Primary Hypothyroidism with Pituitary Hyperplasia in an Omani Girl

Abstract

Pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is uncommon in children and is reversible with thyroxine therapy. We report an Omani girl who presented at the age of 13 years and 6 months with profound primary hypothyroidism due to Hashimoto’s thyroiditis and secondary pituitary hyperplasia and hyperprolactinemia. Pituitary magnetic resonance imaging confirmed the presence of pituitary hyperplasia which regressed during follow-up after the administration of thyroxine therapy. The diagnosis of PHPH is very important in both children and adults in order to avoid unnecessary brain surgery or medical treatment for a presumed pituitary mass or adenoma. To our knowledge, this patient represents the first case of an Omani child presenting with PHPH.

Thyroxine Therapy Treating Infertility and Pituitary Tumor: Primary Hypothyroidism Leading to Pituitary Hyperplasia

“…Patients treated with thyroxine having pituitary hyperplasia and hypothyroidism need interval monitoring with an MRI scan to ascertain the change in the pituitary lesion. If there is no reduction in size with thyroxine treatment, the diagnosis needs to be reconsidered [ 10 ]. Our patient had improvement in her symptoms within a couple of weeks after she was started on thyroxine therapy.…”