An update on biomarkers of heart failure in hypertensive patients

Gluba, Anna; Bielecka‐Dąbrowa, Agata; Mikhailidis, Dimitri P.; Wong, Nathan D; Franklin, Stanley S.; Rysz, Jacek; Banach, Maciej

doi:10.1097/hjh.0b013e3283569a9c

Cited by 47 publications

(37 citation statements)

References 109 publications

(187 reference statements)

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“…Biomarker research in the field of muscle wasting is active [70,71]. Serum creatinine levels are understood to be an unspecific marker of muscle wasting [72], but recently a more specific marker (C-terminal agrin fragment) was described [73].…”

Section: Search Strategymentioning

confidence: 99%

Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology

Anker

Haehling

Springer

et al. 2013

International Journal of Cardiology

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Section: Search Strategymentioning

confidence: 99%

Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology

Anker

Haehling

Springer

et al. 2013

International Journal of Cardiology

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“…MCP-1 has been reported to be elevated in hypertensive patients with symptoms of heart failure (Gluba et al 2012). These inflammatory mediators have also been suggested to be involved in the processes of cardiac remodelling, including fibrosis and hypertrophy (Kubota et al 1997;Mann 2002).…”

Section: Discussionmentioning

confidence: 99%

Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice

et al. 2014

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Current epidemiological studies suggest that crystalline silica exposure is associated with an increased risk of cardiovascular and renal disease; however, the potential pathological damage of the heart and kidney and its underlying mechanisms have not been completely elucidated. This study tried to investigate the silica-induced inflammatory and fibrotic changes in the heart and kidney and evaluate the role of interleukin (IL)-1 beta (β) in silica-induced cardiac and renal damage. In this study, a silica-exposed model was generated by intratracheally instilling silica dust in mice. The anti-IL-1β monoclonal antibody (mAb) was used to neutralise IL-1β in the pulmonary alveolus and serum. The real-time PCR studies showed that (1) inhalational silica induced inflammatory responses in the heart and kidney by elevated mRNA levels of TNF-α, IL-6 and MCP-1; (2) early fibrotic responses in the heart were observed as elevated mRNA levels of collagen I and fibronectin. What is more, fibrosis of the kidney was demonstrated by pathological results and significantly increased mRNA levels of TGF-β, collagen I, collagen III and fibronectin. Further studies showed that usage of anti-IL-1β mAb decreased the inflammatory response of the heart and kidney induced by inhalational silica and also attenuated fibrosis in the mouse kidney. In conclusion, this study found that inhaled silica induced inflammatory and early fibrotic responses in the mouse heart and inflammatory response and fibrosis in the mouse kidney. Neutralisation of IL-1β attenuated the silica-induced inflammatory response of the heart and kidney and decreased fibrosis in the mouse kidney.

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“…by the heart's ventricles in response to volume expansion and the pressure load [11]. The serum NT-proBNP test is recommended as a diagnostic tool for heart failure by the American Heart Association [12].…”

Section: N-terminal Pro-b-type Natriuretic Peptide (Nt-probnp) Is Secmentioning

confidence: 99%

Factors Related to N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for Heart Failure

Lee¹,

Choi²,

Oh³

2016

jkbns

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ly leads to hospitalization and high treatment costs which are more than 800 billion won per year [4].Patients with heart failure experience physical symptoms, including fatigue, dyspnea, and generalized edema, depending on the condition's severity. These physical symptoms can have psychological effects, for example, anxiety, depression, and reduced self-efficacy, which can hinder daily activities, work, and a person's social life [6]. Heart failure is difficult to cure, and its characteristics often include recurrent cycles of deterioration and improvement. Consequently, rehospitalization rates con- Purpose: This study aimed to examine the relationships between the N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels with the sociodemographic and clinical factors, self-care behaviors, and the physical symptom experiences in patients with heart failure. Methods: This cross-sectional study utilized a convenience sample of adult outpatients and inpatients who attended a cardiology department in a tertiary hospital in Seoul, Korea. The data from 154 patients with heart failure were collected using a questionnaire, and their clinical data were extracted from their electronic medical records. Results: Compared with the patients with high NTproBNP levels, those with low NT-proBNP levels had significantly lower physical symptom experiences scores. Patients with low-and mid-NT-proBNP levels were more likely to be employed compared with those with high NT-proBNP levels. Patients with low NT-proB-NP levels had higher left ventricular ejection fractions, and were less likely to have arrhythmias and comorbidities. Conclusion: The results from this study showed that patients with more severe heart failure had higher physical symptom experiences scores; hence, individualizing treatment approaches based on heart failure severity is necessary. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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An update on biomarkers of heart failure in hypertensive patients

Cited by 47 publications

References 109 publications

Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology

Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology

Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice

Factors Related to N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for Heart Failure

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