An Unusual Primary Renal Lymphoma

Mansouri, Hamid; Gaye, M.; Hassouni, Khalid; Errihani, Hassan; Kettani, Fouad; Gueddari, B.K. El

doi:10.1159/000065567

Cited by 5 publications

(8 citation statements)

References 7 publications

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“…Dimopoulus et al [11] showed that 3% of the renal masses that had radiological findings were suggestive of renal cell carcinoma diagnosed finally as primary renallymphoma.ThetumorcanalsobefoundbyCTduring a check-up for hematuria and weight loss [12]. Our 4 cases werecharacterizedbyasolitaryrenalmassormultiplerenal masses.Whilethefirstandthethirdcasewerediagnosedas primary renal lymphoma by nephrectomy, the second case wasdiagnosedbyopenexcisionalrenalbiopsyundergeneral anesthesia.Allofourcaseswereinitiallyacceptedasarenal cellcarcinomaandthereforereferredtotheurologyclinic.…”

Section: Discussionmentioning

confidence: 99%

Primary Renal Lymphoma: Report of Four Cases

Köse¹,

Sakallı²,

Mertsoylu³

et al. 2009

Oncol Res Treat

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Background: Although secondary renal involvement from systemic lymphoma is very frequent, primary renal lymphoma is a rare entity. It is characterized by aggressive histopathology, very early extra-renal infiltration and poor prognosis. Case Reports: Here, we report 4 cases of primary renal lymphoma presenting with unilateral renal masses, which after radiological and clinical examination were assumed to be renal cell carcinoma. 3 patients were diagnosed with Non-Hodgkin’s lymphoma by nephrectomy and one patient was diagnosed by open renal biopsy. Histopathological subtypes were diffuse large B cell lymphoma in 2 cases and non-Hodgkin’s lymphoma of small B cell type in the others. While 3 of the patients were treated with systemic chemotherapy, the fourth patient refused chemotherapy. 2 patients (no. 2 and 3) were still in complete remission and were followed regularly in the second and first year after diagnosis, respectively. Conclusions: Since it is difficult to diagnose primary renal lymphoma, most patients with this kind of tumor undergo radical nephrectomy, and diagnosis of primary renal lymphoma is delayed. The authors believe that both the delayed diagnosis due to anatomical difficulties and the histological aggressive characteristics of this disease are equally responsible for the poor outcome in the case of primary renal lymphoma.

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Section: Discussionmentioning

confidence: 99%

Primary Renal Lymphoma: Report of Four Cases

Köse¹,

Sakallı²,

Mertsoylu³

et al. 2009

Oncol Res Treat

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“…Ultrasonography of the reported cases of PRNHL in the kidney shows a hypoechoic mass. 10 Typical CT patterns in PRNHL are the presence of multiple and bilateral hypovascular renal masses (reported in 60% of cases), renal invasion from contiguous retroperitoneal disease (reported in 25%–30% of cases), presence of peri-renal disease, and diffuse renal infiltration (reported in 20% of cases). Atypical findings include spontaneous hemorrhage, necrosis, heterogeneous attenuation, cystic transformation, and calcification.…”

Section: Resultsmentioning

confidence: 99%

“…9 The diagnosis of PRNHL can be made when there is a renal mass in the absence of a leukemic blood picture and no evidence of extra-renal lymphoma in the other organs or lymph nodes as the first presentation. 10 PRNHL most commonly occurs in adults. It is common to be bilateral in contrast to other adult renal tumors.…”

Section: Discussionmentioning

confidence: 99%

“…20 Presence if atypical imaging findings such as bilateral tumor in an adult or hypovascularity in imaging, should be considered as an indication for tissue biopsy before nephrectomy. [6][7][8][9][10] In some reports, fine-needle biopsy under CT guidance has been recommended to detect lymphomatous infiltration, for possible sparing of the patient from nephrectomy, which can be considered as a primary intervention when there is bilateral renal involvement, homogeneous renal enlargement without an obvious mass, multiple renal nodules, and hypovascular tumor. 16 In the cases with pre-operative diagnosis of NHL, no nephrectomy has been recommended especially in high grade NHLs.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, 83 cases of primary NHL of the kidney have been reported in the English literature so far. 3 –69 Herein we will review all the primary renal NHL (PRNHL) reported in the English literature and will report all the clinicopathologic findings in the published cases.…”

Section: Introductionmentioning

confidence: 99%

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Primary renal non-Hodgkin’s lymphoma: A narrative review of literature

2021

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Renal involvement by Non-Hodgkin’s lymphoma (NHL) is very rare, and involvement of the kidney as the primary site of NHL (PRNHL) is much more uncommon. Gold standard for the diagnosis of PRNHL is histology and imaging modalities although helpful are not specific. Nephrectomy has been mostly recommended for low grade lymphomas, and for high grade PRNHLs, chemotherapy without nephrectomy has been recommended as the treatment of choice. This tumor is aggressive with poor prognosis. This poor prognosis is partly because of delayed diagnosis and partly because of unnecessary surgeries, so it should be kept in mind, especially in bilateral renal tumors with unusual imaging characteristics, to take a tissue biopsy before nephrectomy. In this review, we will discuss all the detailed aspects of clinical, pathologic, and imaging characteristics of 83 cases of PRNHL reported in the last 20 years in the English literature so far. For this purpose, all the published cases of the primary non-Hodgkin’s lymphoma of kidney were reviewed via a search in PubMed, Scopus, and Google Scholar, (1999–2019), using the keywords of “Primary renal lymphoma” and “Non-Hodgkin’s lymphoma and kidney,” “renal Non-Hodgkin’s lymphoma,” “renal lymphoma,” and “lymphoma and kidney.” There were 83 cases in the published English literature which were reviewed for this article. There was some missing information in some cases which has been recorded as “not reported.”

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