An Unusual Successfully Treated Case of Pulmonary Yolk Sac Tumor

Chen, Chih‐Hao; Chen, Tze-Chien; Huang, Wen‐Chien; Chen, Tung-Ying; Liu, Hung-Chang

doi:10.1016/j.athoracsur.2007.08.030

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…We therefore diagnosed primary lung YST with metastatic intracardiac YST. Primary lung YST is very rare and only few cases have ever been reported [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Case report of death from falling: Did heart tumor cause syncope?

et al. 2011

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A healthy man in his 30s was working on the balustrade of stairs on the second floor. He suddenly fell downstairs without saying anything. On emergency hospitalization, chest echogram showed left hemothorax. Cardiac echogram showed a floating mass from the mitral valve in the left ventricle and severe mitral regurgitation. Surgery for hemothorax and pulmonary contusion was immediately undertaken. However, bleeding from pulmonary contusion could not be controlled and he underwent cardiopulmonary arrest. Autopsy showed a white, elastic, pendulous mass in the left atrium and a white mass in the lower lobe of the left lung. Tumor histology showed a reticular pattern, Schiller-Duval bodies, eosinophilic hyaline globules, and positive staining for α-fetoprotein. We diagnosed primary lung yolk sac tumor with metastatic intracardiac yolk sac tumor, a rare and highly malignant germ cell tumor. It usually arises in the ovaries and testes, and intracardiac yolk sac tumor is rare. Intracavitary tumors induce obstruction of inflow into and outflow from the ventricular cavity. The most common clinical presentation is dyspnea and syncope. In the present case, metastatic cardiac yolk sac tumor might have disturbed cardiac outflow and affected hemodynamics, probably causing syncope. Unfortunately, he was in a high place at that time and fell to receive pulmonary contusion that led to death. Autopsy may sometimes reveal latent diseases which might be related to the cause of death. We should perform autopsy thoroughly to diagnose not only the cause of death but also the factors leading to death.

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“…We therefore diagnosed primary lung YST with metastatic intracardiac YST. Primary lung YST is very rare and only few cases have ever been reported [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Case report of death from falling: Did heart tumor cause syncope?

et al. 2011

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“…1B). 1 CT scans of the abdomen and pelvis showed ascites. A heterogeneous enhancement was noted in the liver with possible metastatic lesions.…”

Section: Case Reportsmentioning

confidence: 97%

“…Extragonadal germ cell tumors typically occur in the anterior mediastinum or less frequently in other midline structures. 1 Germ cell tumors, particularly yolk sac tumors, arising from lung parenchyma is one of the rarest conditions in human and only a few cases of choriocarcinomas and yolk sac tumor have been reported to date. 1,2 We are presenting a very rare case of primary mixed germ cell tumor of the lung initially encountered on fine-needle aspiration (FNA) of the lung.…”

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confidence: 99%

Aspiration biopsy cytomorphology of primary pulmonary germ cell tumor metastatic to the brain

Arabi

Shah

Saleh

2009

Diagnostic Cytopathology

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Extragonadal germ cell tumors are uncommon and such tumors originating from the lung parenchyma are extremely rare. This is a case of 68-year-old female who was admitted with complaints of right-sided weakness, inability to maintain her balance, right-sided headache, and bloody sputum. Her workup revealed two enhancing brain lesions and large lung mass involving the left lower lobe. Fine-needle aspiration (FNA) of the lung followed by craniotomy was performed and the patient was initially diagnosed with lung adenocarcinoma metastatic to the brain based on the cytomorphology of the lung FNA and histology of the brain mass. However, retrospective investigation revealed markedly elevated alpha fetoprotein (AFP) of which the cytopathologist was unaware at the time of diagnosis. A review of the cytology and surgical specimen slides, as well as immunohistochemistry (IHC) on the brain tumor and FNA cell block were preformed. On the basis of the slides review, clinical findings, and immunostaining results, a diagnosis of primary pulmonary mixed germ cell tumor, containing choriocarcinoma and yolk sac elements, with brain metastases, was retrospectively made.

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