Primary Renal Lymphoma: Report of Four Cases

Abstract

Background: Although secondary renal involvement from systemic lymphoma is very frequent, primary renal lymphoma is a rare entity. It is characterized by aggressive histopathology, very early extra-renal infiltration and poor prognosis. Case Reports: Here, we report 4 cases of primary renal lymphoma presenting with unilateral renal masses, which after radiological and clinical examination were assumed to be renal cell carcinoma. 3 patients were diagnosed with Non-Hodgkin’s lymphoma by nephrectomy and one patient was diagnosed by open renal biopsy. Histopathological subtypes were diffuse large B cell lymphoma in 2 cases and non-Hodgkin’s lymphoma of small B cell type in the others. While 3 of the patients were treated with systemic chemotherapy, the fourth patient refused chemotherapy. 2 patients (no. 2 and 3) were still in complete remission and were followed regularly in the second and first year after diagnosis, respectively. Conclusions: Since it is difficult to diagnose primary renal lymphoma, most patients with this kind of tumor undergo radical nephrectomy, and diagnosis of primary renal lymphoma is delayed. The authors believe that both the delayed diagnosis due to anatomical difficulties and the histological aggressive characteristics of this disease are equally responsible for the poor outcome in the case of primary renal lymphoma.

Lymphoproliferative Disorders of the Kidney on Fine-Needle Aspiration: Cytomorphology and Radiographic Correlates in 33 Cases

“…Otherwise, it has been briefly discussed in larger FNA series [5,7,8,9] or as small groups of case reports in the surgical pathology or oncology literature [10,11,12,13]. This series confirms that image-guided FNA is an accurate technique for diagnosing renal cell lymphoma, with only 2 nondiagnostic FNAs found in the series.…”

A unique case of kidney’s collecting system MALT lymphoma

“…[8][9] Primary renal lymphoma typically presents in age above 40, with flank pain, weakness, weight loss, hematuria, abdominal mass or renal failure. [4][5] Kidney does not have lymphoid tissue, 10 but repetitive injury to renal lymphatics due to chronic inflammation may cause malignant transformation to neoplasia of the lymphoid tissue. This occurs in extra nodal MALT lymphoma, which affects the skin, the gastrointestinal tract and the breast.…”

“…12 Diagnosis is a challenge; it is sometimes difficult to distinguish MALT lymphomas from more common tumours, such as renal cell carcinoma (RCC), in imaging studies; diagnosis, however, can be confirmed with a CT-guided biopsy of the mass. 4 In most cases, diagnosis is made after radical nephrectomy for the suspected RCC. MALT lymphomas can be treated with chemotherapy, surgical intervention or radiotherapy.…”

Rare case of malignant lymphoma of kidney

“…Medical records and literature mention several cases of malignant kidney lymphoma [1, 2]. Some authors claim that this entity accounts for 3% of all solid renal tumors among adults [3].…”