An Unusual Pituitary Mass Revealing a Primary Hypothyroidism!

Moumen, A.; Meftah, A.; Jadi, H. El; Elmoussaoui, S.; Belmejdoub, G.

doi:10.4081/cp.2015.733

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…Increase in Thyrotrophic cells is a phenomenon seen is protracted case of Hypothyroidism and may present with features consistent with pituitary macroadenoma [8]. The mechanism which causes increase In numbers of Thyrotrophic cells is through the negative feedback loop; decrease in levels of circulating thyroid hormones causes the thyrotrophin releasing hormones (TRH) to overstimulate the thyrotrophs [8].…”

Section: Discussionmentioning

confidence: 99%

Pituitary Macroadenoma: A Rare Presentation of Hypothyroidism

Khan¹,

Ram²,

Ali³

et al. 2021

JED

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Hypothyroidism is a common endocrine disease which occurs when the levels of Thyroid hormones produced by the Thyroid gland are decreased. Here we present a case of a 19-year-old female, who presented with symptoms of hyperprolactinemia, weight gain, unilateral blurring of eyes and headache. Examination findings of the patient were significant for presence of Acanthosis Nigricans and Hirsutism. Rest of the systemic examination was normal. Laboratory investigations revealed Hyperprolactinemia, Hypothyroid profile and dyslipidemia. MRI brain and pituitary done showed findings consistent with Pituitary macroadenoma. Patient was treated along the lines of hypothyroidism with Thyroxine. Follow-up after 3 months showed improvement of her symptoms and disappearance of lesion of MRI scan. This case was a rare presentation of Hypothyroidism. Such unusual and uncommon presentations should be reported and studied in detail to prevent misdiagnosis and provide the correct treatment to the patients.

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Section: Discussionmentioning

confidence: 99%

Pituitary Macroadenoma: A Rare Presentation of Hypothyroidism

Khan¹,

Ram²,

Ali³

et al. 2021

JED

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“…Numerous similar clinical cases have also been published, but with reportedly lower prolactin levels (below 100 ng/ml). 14,15 Vitiligo is relatively common (prevalence of 0.5-2.0% of the general population), but its pathogenesis is not fully understood. Autoimmunity as an etiological cause has been suggested because of the frequent association with other autoimmune diseases, with autoimmune thyroid disease present in 14 to 34% of vitiligo cases.…”

Section: Discussionmentioning

confidence: 99%

Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report

Cottas

Borges

Oliveira

et al. 2018

Rev Bras Ginecol Obstet

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Polyglandular autoimmune syndrome type II (PGA-II) is a rare immunoendocrinopathy syndrome characterized by the occurrence of autoimmune Addison disease along with diabetes mellitus type 1 and/or autoimmune thyroid disease. Here, we report the case of a 23-year-old female with PGA-II who was followed up at the dermatology and endocrinology clinics of the Universidade Federal do Triângulo Mineiro, located in the state of Minas Gerais, Brazil. First, the patient presented diffuse skin hyperpigmentation, vitiligo; and in sequence, due to vomiting, appetite and weight loss, hypoglycemia, amenorrhea, and galactorrhea, the patient was then diagnosed with PGA-II. The patient also presented intense hyperprolactinemia due to primary hypothyroidism. The late diagnosis of PGA-II is frequent because the disorder is uncommon and has non-specific clinical manifestations. This report emphasizes the significance of a timely diagnosis and appropriate treatment to reduce morbidity and mortality associated with these diseases, especially Addison disease. The present study reports a rare case of a patient with PGA-II with primary amenorrhea associated with hyperprolactinemia.

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“…Long-standing primary hypothyroidism in children with high serum levels of thyroid-stimulating hormone (TSH), and the subsequent proliferation of TSH-releasing cells, may lead to pituitary hyperplasia, causing what is known as pituitary hyperplasia secondary to primary hypothyroidism (PHPH) [ 1 ]. PHPH was first reported in adults by Niepce in 1851, with similar cases reported thereafter [ 3 – 5 ]. However, PHPH is rarely reported in children; a recent review identified only 18 cases of pediatric PHPH in the literature [ 1 ].…”

Section: Introductionmentioning

confidence: 92%

Primary Hypothyroidism with Pituitary Hyperplasia in an Omani Girl

Fadle

Reesi

Al-Shabibi

et al. 2022

Case Reports in Endocrinology

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Pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is uncommon in children and is reversible with thyroxine therapy. We report an Omani girl who presented at the age of 13 years and 6 months with profound primary hypothyroidism due to Hashimoto’s thyroiditis and secondary pituitary hyperplasia and hyperprolactinemia. Pituitary magnetic resonance imaging confirmed the presence of pituitary hyperplasia which regressed during follow-up after the administration of thyroxine therapy. The diagnosis of PHPH is very important in both children and adults in order to avoid unnecessary brain surgery or medical treatment for a presumed pituitary mass or adenoma. To our knowledge, this patient represents the first case of an Omani child presenting with PHPH.

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An Unusual Pituitary Mass Revealing a Primary Hypothyroidism!

Cited by 8 publications

References 9 publications

Pituitary Macroadenoma: A Rare Presentation of Hypothyroidism

Pituitary Macroadenoma: A Rare Presentation of Hypothyroidism

Primary Amenorrhea Associated with Hyperprolactinemia in Polyglandular Autoimmune Syndrome Type II: A Case Report

Primary Hypothyroidism with Pituitary Hyperplasia in an Omani Girl

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