An unusual presentation of aggressive epithelial-myoepithelial carcinoma of the nasal cavity with high-grade histology

Jo, Park; Jung, Chan Kwon; Sun, Dihua; Ms, Kim

doi:10.1017/s0022215111002222

Cited by 22 publications

(28 citation statements)

References 16 publications

(23 reference statements)

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“…Wide surgical excision with a clear margin has been recommended (2)(3)(4)7,10,11). As with other malignant head and neck tumors, EMCa tumors have a propensity for infiltration and local recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…As with other malignant head and neck tumors, EMCa tumors have a propensity for infiltration and local recurrence. Therefore, adjuvant radiotherapy has been recommended, particularly for neoplasms with a diameter of >4 cm, to aid the prevention of local recurrence (4,10,11). The effect of chemotherapy in the treatment of EMCa remains unclear (11,12).…”

Section: Discussionmentioning

confidence: 99%

“…EMCa predominantly arises in the parotid gland, accounting for ~1% of all salivary gland tumors (2)(3)(4). Immunohistochemical studies are useful in the differentiation of EMCa from other similar tumors, highlighting their characteristic biphasic epithelial-myoepithelial phenotype (1).…”

Section: Introductionmentioning

confidence: 99%

“…However, several cases of EMCa have been reported in the mucoserous glands of the upper and lower aerodigestive tract (1,3), including the paranasal sinuses (2), nasopharynx (3), nasal cavity (2), hypopharynx (4), larynx (4), trachea (2,4), bronchus (2) and lungs (5). Additionally, the development of EMCa at unusual sites, for example the breast (2) and lacrimal glands (2,4), has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the development of EMCa at unusual sites, for example the breast (2) and lacrimal glands (2,4), has been reported.…”

Section: Introductionmentioning

confidence: 99%

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Epithelial-myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

et al. 2015

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Abstract. An 80-year-old female with complaints of right-sided nose blockage and occasional epistaxis for several months was referred to Sanggye Paik Hospital (Seoul, Korea). Nasal examination revealed a hemorrhagic mass protruding towards the right posterior nasal cavity, for which the patient was subjected to excisional biopsy. The pathological diagnosis was epithelial-myoepithelial carcinoma, as immunohistochemical analysis revealed that the inner cells stained positive for cytokeratin 7, an epithelial cell marker, whereas the outer cells stained positive for smooth muscle actin and P63, consistent with a myoepithelial phenotype. The patient received concurrent chemoradiation therapy followed by systemic chemotherapy. Following the achievement of a partial response, the patient's treatment course was uneventful. Follow-up at 24 months revealed a stable status at partial response, with no subsequent progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Additionally, the development of EMCa at unusual sites, for example the breast (2) and lacrimal glands (2,4), has been reported.…”

Section: Introductionmentioning

confidence: 99%

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Epithelial-myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

et al. 2015

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Epithelial–Myoepithelial Carcinoma of Nasal Cavity at an Unusual Age: A Case Report and Review of Literature

Mishra

Nanda

Ahirwar

et al. 2023

Indian J Otolaryngol Head Neck Surg

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Myoepithelial Carcinoma of Sinonasal Cavity: Peculiar Diagnosis, Conventional Treatment

Dinker

Rajan

Sharma

et al. 2023

Indian J Otolaryngol Head Neck Surg

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Myoepithelial carcinoma is a morphologically diverse tumor which either arises de novo or from the malignant transformation of its benign counterpart i.e. myoepithelioma. These are relatively lesser known entities and are rarely found in head and neck region. Although rare, their first presentation is usually a painless growing mass as seen in our case presentation as well and are infamous for lymph node recurrence and distant metastasis. Due to their clinical presentation and varied morphology these become tedious to diagnose and pose difficulty for a surgeon when presented at a later date due to their effect on the adjacent vital structures. We report a case of myoepithelial carcinoma in head and neck region arising from the nasal cavity, it’s mass effect on the adjacent vital organs and the diagnosis and treatment plan to render the patient free of this tumor, preservation of the vision and keeping the recurrence of the tumor at bay.

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An unusual presentation of aggressive epithelial-myoepithelial carcinoma of the nasal cavity with high-grade histology

Abstract: We report a rare case of aggressive epithelial-myoepithelial carcinoma in the nasal cavity, with high-grade histology.

Cited by 22 publications

References 16 publications

Epithelial-myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

Epithelial-myoepithelial carcinoma of the nasopharynx: A case report and review of the literature

Epithelial–Myoepithelial Carcinoma of Nasal Cavity at an Unusual Age: A Case Report and Review of Literature

Myoepithelial Carcinoma of Sinonasal Cavity: Peculiar Diagnosis, Conventional Treatment

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