Comparative Characteristics of Napsin A, TTF 1 and EGFR Mutation Expression in Mucinous Lung Cell Carcinomas

Genova, Sylvia; Belovezhdov, Veselin; Bichev, Stoyan; Danev, Vladimir H.

doi:10.1515/folmed-2017-0020

Cited by 1 publication

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References 19 publications

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“…They observed that 2/21 (10%) of lung adenocarcinomas showed loss of protein expression. Reactivity to TTF-1 and napsin-A IHC stains can assist in confirming a pulmonary primary and exclude pancreatic and GCxACa primary in the setting of DPC4 loss (41). Pulmonary mucinous adenocarcinoma often harbors EGFR, KRAS, and GNAS mutations (42,43) and the Cancer Genome Atlas showed that DPC4 mutation can be seen in up 6% of lung cancers (14).…”

Section: Dpc4 Loss In Gynecologic Tumorsmentioning

confidence: 99%

Immunohistochemical Loss of DPC4 in Tumors With Mucinous Differentiation Arising in or Involving the Gynecologic Tract

Kwon

Malpica

Zaleski

et al. 2021

International Journal of Gynecological Pathology

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DPC4 immunohistochemistry (IHC) is usually part of the work-up of mucinous neoplasms in the ovary where the distinction between an ovarian primary and metastatic pancreaticobiliary adenocarcinoma (PanACa) must be made. Although DPC4 IHC is lost in about 55% (46%-61%) of PanACas and typically retained in most primary ovarian mucinous neoplasms, no study has evaluated the expression of this marker in a large cohort of neoplasms arising in or involving gynecologic (GYN) organs. In this study, we retrospectively analyzed the expression of DPC4 IHC in a total of 251 tumors and lesions related to the GYN tract in which DPC4 IHC stain was performed during the initial pathology evaluation. Of these, 138 were primary GYN tumors and lesions, 31 were metastatic GYN tumors involving non-GYN sites, and 83 were metastatic non-GYN tumors involving the GYN tract. We identified 27 cases with loss of DPC4 IHC expression of which 20 cases met the inclusion criteria (i.e. clinical information was available to determine the site of tumor origin). We observed that loss of DPC4 nuclear expression was most commonly seen in tumors of endocervical origin (n = 7), of which 5 were gastric-type cervical adenocarcinomas (GCxACa) and 2 were usual-type cervical adenocarcinomas, either primary or metastatic. This was followed by tumors of the pancreaticobiliary tract (n = 5), ovary (n = 2), and appendix (n = 1). In addition, 1 gastrictype vaginal adenocarcinoma (GVaACa) also showed loss of DPC4. Our findings indicate that in female patients with mucinous neoplasms involving the ovary or other sites, with loss of DPC4 by IHC, and negative pancreaticobiliary imaging, the possibility of an occult GCx/GVaACa, and rarely an ovarian primary must be considered.

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