An Unusual Presentation of Endocarditis Caused by Staphylococcus warneri

Kini, Ganesh D; Patel, Ketan; Parris, Addison R; Tang, Jane S

doi:10.2174/1874285801004010103

Cited by 31 publications

(33 citation statements)

References 14 publications

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“…In all the five cases the patients were symptomatic, having signs of infection. Only one case is similar with ours,11 an immunocompetent elderly woman with no previous risk factors, presenting with congestive heart failure without signs of infection. The mitral valve was affected, with regurgitation caused by flail of the posterior leaflet.…”

Section: Discussionsupporting

confidence: 80%

Native valve endocarditis withStaphylococcus warneri

Diaconu¹,

Golumbeanu²,

Constantin³

et al. 2019

BMJ Case Rep

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We report a rare case of native valve endocarditis caused by Staphylococcus warneri in an immunocompetent 79-year-old man with known degenerative valvular heart disease but no previous risk factors such as recent invasive treatment or medical implant. The patient presented with heart failure, due to perforation of the mitral valve, and lacked any signs of infection. The diagnosis of endocarditis with S. warneri was established by echocardiography and positive blood cultures.

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Section: Discussionsupporting

confidence: 80%

Native valve endocarditis withStaphylococcus warneri

Diaconu¹,

Golumbeanu²,

Constantin³

et al. 2019

BMJ Case Rep

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“…Similar to our findings, other studies identified S. haemolyticus as the second most common CoNS species isolated from blood cultures, which can cause different infections such as sepsis, peritonitis, otitis, and urinary infection [16]. Staphylococcus hominis has been identified in cases of bacteremia [17] and S. warneri, S. capitis and S. lugdunensis have been associated with serious infections such as endocarditis [18][19][20].…”

Section: Discussionsupporting

confidence: 87%

Expression of superantigens and the agr system in Staphylococcus epidermidis

Pereira

Pinheiro

Oliveira

et al. 2018

Microbial Pathogenesis

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Infections with coagulase-negative staphylococci (CoNS) can involve the production of toxins such as superantigens, which contribute to tissue degradation and inflammatory immune responses. The accessory gene regulator (agr) quorum sensing system coordinates the expression of most S. aureus virulence factors. Therefore, the aim of this study was to investigate the expression of these superantigens and the presence of the agr locus in CoNS strains isolated from blood cultures. PCR was used to detect enterotoxin and agr genes and expression was analyzed by RT-PCR. Expression of the sea gene was observed in one S. epidermidis isolate andof sec-1 in two, seg and sei were expressed concomitantly in one isolate, and sei was expressed in another isolate. The agr group I was detected in S. epidermidis expressing the sea, seg and sei genes, whereas agr group II was detected in isolates expressing thesec-1 gene. The agr groups were only expressed in strains expressing thesec-1 gene. The results show that enterotoxin genes are highly frequent in CoNS isolated from clinical specimens and confirm the toxin-producing ability of these strains. The agr group II may be associated with enterotoxin C production by S. epidermidis, increasing the virulence of strains isolated from blood cultures and consequently the severity of sepsis caused by these organisms.

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“…Staphylococcus warneri ( S. warneri ) is a member of the CoNS family and is also isolated from body surfaces ( 14 , 15 ). S. warneri typically gives rise to clinical problems in patients with a compromised immune system or implanted prosthetic devices ( 16 , 17 ). IE, especially NVE, caused by S. warneri is very rare, and there are few reports in the literature ( 16 - 25 ).…”

Section: Introductionmentioning

confidence: 99%

Native Valve Endocarditis due to<i> Staphylococcus warneri</i> Developing in a Patient with Type 1 Diabetes

et al. 2020

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A 59-year-old man with type 1 diabetes presented with heart failure. Echocardiography showed large vegetations on the mitral and aortic valves. Blood bacterial culture was positive for Staphylococcus warneri , a coagulase-negative staphylococcus (CoNS) family member. He was diagnosed with native valve endocarditis (NVE) induced by the resident bacteria and ultimately underwent double valve replacement. Retrospectively, slight laboratory data abnormalities and weight loss beginning four months before may have been signs of NVE. He had no history of immunosuppressive therapies or medical device implantation. Thus, CoNS can cause NVE after a long asymptomatic course in patients with poorly controlled diabetes.

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An Unusual Presentation of Endocarditis Caused by Staphylococcus warneri

Cited by 31 publications

References 14 publications

Native valve endocarditis withStaphylococcus warneri

Native valve endocarditis withStaphylococcus warneri

Expression of superantigens and the agr system in Staphylococcus epidermidis

Native Valve Endocarditis due to<i> Staphylococcus warneri</i> Developing in a Patient with Type 1 Diabetes

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