An unusual rash for Royal: a case series

Booth, Boynton H.; Furzeland, Jacqueline

doi:10.1136/jrnms-102-19

Cited by 2 publications

(1 citation statement)

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“…Moraceae, or the Mulberry family, contains the fig tree (Ficus caricu), perhaps its most well-known phototoxic plant. While fig has been used on vitiligo for millennia, recent case reports continue to show fig to be an underrecognized cause of phytophotodermatitis outbreaks [3,7,10,14,38,39]. The highest concentrations of furocoumarins are in the fig leaves and the shoot sap, particularly during spring or summer [40].…”

Section: Moraceaementioning

confidence: 99%

Phytophotodermatitis

Nguyen¹,

Muhammad²,

Lee³

2020

Dermatological Manual of Outdoor Hazards

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PUVAPsoralen and Ultraviolet A Radiation ROS Reactive Oxygen Species UVA Ultraviolet A Radiation Background/IntroductionCertain plant compounds may be toxic via direct human skin contact, while others may become phototoxic when combined with light. Dr. Robert Klaber originally coined the term "phytophotodermatitis" in a 1942 publication of the British Journal of Dermatology and Syphilis. Dr. Klaber suggested this term to describe the phenomenon of human skin eruptions produced by photosensitizing plants and their extracts upon exposure to sunlight [1]. Phytophotodermatitis may have only recently been coined as a term, but historical characterizations have been described as far back as 2000 B.C. in Egypt [2]. Egyptians used the Apiaceae plant family species Ammi majus, also known as false Bishop's Weed, to treat vitiligo [2,3]. Apiaceae (formerly known as Umbelliferae) is among the commonly implicated plant families along with Rutaceae and

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Section: Moraceaementioning

confidence: 99%

Phytophotodermatitis

Nguyen¹,

Muhammad²,

Lee³

2020

Dermatological Manual of Outdoor Hazards

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New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants

Grosu (Dumitrescu),

Jîjie,

Manea

et al. 2024

Life

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The present review explores the underlying mechanisms of phytophotodermatitis, a non-immunologic skin reaction triggered by certain plants followed by exposure to ultraviolet radiation emitted by sunlight. Recent research has advanced our understanding of the pathophysiology of phytophotodermatitis, highlighting the interaction between plant-derived photosensitizing compounds (e.g., furanocoumarins and psoralens) and ultraviolet light leading to skin damage (e.g., erythema, fluid blisters, edema, and hyperpigmentation), identifying these compounds as key contributors to the phototoxic reactions causing phytophotodermatitis. Progress in understanding the molecular pathways involved in the skin’s response to these compounds has opened avenues for identifying potential therapeutic targets suitable for the management and prevention of this condition. The review emphasizes the importance of identifying the most common phototoxic plant families (e.g., Apiaceae, Rutaceae, and Moraceae) and plant species (e.g., Heracleum mantegazzianum, Ruta graveolens, Ficus carica, and Pastinaca sativa), as well as the specific phytochemical compounds responsible for inducing phytophototoxicity (e.g., limes containing furocoumarin have been linked to lime-induced photodermatitis), underscoring the significance of recognizing the dangerous plant sources. Moreover, the most used approaches and tests for accurate diagnosis such as patch testing, Wood’s lamp examination, or skin biopsy are presented. Additionally, preventive measures such as adequate clothing (e.g., long-sleeved garments and gloves) and treatment strategies based on the current knowledge of phytophotodermatitis including topical and systemic therapies are discussed. Overall, the review consolidates recent findings in the field, covering a diverse array of phototoxic compounds in plants, the mechanisms by which they trigger skin reactions, and the implications for clinical management. By synthesizing these insights, we provide a comprehensive understanding of phytophotodermatitis, providing valuable information for both healthcare professionals and researchers working to address this condition.

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An unusual rash for Royal: a case series

Cited by 2 publications

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Phytophotodermatitis

Phytophotodermatitis

New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants

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