucinous adenocarcinomas is papillary -24% and colloidal -24%, followed by acinar -19.2% and lepidic -19.2%. mNapsin A was positive in 18/21 (85.7%) mucinous adenocarcinomas v/s 17/21 TTF1 positive (80.9%). EGFR mutations were detected in 3/21 cases with mucinous adenocarcinomas (14.3%): mucinous papillary, mucinous acinar and "salivary gland-like". Conclusion: Our study demonstrates a high proportion of primary mucinous lung adenocarcinomas to primary non-mucinous adenocarcinomas. Sensitivity and specifi city of mNapsin A and TTF1 did not show signifi cant diff erence in pulmonary mucinous and non-mucinous adenocarcinomas, as mNapsin A gave greater sensitivity to mucinous adenocarcinomas. Our results indicate the same mutation frequency of EGFR in mucinous adenocarcinomas as mutation frequency detected in non-mucinous adenocarcinomas in the Bulgarian region.

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An update on clinicopathological, immunohistochemical, and molecular profiles of colloid carcinoma of the lung

Cited by 22 publications

References 21 publications

Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases

Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases

Pulmonary adenocarcinoma with mucin production modulates phenotype according to common genetic traits: a reappraisal of mucinous adenocarcinoma and colloid adenocarcinoma

Comparative Characteristics of Napsin A, TTF 1 and EGFR Mutation Expression in Mucinous Lung Cell Carcinomas

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