An Update on Cancer- and Chemotherapy-Related Cognitive Dysfunction: Current Status

Janelsins, Michelle Christine; Kohli, Sadhna; Mohile, Supriya G.; Usuki, K.Y.; Ahles, Tim A.; Morrow, Gary R.

doi:10.1053/j.seminoncol.2011.03.014

Cited by 296 publications

(242 citation statements)

References 81 publications

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“…fMRI | machine learning B reast cancer (BC) chemotherapy is associated with cognitive dysfunction based on both human and animal research (1,2). The exact mechanisms of this dysfunction remain unclear, although there is emerging evidence that chemotherapy may accelerate cognitive and brain aging.…”

mentioning

confidence: 99%

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Kesler

Wefel²,

Hosseini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

105

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Breast cancer (BC) chemotherapy is associated with cognitive changes including persistent deficits in some individuals. We tested the accuracy of default mode network (DMN) resting state functional connectivity patterns in discriminating chemotherapy treated (C+) from non–chemotherapy (C−) treated BC survivors and healthy controls (HC). We also examined the relationship between DMN connectivity patterns and cognitive function. Multivariate pattern analysis was used to classify 30 C+, 27 C−, and 24 HC, which showed significant accuracy for discriminating C+ from C− (91.23%, P < 0.0001) and C+ from HC (90.74%, P < 0.0001). The C− group did not differ significantly from HC (47.06%, P = 0.60). Lower subjective memory function was correlated ( P < 0.002) with greater hyperplane distance (distance from the linear decision function that optimally separates the groups). Disrupted DMN connectivity may help explain long-term cognitive difficulties following BC chemotherapy.

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mentioning

confidence: 99%

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Kesler

Wefel²,

Hosseini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

105

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“…Por todo ello, no se puede descartar que puedan jugar un papel importante en el deterioro cognitivo relacionado con la QT. De hecho, se ha sugerido que aunque la QT causa neurotoxicidad, la inflamación podría actuar de mediador reduciendo la transmisión neural (1) .…”

Section: Citoquinasunclassified

“…Entre ellas se encuentran las complicaciones vasculares, las crisis convulsivas, las alteraciones psicológicas y el deterioro cognitivo. Actualmente, se admite que hasta el 75% de los pacientes con cáncer pueden experimentar una disminución de la función cognitiva (FC) durante o después del tratamiento antineoplásico (1) . Esta alteración a menudo es transitoria, pero puede ser persistente (meses o años) en el 17-35% de los casos.…”

Section: Introducción Y Magnitud Del Problemaunclassified

Bases biológicas del deterioro de la función cognitiva inducido por los tratamientos antineoplásicos

et al. 2012

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Often patients treated with chemotherapy and/or radiotherapy suffer memory and attention problems. The exact mechanisms of action are unknown, although several explanations have been proposed. Both chemotherapy and radiotherapy have a direct toxic effect in the CNS, especially neural progenitor cells and the glia, which are responsible for maintaining neurogenesis in the hippocampus and white matter integrity. Besides the treatments can induce vascular damage in the brain, altering the immune response mediated by cytokines, and hormonal changes secondary to either chemotherapy or hormone therapy itself. The intensity of these effects would be modulated by several genetic factors that influence the ability of neuronal repair, pharmacodynamics and activity of neurotransmitters. Keywords: Cognitive function, cancer, chemotherapy, radiotherapy, chemobrain. ResumenA menudo los pacientes que reciben tratamiento con quimioterapia y/o radioterapia presentan problemas de memoria y de atención. Se desconocen los mecanismos exactos por los que esto se produce, aunque se han propuesto diversas explicaciones. Tanto la quimioterapia como la radioterapia poseen una acción tóxica directa en el SNC, especialmente sobre las células progenitoras neurales y las de la glía, que son las responsables de mantener la neurogénesis del hipocampo y la integridad de la sustancia blanca. A ello cabe añadir el daño que pueden inducir los tratamientos en la vascularización cerebral, la alteración de la respuesta inmune mediada por citoquinas, y los cambios hormonales ya sean secundarios a la quimioterapia o a la propia hormonoterapia. La intensidad de estos efectos estaría modulada por diversos factores genéticos que influyen sobre la capacidad de reparación neuronal, la farmacodinamia y la actividad de los neurotransmisores.

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“…Methotrexate, 5-Flourouracil (5-FU) the most common chemotherapy drugs used to treat breast, colorectal, head and neck cancers been shown in both rodent models and clinical studies to lead to neurocognitive deficits in a variety of domains including visual memory and visuospatial functioning [11,13,14]. In clinical studies, there is considerable variability between studies as to the extent and frequency of such impairments heretofore mentioned.…”

Section: Chemotherapy Apoe and Memorymentioning

confidence: 99%

The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes

Acevedo¹

2012

Lipoproteins - Role in Health and Diseases

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An Update on Cancer- and Chemotherapy-Related Cognitive Dysfunction: Current Status

Cited by 296 publications

References 81 publications

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Bases biológicas del deterioro de la función cognitiva inducido por los tratamientos antineoplásicos

The Confounding Factor of Apolipoprotein E on Response to Chemotherapy and Hormone Regulation Altering Long-Term Cognition Outcomes

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